Abstract：
PURPOSE:To examine whether the survival benefit of exercise is modified by obesity. METHODS:In the Northern Manhattan Study, we collected baseline sociodemographics and cardiovascular disease risk factors. The primary exposure was leisure-time physical activity (LTPA) and the outcomes were total, vascular, and nonvascular deaths (non-VaD). LTPA was defined as any versus none and metabolic equivalent score category (total activity weighted by intensity). We used Cox models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS:A total of 3298 participants (mean age 69 years, 52% Hispanic, 63% women) were followed over a mean of 11.8 years with 1589 total deaths (641 vascular, 819 nonvascular). Any activity (adjusted HR: 0.84, 95% CI: 0.75-0.94) was associated with reduced risk of all-cause mortality and non-VaD, but not VaD. We found an interaction (P < .05) of LTPA with body mass index (BMI) less than 30 for all-cause and vascular mortality. Any LTPA was associated with reduced all-cause mortality (adjusted HR: 0.77, 95% CI: 0.68-0.87) and VaD (adjusted HR: 0.79, 95% CI: 0.65-0.97) only among those with BMI less than 30. CONCLUSIONS:We found no evidence of an independent survival benefit of LTPA among those with BMI more than 30. The health benefits of exercise should be considered in the context of obesity.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Willey JZ,Moon YP,Sherzai A,Cheung YK,Sacco RL,Elkind MSdoi
10.1016/j.annepidem.2015.04.001subject
Has Abstractpub_date
2015-07-01 00:00:00pages
475-479.e2issue
7eissn
1047-2797issn
1873-2585pii
S1047-2797(15)00135-0journal_volume
25pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-07-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章,多中心研究
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更新日期：2001-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：Annals of epidemiology
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更新日期：2015-08-01 00:00:00
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更新日期：2008-04-01 00:00:00
