National and sub-national trend of prevalence and burden of dementia in Iran, from 1990 to 2013; study protocol.


BACKGROUND:Dementia is a disabling syndrome, which generally affects aged population more than any other age groups. This syndrome has a growing prevalence and incidence worldwide. The prevalence and burden of this group of diseases in Iran have not been estimated in a community-based study yet. This paper aims to explain the systematic approach, data sources, research methodology, and statistical analysis that will be used to quantify the prevalence and burden of dementia at national and sub-national levels. METHODS:This is the protocol of a secondary data study that explains the design and method of conducting the study. We will use several sources of data that will include a systematic review of articles and gray literature which have reported the prevalence or incidence of dementia and its uncertainty at national and sub-national levels in Iran, in addition to data about dementia-specific drug sales per each year at provincial levels, as well as data extracted from 23 million health insurance prescriptions over 8 years and some data from medical documents of Iranian Alzheimer's Association members. The technical groups of National and Sub-national Burden of Disease will collect some covariate data, such as age and sex structure of population, urbanization status, mean years of schooling, plasma cholesterol, fasting plasma glucose, and systolic and diastolic blood pressure at provincial levels which will be used in our models. Two statistical models, namely spatio-temporal and hierarchical autoregressive models, will be used for interpolation and extrapolation of missing data. CONCLUSION:It seems that the study of national and sub-national burden of dementia could provide more accurate estimation of prevalence and burden of dementia in Iran with an acceptable level of uncertainty than the previous studies.


Arch Iran Med


Sharifi F,Najafi B,Fakhrzadeh H,Noroozian M,Naderimagham S,Philp I,Arzaghi SM,Alizadeh M,Shoaee S,Hassannia T,Sheidaei A,Moradi-Lakeh M,Farzadfar F,Larijani B




Has Abstract


2014-12-01 00:00:00














  • PolyPill for Prevention of Cardiovascular Disease in an Urban Iranian Population with Special Focus on Nonalcoholic Steatohepatitis: A Pragmatic Randomized Controlled Trial within a Cohort (PolyIran - Liver) - Study Protocol.

    abstract:BACKGROUND:Cardiovascular disease (CVD) is among the most common causes of mortality in all populations. Nonalcoholic steatohepatitis is a common finding in patients with CVD. Prevention of CVD in individual patients typically requires periodic clinical evaluation, as well as diagnosis and management of risk factors su...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Merat S,Poustchi H,Hemming K,Jafari E,Radmard AR,Nateghi A,Shiravi Khuzani A,Khoshnia M,Marshall T,Malekzadeh R

    更新日期:2015-08-01 00:00:00

  • Knowledge, attitude, and practice of adults to the protective actions against sun in northwest Tehran, Iran.

    abstract:BACKGROUND:Wrong beliefs about risky actions such as sunbathing and tanning are common due to media advertisements or general lack of knowledge. This work has focused on the knowledge and attitude of a group of citizens in Tehran, Iran and the protective actions they take regarding undesirable effects of the sun.    M...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Mousavi F,Golestan B,Vaseie M,Vaseie L,Khajeh-Kazemi R

    更新日期:2011-03-01 00:00:00

  • The neurological outcome of spinal cord injured victims of the Bam earthquake, Kerman, Iran.

    abstract::Car accidents and gun-shot injuries are the most common causes of spinal cord injury. Five percent of those patients who have a complete spinal cord injury will experience improvement, to some extent. The lack of specific data in the literature regarding the outcome of earthquake related spinal cord injury justified u...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Karamouzian S,Saeed A,Ashraf-Ganjouei K,Ebrahiminejad A,Dehghani MR,Asadi AR

    更新日期:2010-07-01 00:00:00

  • Surgical intervention for treatment of septic arthritis in infancy and childhood; a retrospective study.

    abstract::Septic arthritis is a fearful condition because of its mortality and the potentially late sequels on immature skeleton including limb shortening, osteomyelitis, destruction of joint surface, severe limitation of motion, and dislocation.This study was performed to reveal the final outcome of our patients and find out t...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Kariminasab MH,Shayesteh Azar M,Sajjadi Saravi M

    更新日期:2009-07-01 00:00:00

  • Six-year follow up of imatinib therapy for newly diagnosed chronic myeloid leukemia in Iranian patients.

    abstract:BACKGROUND:The present study reported a six-year follow up of patients with chronic myeloid leukemia who were on imatinib therapy. METHODS:We performed a retrospective study on a total of 417 patients diagnosed with chronic-phase, Philadelphia-positive (Ph+) chronic myeloid leukemia within six months before study entr...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Jalaeikhoo H,Ahmadzadeh A,Toogeh G,Haybar H,Valizadeh A,Charoosaei R,Yadollahzadeh M,Keyhani M

    更新日期:2011-11-01 00:00:00

  • Iron Oxide Nanoparticles Reduced Retinoic Acid Induced-neuronal Differentiation of Mouse Embryonic Stem Cells By ROS Generation.

    abstract:BACKGROUND:In recent years the increasing use of nanoparticles has led researchers to study their effects on biological systems. The most important effects of nanoparticles on cells are their ability to induce or suppress production of reactive oxygen species (ROS). Changes in reactive oxygen species play an important ...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Rostami AA,Mohseni Kouchesfahani H,Kiani S,Fakheri R

    更新日期:2015-09-01 00:00:00

  • Mushroom Extracts Induce Human Colon Cancer Cell (COLO-205) Death by Triggering the Mitochondrial Apoptosis Pathway and Go/G1-Phase Cell Cycle Arrest.

    abstract:BACKGROUND:Functional foods are extensively studied for their cancer preventive effects. In the present study, we compared the anti-cancer activity of aqueous extracts of three species of mushrooms including: Pleurotus ostreatus (PAE), Auricularia polytricha (AAE) and Macrolepiota procera (MAE) on COLO-205 cells. METH...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Arora S,Tandon S

    更新日期:2015-05-01 00:00:00

  • Child and Adolescent Mental Health Care in Iran: Current Status and Future Directions.

    abstract:BACKGROUND:The need for mental health care among children and adolescents in Iran, as in other low and middle income countries (LAMIC) remains mostly unmet. In this paper, we sought to provide an overview of the extent of unmet need and mental health services in Iran. We also aimed to propose approaches to address this...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Sharifi V,Mojtabai R,Shahrivar Z,Alaghband-Rad J,Zarafshan H,Wissow L

    更新日期:2016-11-01 00:00:00

  • Monte Carlo Determination of Dosimetric Parameters of a New (125)I Brachytherapy Source According to AAPM TG-43 (U1) Protocol.

    abstract:BACKGROUND:(125)I is one of the important sources frequently used in brachytherapy. Up to now, several different commercial models of this source type have been introduced to the clinical radiation oncology applications. Recently, a new source model, IrSeed-125, has been added to this list. The aim of the present study...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Baghani HR,Lohrabian V,Aghamiri MR,Robatjazi M

    更新日期:2016-03-01 00:00:00

  • Endoscopic endonasal surgery for resection of benign sinonasal tumors: experience with 105 patients.

    abstract:BACKGROUND:The use of endoscopic surgery for nasal and sinus pathologies has revolutionized our approaches towards the diseases of these areas. OBJECTIVE:To report our experience with endoscopic surgery of benign tumors and tumor-like conditions of the nose and paranasal sinuses. METHODS:The medical records of 105 pa...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Baradaranfar MH,Dabirmoghaddam P

    更新日期:2006-07-01 00:00:00

  • Practical strategies to reduce morbidity and mortality of natural catastrophes: a retrospective study based on Bam earthquake experience.

    abstract:BACKGROUND:Critical analysis of shortcomings of emergency medical management of earthquake casualties will provide an invaluable insight to improve outcomes for future events. Using a critical analysis methodology to evaluate the quality of emergency medical management after Bam earthquake, we suggest a practical strat...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Najafi I,Safari S,Sharifi A,Sanadgol H,Hosseini M,Rashid-Farokhi F,Seirafian S,Mooraki A,Samimagham H,Osare S,Pourfarziani V,Atabak S,Boroumand B

    更新日期:2009-07-01 00:00:00

  • Functional Analysis of RELN S2486G Mutation and its Contribution to Pathogenesis of Ankylosing Spondylitis.

    abstract:BACKGROUND:Ankylosing spondylitis (AS; OMIM:106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the RELN gene (OMIM: 600514) which was associated with AS. This study is designed to investigate the potential effect of RELN S2486G mutation on reelin secretion; addition...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Esmaeilzadeh-Gharehdaghi E,Razmara E,Bitaraf A,Jamshidi A,Mahmoudi M,Garshasbi M

    更新日期:2020-10-01 00:00:00

  • Traumatic ulcerative granuloma with stromal eosinophilia.

    abstract::Chronic ulcers of the oral mucosa are the lesions which a physician comes across frequently. "Eosinophilic Ulcer" is a rare variety of that. Eosinophilic ulcer or traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a chronic benign lesion of the oral mucosa and is a relatively recent delineated entity....

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Chandra S,Raju S,Sah K,Anand P

    更新日期:2014-01-01 00:00:00

  • Medical management of diabetic retinopathy: an overview.

    abstract::Diabetes mellitus is a global health problem affecting 366 million people worldwide and its prevalence is growing rapidly. Diabetic eye disease is present in up to 25% of diabetic subjects. Diabetic retinopathy is a chronic complication of diabetes that can result in blindness. Generally, there are two stages of diabe...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章,评审


    authors: Malek M,Khamseh ME,Aghili R,Emami Z,Najafi L,Baradaran HR

    更新日期:2012-10-01 00:00:00

  • Prognostic values of proliferative markers ki-67 and repp86 in breast cancer.

    abstract:BACKGROUND:Breast cancer is the leading cause of carcinoma death in women. Proper treatment depends on the consideration of molecular biology status of tumor cells, which may determine the patient's treatment and prognosis. To determine the prognostic models for this disease, we evaluated the role of cell proliferation...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章,多中心研究


    authors: Mohsenifar J,Almassi-Aghdam M,Mohammad-Taheri Z,Zare K,Jafari B,Atri M,Mortazavi SH,Azadeh P,Bagherzadeh M,Azargashb E,Rahimi F

    更新日期:2007-01-01 00:00:00

  • Genotype analysis of hepatitis delta virus from hepatitis B surface antigen-positive patients using PCR-RFLP in Tehran, Iran.

    abstract:BACKGROUND:Hepatitis delta virus is a unique human pathogen responsible for some 20 million infections globally. This virus is dependent on hepatitis B virus for transmission and propagation. Currently, at least three genotypes of hepatitis delta virus with different geographic distribution and clinical manifestations ...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Mirshafiee H,Mahmoodian-Shooshtari M,Sharifi Z,Hosseini SM

    更新日期:2009-05-01 00:00:00

  • Environmental and lifestyle risk factors of gastric cancer.

    abstract::Effective prevention and early diagnostic strategies are the most important public health interventions in gastric cancer, which remains a common malignancy worldwide. Preventive strategies require identification and understanding of environmental risk factors that lead to carcinogenesis. Helicobacter pylori (H. pylor...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章,评审


    authors: Lee YY,Derakhshan MH

    更新日期:2013-06-01 00:00:00

  • Evaluation of current guthrie TSH cut-off point in Iran congenital hypothyroidism screening program: a cost-effectiveness analysis.

    abstract:BACKGROUND:The threshold of thyroid-stimulating hormone (TSH) in current screening for congenital hypothyroidism (CH) from the heel prick test is 5 mU/l. This study uses cost-effective analysis to evaluate increasing the threshold to minimize false-positive results and recall rates. METHODS:Cost of screening, diagnosi...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Shamshiri AR,Yarahmadi S,Forouzanfar MH,Haghdoost AA,Hamzehloo G,Holakouie Naieni K

    更新日期:2012-03-01 00:00:00

  • Phase 1 trial of autologous bone marrow mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis.

    abstract:BACKGROUND:The standard treatment for decompensated liver cirrhosis is liver transplantation. However, it has several limitations. Recent animal studies suggest that bone marrow stem cell transplantation can lead to regression of liver fibrosis. The objective of this study was to determine the safety and feasibility of...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Mohamadnejad M,Alimoghaddam K,Mohyeddin-Bonab M,Bagheri M,Bashtar M,Ghanaati H,Baharvand H,Ghavamzadeh A,Malekzadeh R

    更新日期:2007-10-01 00:00:00

  • Multiple Gastritis Cystica Profunda in a Patient without Gastric Surgery History.

    abstract::Gastritis cystica profunda (GCP) is a rare condition characterized by polypoid cystic ectasia of the submucosal layer with cystic dilatation of the glandular structures of the stomach. The probable pathogenesis refers to degradation of the integrity of the muscularis mucosa and migration of epithelial cells to the sub...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Dikicier E,Altintoprak F

    更新日期:2018-12-01 00:00:00

  • Five-Year Efficacy of Transobturator Tape Treatment and Quality of Life in Women with Stress Urinary Incontinence.

    abstract:BACKGROUND:We aimed to assess the results of first- and fifth-year outcomes and the effect on quality of life (QoL) of transobturator tape (TOT) treatment in patients with stress urinary incontinence (SUI). METHODS:The patients who underwent TOT surgery between January 2008 and June 2013 were screened retrospectively....

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Sahin MO,Sen V,Irer B,Yildiz G

    更新日期:2020-12-01 00:00:00

  • Prevalence of Cognitive Disorders in Patients with Systemic Lupus Erythromatosus; a Cross-sectional Study in Rasoul-e-Akram Hospital, Tehran, Iran.

    abstract:BACKGROUND:Neuropsychological manifestations are present in 60% of patients with Systemic Lupus Erythematosus (SLE) among which cognitive dysfunction is the most common. This study aims to determine the prevalence of cognitive disorders in SLE patients, and the relationship between cognitive disorder domains and depres...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Mahdavi Adeli A,Haghighi A,Malakouti SK

    更新日期:2016-04-01 00:00:00

  • Correlation of P53 and granzyme B expression in oral squamous cell carcinoma with clinicopathologic findings.

    abstract:BACKGROUND:The present study aimed to evaluate the correlation of P53 and granzyme B (GB) expression, and also the relationship between P53 expression and GB+ cell density with lymph node metastasis, histologic grade, and inflammation intensity in oral squamous cell carcinoma (OSCC).  METHODS:Immunohistochemical techn...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Taghavi N,Khaleghjou A,Mahdavi N

    更新日期:2013-09-01 00:00:00

  • Impact of Age at Menarche on Breast Cancer: The Assessment of Recall Bias.

    abstract:BACKGROUND:Our aim was to determine the association between age at menarche (AAM) and breast cancer adjusted for recall bias (misclassification) in AAM. METHODS:We have used data provided from a case-control study conducted in Iran from 2005 to 2009. The cases and controls were frequency matched based on 5-year age gr...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Moradzadeh R,Mansournia MA,Ghiasvand R,Baghfalaki T,Nadrian H,Holakouie-Naieni K

    更新日期:2019-02-01 00:00:00

  • WHO Ending Childhood Obesity and Iran-Ending Childhood Obesity Programs Based on Urban Health Equity Indicators: A Qualitative Content Analysis.

    abstract:BACKGROUND:The childhood obesity epidemic is one of the most serious global health challenges, and many relevant policies have been designed and implemented. Regarding health equity policy-making, it is important to adopt proper interventional strategies, including childhood obesity policies. The purpose of this study ...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Ezzeddin N,Eini-Zinab H,Ajami M,Kalantari N,Sheikhi M

    更新日期:2019-11-01 00:00:00

  • A case-control study on potato consumption and risk of stroke in central Iran.

    abstract:UNLABELLED:  BACKGROUND:Potato, a high- glycemic index (GI) food, is one of the most widely used starchy foods worldwide. Previous studies on the association of dietary intakes with stroke have mostly focused on the dietary GI and there is no information regarding the association between potato consumption and risk of...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Khosravi-Boroujeni H,Saadatnia M,Shakeri F,Keshteli AH,Esmaillzadeh A

    更新日期:2013-03-01 00:00:00

  • Family physician program in Iran: considerations for adapting the policy in urban settings.

    abstract::Nationwide implementation of Family Physician (FP) program started in 2005 and targeted almost 25,000,000 citizens residing in rural areas and cities with less than 20,000 populations in Iran. Despite its blatant initiation that resulted in some modest achievements, the future of FP looks unclear in Iran. Thus far, no...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Khayatzadeh-Mahani A,Takian A

    更新日期:2014-11-01 00:00:00

  • Socioeconomic Disparities in Dietary and Physical Activity Habits of Iranian Children and Adolescents: the CASPIAN-IV Study.

    abstract:BACKGROUND:This study aims to compare the dietary and physical activity (PA) habits in a nationally representative sample of Iranian children and adolescents based on their family and regional socioeconomic status (SES). METHOD:This nationwide study was conducted on 14,880 students, aged 6-18 years, and one of their p...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Kelishadi R,Qorbani M,Motlagh ME,Ardalan G,Heshmat R,Hovsepian S

    更新日期:2016-08-01 00:00:00

  • Regulation of adipokines by polyunsaturated fatty acids in a rat model of non-alcoholic steatohepatitis.

    abstract:BACKGROUND:Recent evidence has indicated that polyunsaturated fatty acids (PUFA), such as omega-3 PUFA, have protective effects on a range of chronic inflammatory conditions, including obesity, and may play a role in the reversal of steatohepatitis. However, the effects of omega-3 PUFA on adipokine expression and hepat...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Ding WJ,Wang Y,Fan JG

    更新日期:2014-08-01 00:00:00

  • The short- and long- term effects of estrogen deficiency on apoptosis in musculoskeletal tissues: an experimental animal model study.

    abstract:BACKGROUND:Estrogen is the major sex steroid affecting the growth, remodeling, and homeostasis of the female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, muscles, and menisci in ovariecto...

    journal_title:Archives of Iranian medicine

    pub_type: 杂志文章


    authors: Aydin A,Kenar H,Atmaca H,Alici T,Gacar G,Müezzinoğlu ÜS,Karaöz E

    更新日期:2013-05-01 00:00:00