Abstract：
BACKGROUND:The standard treatment for decompensated liver cirrhosis is liver transplantation. However, it has several limitations. Recent animal studies suggest that bone marrow stem cell transplantation can lead to regression of liver fibrosis. The objective of this study was to determine the safety and feasibility of autologous bone marrow-mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis. METHODS:In this phase 1 trial, four patients with decompensated liver cirrhosis were included. Their bone marrow was aspirated, mesenchymal stem cells were cultured, and a mean 31.73 x 10(6) mesenchymal stem cells were infused through a peripheral vein. Primary outcomes were evaluating the safety and feasibility of the work. Secondary outcomes were evaluating changes in the model for end-stage liver disease score, and the quality of life of the patients. RESULTS:There were no side-effects in the patients during follow-up. The model for end-stage liver disease scores of patients 1, and 4 improved by four and three points, respectively by the end of follow-up. Furthermore, the quality of life of all four patients improved by the end of follow-up. Using SF-36 questionnaire, the mean physical component scale increased from 31.44 to 65.19, and the mean mental component scale increased from 36.32 to 65.55. CONCLUSION:Mesenchymal stem cell transplantation seems to be feasible and safe in the treatment of decompensated liver cirrhosis.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Mohamadnejad M,Alimoghaddam K,Mohyeddin-Bonab M,Bagheri M,Bashtar M,Ghanaati H,Baharvand H,Ghavamzadeh A,Malekzadeh Rdoi
07104/AIM.008subject
Has Abstractpub_date
2007-10-01 00:00:00pages
459-66issue
4eissn
1029-2977issn
1735-3947pii
008journal_volume
10pub_type
杂志文章abstract：BACKGROUND:The threshold of thyroid-stimulating hormone (TSH) in current screening for congenital hypothyroidism (CH) from the heel prick test is 5 mU/l. This study uses cost-effective analysis to evaluate increasing the threshold to minimize false-positive results and recall rates. METHODS:Cost of screening, diagnosi...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：012153/AIM.006
更新日期：2012-03-01 00:00:00
abstract：:This article discusses the importance, definition, and types of confounders in epidemiology. Methods to identify and address confounding are discussed, as well as their strengths and limitations. The article also describes the difference among confounders, mediators, and effect modifiers. ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：012158/AIM.0014
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:The current WHO classification of hematologic malignancies defines distinct entities of myeloid disorders based on the presence of recurrent cytogenetic abnormalities. Diagnostic clonal chromosomal abnormalities provide important prognostic information and are among the most important factors in predicting i...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013168/AIM.005
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Recent advances in pharmacy practice have created serious ethical challenges for the pharmacists. Pursuing a new philosophy of practice is required to overcome these challenges and optimize the standard of care. In this regard, the current ethics guideline in the Pharmacy curriculum used in Tehran Universi...
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doi：0172001/AIM.009
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:This research aims to determine the mental health status of population aged 15 and over in the province of Razavi Khorasan in 2015. METHODS:The statistical population of this cross-sectional field survey consisted of residents of urban and rural areas of Razavi Khorasan in Iran. An estimated sample size o...
journal_title：Archives of Iranian medicine
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abstract：BACKGROUND:Co-occurring methamphetamine (METH) use during methadone maintenance therapy (MMT) is a highly prevalent and progressive problem in Iran. There are no registered pharmacological treatments for treating METH use disorder. The present study investigates the potential efficacy of atomoxetine in the treatment of...
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pub_type： 杂志文章,随机对照试验
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更新日期：2014-12-01 00:00:00
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journal_title：Archives of Iranian medicine
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更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2017-06-01 00:00:00
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doi：
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pub_type： 传,历史文章,杂志文章
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更新日期：2015-06-01 00:00:00
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更新日期：2014-06-01 00:00:00
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更新日期：2011-05-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
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更新日期：2008-05-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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更新日期：2008-01-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 历史文章,杂志文章
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2008-03-01 00:00:00
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更新日期：2014-10-01 00:00:00
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更新日期：2013-09-01 00:00:00
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doi：
更新日期：2009-05-01 00:00:00
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更新日期：2007-10-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章,收录出版
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更新日期：2008-05-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
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更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
