Abstract:
BACKGROUND:Functional foods are extensively studied for their cancer preventive effects. In the present study, we compared the anti-cancer activity of aqueous extracts of three species of mushrooms including: Pleurotus ostreatus (PAE), Auricularia polytricha (AAE) and Macrolepiota procera (MAE) on COLO-205 cells. METHODS:Various in vitro approaches were performed to investigate the most potential mushroom variety that possesses maximum cytotoxic, anti-proliferative and apoptosis inducing properties. MTT assay was used to assess cytotoxicity. IC50 values were obtained and further used to perform clonogenic survival, wound scratch and apoptosis assays. Gene expression studies of apoptosis and cell cycle related studies were performed by reverse transcriptase PCR, followed by estimation of DNA content by flow cytometric analysis. RESULTS:Our study showed that PAE acts as the most prominent inducer of cancer cell death as compared to other species. Therefore, we performed expression studies for apoptosis and cell cycle to understand the genes which are responsible for their profound activities. Expression studies illustrated increased levels of caspase-9 (1 to 2.1, P < 0.01), caspase-3 (1 to 1.7, P < 0.01) and Bax (1 to 1.4, P < 0.05) genes followed by decreased levels of Bcl-2 (1 to 0.44, P < 0.05) gene with PAE treatment and this was attributed to the activation of intrinsic pathway. Along with apoptosis, an arrest at Go/G1 phase was observed through flow cytometric analysis followed by increased expression of inhibitors of cyclin dependent kinases (CKIs), p16 (1 to 1.5, P < 0.05) and p21 (1 to 2.4, P < 0.01). CONCLUSION:This study exemplifies the effectiveness of PAE and may serve as a potential therapeutic agent.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Arora S,Tandon Sdoi
0151805/AIM.006subject
Has Abstractpub_date
2015-05-01 00:00:00pages
284-95issue
5eissn
1029-2977issn
1735-3947pii
006journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Genetic and expression anomaly of HER-2 have been frequently observed in different cancers. However, an overall association of HER-2 polymorphism (Ile655Val) with available cancer studies has not yet been explored. In the present study, a probable correlation of HER-2 Ile655Val polymorphism with 6 major type...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,meta分析,评审
doi:0161906/AIM.0011
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Estimation of health workforce supply becomes problematic when there is no knowledge about the number of active specialists. The aim of this study is to estimate active specialists and their geographic accessibility in Iran. METHODS:We enrolled all medical specialists from the Iranian Ministry of Health dat...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Previous studies reported the association between dietary patterns and prevalence of diabetes, cardiovascular disease and other chronic disease. However, there are no studies reporting major dietary patterns in patients awaiting coronary artery bypass graft surgery (CABG). The aim of this study was to obtain...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161907/AIM.005
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The Fas/Fas ligand (FasL) system has been recognized as an important pathway for apoptosis induction in cells and tissues. It has recently been shown that skin lesions of pemphigus vulgaris are associated with Fas mediated apoptosis. The aim of this study was to evaluate the level of serum soluble Fas of ten...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:011143/AIM.0011
更新日期:2011-05-01 00:00:00
abstract::Systemic therapy is one of the cornerstones of cancer treatment. In 1972, following representations by American Society of Clinical Oncology (ASCO), the American Board of Internal Medicine (ABIM) recognized medical oncology as a new subspecialty of internal medicine. Subspecialty of Hematology and Medical Oncology was...
journal_title:Archives of Iranian medicine
pub_type: 历史文章,杂志文章
doi:0151811/AIM.0013
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:During the last 3 decades, Iran has experienced a rapid population growth and at the same time the health of Iranian people has improved greatly. This achievement was mainly due to training and availability of health manpower, well organized public health network and medical science and research improvement....
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The present study was conducted to determine the health-related quality of life in patients living with human immunodeficiency virus or suffering from acquired immune deficiency syndrome (HIV/AIDS), referred to Behavioral Diseases Consultation Center in west of Tehran, Iran. METHODS:This cross-sectional stu...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Co-occurring methamphetamine (METH) use during methadone maintenance therapy (MMT) is a highly prevalent and progressive problem in Iran. There are no registered pharmacological treatments for treating METH use disorder. The present study investigates the potential efficacy of atomoxetine in the treatment of...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease (CVD) is among the most common causes of mortality in all populations. Nonalcoholic steatohepatitis is a common finding in patients with CVD. Prevention of CVD in individual patients typically requires periodic clinical evaluation, as well as diagnosis and management of risk factors su...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:015188/AIM.009
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:It is known that there is an association between elevated total plasma homocysteine level and restenosis after percutaneous coronary angioplasty. OBJECTIVE:To evaluate the effect of lowering plasma homocysteine levels on the rate of restenosis after stent-percutaneous coronary angioplasty. METHODS:Folic ac...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:This study aims to compare the dietary and physical activity (PA) habits in a nationally representative sample of Iranian children and adolescents based on their family and regional socioeconomic status (SES). METHOD:This nationwide study was conducted on 14,880 students, aged 6-18 years, and one of their p...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161908/AIM.003
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Estrogen is the major sex steroid affecting the growth, remodeling, and homeostasis of the female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, muscles, and menisci in ovariecto...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013165/AIM.006
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Neuropsychological manifestations are present in 60% of patients with Systemic Lupus Erythematosus (SLE) among which cognitive dysfunction is the most common. This study aims to determine the prevalence of cognitive disorders in SLE patients, and the relationship between cognitive disorder domains and depres...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161904/AIM.006
更新日期:2016-04-01 00:00:00
abstract::Squamous cell carcinoma of the tongue is uncommon among children and teenagers. Most commonly, squamous cell carcinoma of the head and neck presents during the fifth and sixth decades of life in patients with a long history of tobacco and alcohol use. The rarity of this lesion in young patients implies that clinicians...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,收录出版
doi:08113/AIM.0020
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Physical inactivity is one of the leading causes of major chronic disease, which contributes substantially to the global burden of disease, death and disability. This study examined physical activity in a randomly selected sample of elderly people in Tehran, Iran. METHODS:A random sample of 400 elderly peop...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:010136/0014
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:we aimed to recap and highlight the major results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 by mortality and morbidity to clarify the current health priorities and challenges in Iran. METHODS:We estimated Iran's mortality and burden of 289 diseases with 67 risk factors and 1160...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141705/AIM.004
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Platelet concentrates (PC) are used in thrombocytopenia and inherited or acquired platelet dysfunction disorders. Thus, retaining the platelets quality and function during storage will lead to desirable outcomes in treatment of such patients. METHODS: In this study, we evaluated 40 PC bags, ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:015182/AIM.0010
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:There is a lack of data regarding the incidence rate, etiology, risk factors, and natural course of thyroid disorders and their relationship with cardiovascular disease and mortality in populations undergoing nutrition transition. Therefore, we aimed to assess the natural course of thyroid disease in Tehrani...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013167/AIM.0011
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Critical analysis of shortcomings of emergency medical management of earthquake casualties will provide an invaluable insight to improve outcomes for future events. Using a critical analysis methodology to evaluate the quality of emergency medical management after Bam earthquake, we suggest a practical strat...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::On January 23, 2020, the Chinese government announced the city lockdown of Wuhan. Since then, there have been controversial debates among experts about the efficacy of mass quarantine, the oldest and probably one of the most effective methods for controlling infectious disease outbreaks. The impact of health policymak...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:10.34172/aim.2020.08
更新日期:2020-04-01 00:00:00
abstract::As there is a significant number of Iranian immigrant and illegal refugees living in marginal areas of large cities that might induce immunization gap in these areas. The aim of this study was to provide reliable information on vaccination status of these people. A cross sectional study was conducted on children 24-4...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141710/AIM.0011
更新日期:2014-10-01 00:00:00
abstract::Septic arthritis is a fearful condition because of its mortality and the potentially late sequels on immature skeleton including limb shortening, osteomyelitis, destruction of joint surface, severe limitation of motion, and dislocation.This study was performed to reveal the final outcome of our patients and find out t...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::Infection-associated hemophagocytic syndrome is a life-threatening condition characterized by prolonged fever, hepatosplenomegaly, and cytopenia-most commonly, thrombocytopenia and anemia. It is characterized by proliferation and activation of benign histiocytes, causing dysfunction of various organs. Herein, we repor...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Non-invasive ventilation (NIV) has brought about a significant change in care and treatment of respiratory distress syndrome (RDS) in very low birth weight (VLBW) neonates. The present study was designed and conducted to evaluate different strategies of initial respiratory support (IRS) in VLBW neonates hosp...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0172003/AIM.008
更新日期:2017-03-01 00:00:00
abstract::Diabetes mellitus is a global health problem affecting 366 million people worldwide and its prevalence is growing rapidly. Diabetic eye disease is present in up to 25% of diabetic subjects. Diabetic retinopathy is a chronic complication of diabetes that can result in blindness. Generally, there are two stages of diabe...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:0121510/AIM.0011
更新日期:2012-10-01 00:00:00
abstract::The primary goal of therapy in patients with chronic hepatitis B is suppression and long-lasting maintenance of hepatitis B virus DNA to its lowest possible level. The threshold of hepatitis B virus DNA level for therapy is > or = 10(5) copies/mL for HBeAg-positive patients and > or = 10(4) for those with HBeAg-negati...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract::Following the Islamic Revolution of 1979 in Iran, the trend of migration of physicians from the country continued. The total number of Iranian physicians migrated to the United States (US) increased from 1625 before revolution in 1974, to 5045 in 2010, thirty years post-revolution. The percentage of medical graduates ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0131610/AIM.008
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori isolates from 84 adults and 51 children were assessed during the period of 2001 through 2004 to find out whether their susceptibilities to metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone differ between the two groups or have changed compared with the results fro...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a major health problem in many developing countries including Iran. ESCC has a very poor prognosis, largely due to late diagnosis. As a first step in developing an early detection and treatment program, we conducted a population-based endoscopic screening for ESCC...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:014174/AIM.006
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:Studies on gastric mucosal histological findings among first degree relatives (FDR) of gastric cancer (GC) patients are scarce. The aim is to evaluate the topography and the severity of gastritis among FDR of GC patients. DESIGN:A total of 989 subjects who were FDR of GC patients, ages 40-65 years underwent...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:010136/AIM.004
更新日期:2010-11-01 00:00:00