Abstract：
:The primary goal of therapy in patients with chronic hepatitis B is suppression and long-lasting maintenance of hepatitis B virus DNA to its lowest possible level. The threshold of hepatitis B virus DNA level for therapy is > or = 10(5) copies/mL for HBeAg-positive patients and > or = 10(4) for those with HBeAg-negative chronic hepatitis B. Interferon alpha-2b, lamivudine, and adefovir-dipivoxil are approved by FDA and could all be used as an initial first-line therapy in chronic hepatitis B. Adding lamivudine to either conventional interferon or peg-interferon did not increase the efficacy. Adding lamivudine to adefovir had also no additional effect in compensated patients. Response rate is about 30% - 40% with first-line drugs. Peg-interferon, which recently received the FDA approval, is associated with an increased response rate. Further long-term studies are required to use peg-interferon as a widespread first-line treatment. Treatment strategy is changing towards using prolonged combination therapy with evolving nucleoside analogues with or without an immunomodulatory agent, aiming at eradicating covalently closed circular DNA.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Montazeri Gsubject
Has Abstractpub_date
2006-01-01 00:00:00pages
1-10issue
1eissn
1029-2977issn
1735-3947journal_volume
9pub_type
杂志文章,评审abstract：:The history of early attempts of blood transfusion in Iran traces back to the 1940s; however, around three decades later in 1974, the Iranian National Blood Transfusion Service (Sazeman-e Melli-e Enteqal-e Khun-e Iran) was founded by the outstanding hematologist, Professor Fereydoun Ala. The main goals of this central...
journal_title：Archives of Iranian medicine
pub_type： 传,历史文章,杂志文章
doi：015186/AIM.0016
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Estrogen is the major sex steroid affecting the growth, remodeling, and homeostasis of the female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, muscles, and menisci in ovariecto...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013165/AIM.006
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:In the present study, the effect of dextromethorphan on antinociception and tolerance induced by water swim-stress in the formalin test was investigated. METHODS:Swim-stress at 8 masculineC induces antinociception in both phases of the formalin test. Intraperitoneal administration of dextromethorphan (60 mg...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：08113/AIM.0010
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:During the last 3 decades, Iran has experienced a rapid population growth and at the same time the health of Iranian people has improved greatly. This achievement was mainly due to training and availability of health manpower, well organized public health network and medical science and research improvement....
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Growth is an increase in the physical dimensions and its result is a quantitative change in the body. Development is a progressive increase in the skills and functional capacity of a child and its result is a qualitative change in a child's function. METHODS:This investigation was a descriptive, decompositi...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Primitive neuroectodermal tumors (PNETs) are a family of highly malignant soft tissue neoplasms mostly occurring in children and young adults. PNETs usually develop in the thoracopulmonary region, abdomen, pelvis, and rarely in the head and neck region. Here, a case of PNET located in the parotid gland is reported. ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151812/AIM.0012
更新日期：2015-12-01 00:00:00
abstract：:Hydatidosis is an important zoonotic parasite disease in several herbivorous mammals. Human cystic echinococcosis (CE) caused by infection with larval stage of Echinococcus granulosus has been frequently reported from different organs. Here, we report the first case of a urinary echinococcosis in Iran with a pain in t...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-08-01 00:00:00
abstract：:This article discusses the importance, definition, and types of confounders in epidemiology. Methods to identify and address confounding are discussed, as well as their strengths and limitations. The article also describes the difference among confounders, mediators, and effect modifiers. ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：012158/AIM.0014
更新日期：2012-08-01 00:00:00
abstract：:Vitamin D is a pro-hormone that plays an important role in body calcium regulation. Vitamin D toxicity occurs rarely due to its wide therapeutic index. A 38-year-old Iranian man was admitted to our hospital with a diagnosis of vitamin D toxicity. Laboratory test revealed hypercalcemia and elevated 25-hydroxyvitamin D ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0161908/AIM.0013
更新日期：2016-08-01 00:00:00
abstract：:Markers of bone turnover are becoming an important tool for practitioners in the management of osteoporosis. Therefore, it is essential to establish a reference database of the markers before using them in various clinical settings. A total of 785 individuals (37% males, 63% females) without apparent or suggested abno...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,多中心研究
doi：08112/AIM.0015
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Non-invasive ventilation (NIV) has brought about a significant change in care and treatment of respiratory distress syndrome (RDS) in very low birth weight (VLBW) neonates. The present study was designed and conducted to evaluate different strategies of initial respiratory support (IRS) in VLBW neonates hosp...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0172003/AIM.008
更新日期：2017-03-01 00:00:00
abstract：:Effective prevention and early diagnostic strategies are the most important public health interventions in gastric cancer, which remains a common malignancy worldwide. Preventive strategies require identification and understanding of environmental risk factors that lead to carcinogenesis. Helicobacter pylori (H. pylor...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：013166/AIM.0010
更新日期：2013-06-01 00:00:00
abstract：:The purpose of this article is to present the CT features in five cases of pathologically verified Inferior vena cava (IVC) leiomyosarcoma. In this retrospective analysis, we reviewed CT features in 5 cases of clinicopathologically confirmed IVC leiomyosarcoma with respect to its location (infra renal, trans renal, su...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141705/AIM.0014
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Helicobacter pylori isolates from 84 adults and 51 children were assessed during the period of 2001 through 2004 to find out whether their susceptibilities to metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone differ between the two groups or have changed compared with the results fro...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease caused by germline mutation in Adenomatous Polyposis Coli (APC) gene. FAP accounts less than 1% of all colorectal cancers incidence. Patients generally present hundreds to thousands of adenomas in colon and rectum and develop colorectal ca...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151807/AIM.0010
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has been widespread since late December 2019, with several symptoms related to the upper and lower respiratory system. However, its cardiac manifestations are less frequently studied. We aimed to analyze the available COVID-19 data on acute cardiac injury, using troponin a...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,meta分析
doi：10.34172/aim.2020.107
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Preventing violence is important especially in the Middle East, where many countries are struggling with violence. Knowing the affecting factors could help public policy makers to decrease violence level. Thus, this study is aimed to analyze health and other socio-economic factors that could affect interpers...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2020-02-01 00:00:00
abstract：:Intravenous drug abuse is an increasing social and health problem. Repeated injuries to the veins, injection of some types of insoluble substances, and needle sharing habits result in various complications. Increasing incidence of major vascular complications has been reported worldwide. The objective of this study wa...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：07104/AIM.0018
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Oxidative stress is involved in the pathophysiology of diabetes mellitus. METHODS:In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and g...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Breast cancer is the leading cause of carcinoma death in women. Proper treatment depends on the consideration of molecular biology status of tumor cells, which may determine the patient's treatment and prognosis. To determine the prognostic models for this disease, we evaluated the role of cell proliferation...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,多中心研究
doi：07101/AIM.008
更新日期：2007-01-01 00:00:00
abstract：:Following the establishment of Gastroenterology and Hepatology Fellowship Programs in 1987, significant developments in research and health care delivery have been achieved. The number of published articles has increased significantly and now more than 10 approved research centers are involved in several longitudinal ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:The present study was conducted to determine the health-related quality of life in patients living with human immunodeficiency virus or suffering from acquired immune deficiency syndrome (HIV/AIDS), referred to Behavioral Diseases Consultation Center in west of Tehran, Iran. METHODS:This cross-sectional stu...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：:Chronic myelogenous leukemia (CML) and tuberculosis (TB) are diseases with effective available therapy. Treating patients who are afflicted simultaneously with both of these conditions is challenging due to significant drug interactions and the requirement of strict adherence to the multi-agent treatment regimen. Here...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151801/AIM.0015
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Postmenopausal bleeding is a clinically important complaint in general gynecologic practice. The incidence of spontaneous postmenopausal bleeding in the general population is approximately 10 % immediately after menopause, and 5 % in all menopausal women. OBJECTIVES:The study was aimed to reveal the histopa...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0131611/AIM.0011
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Hepatitis delta virus is a unique human pathogen responsible for some 20 million infections globally. This virus is dependent on hepatitis B virus for transmission and propagation. Currently, at least three genotypes of hepatitis delta virus with different geographic distribution and clinical manifestations ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Human rotavirus genotypes G1-G4, G9, P[4] and P[8] are major worldwide causes of acute gastroenteritis in children. Rotavirus genotype G1P[8] is predominant in many countries. In this study, the genotypic diversity of group A rotaviruses were detected in children <5 years of age who were treated for dehydrat...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：011141/AIM.009
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:There is controversial data available regarding the impact of age at menarche on cardio-metabolic parameters. This community-based study aimed to assess this association among Iranian women. METHODS:We recruited 5,344 eligible women out of 7718, aged 10-50 years who participated in the Tehran lipid and gluc...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:In recent years the increasing use of nanoparticles has led researchers to study their effects on biological systems. The most important effects of nanoparticles on cells are their ability to induce or suppress production of reactive oxygen species (ROS). Changes in reactive oxygen species play an important ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151809/AIM.008
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Wrong beliefs about risky actions such as sunbathing and tanning are common due to media advertisements or general lack of knowledge. This work has focused on the knowledge and attitude of a group of citizens in Tehran, Iran and the protective actions they take regarding undesirable effects of the sun. M...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：011142/AIM.0011
更新日期：2011-03-01 00:00:00
abstract：:From ancient time leprosy has been regarded as a terrifying, stigmatized disease; nevertheless, its cause remained unidentified up to the late 19th century. For centuries numerous leprosy victims worldwide suffered from its morbidity and were socially isolated. The afflicted individuals were segregated because they we...
journal_title：Archives of Iranian medicine
pub_type： 历史文章,杂志文章
doi：011146/AIM.0014
更新日期：2011-11-01 00:00:00
