Abstract:
BACKGROUND:Hepatitis delta virus is a unique human pathogen responsible for some 20 million infections globally. This virus is dependent on hepatitis B virus for transmission and propagation. Currently, at least three genotypes of hepatitis delta virus with different geographic distribution and clinical manifestations are described. METHODS:In this study, hepatitis delta virus RNA of 35 patients' sera were analyzed by RT- semi-nested polymerase chain reaction. Based on genomic differences of hepatitis delta antigen coding region of hepatitis delta virus RNA among hepatitis delta virus RNA-positive sera, the polymerase chain reaction products were digested with restriction enzymes and studied by restriction fragment length polymorphism. RESULTS:Out of 35 samples, 13 (38.46%) were positive for hepatitis delta virus RNA by RT- semi-nested polymerase chain reaction. All polymorphisms were shown to be genotype I. Out of 13 hepatitis delta virus RNA-positive (13/35), eight were HBeAg negative. CONCLUSION:Our data indicated that hepatitis delta virus isolates in Tehran are exclusively genotype I.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Mirshafiee H,Mahmoodian-Shooshtari M,Sharifi Z,Hosseini SMsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
238-43issue
3eissn
1029-2977issn
1735-3947pii
09123/005journal_volume
12pub_type
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
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journal_title:Archives of Iranian medicine
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更新日期:2006-10-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
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journal_title:Archives of Iranian medicine
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更新日期:2015-01-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:Archives of Iranian medicine
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journal_title:Archives of Iranian medicine
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更新日期:2010-03-01 00:00:00
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更新日期:2020-02-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
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journal_title:Archives of Iranian medicine
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更新日期:2017-11-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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更新日期:2007-07-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2018-09-01 00:00:00
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更新日期:2010-07-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
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pub_type: 杂志文章
doi:012157/AIM.0011
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更新日期:2013-01-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
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journal_title:Archives of Iranian medicine
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:
更新日期:2009-09-01 00:00:00
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更新日期:2014-01-01 00:00:00