Abstract：
BACKGROUND:Alzheimer and Parkinson diseases (AD and PD) are the two most important neurodegenerative disorders. This paper aims to determine the possible molecular linkage between these two common neurodegenerative diseases by a combination of computational investigations. METHODS:According to our aim, common sets of identified proteins from the KEGG database were further analyzed based on Gene Ontology (GO) annotation and sequence similarities by the agglomerative hierarchical clustering. Proteins possessing same characteristics were categorized based on biological features in distinct clusters using the R programming software. In addition to this, by the use of DAVID Program and PPI network analysis, more insight can be achieved. RESULTS:The results of this study indicated that 23 proteins are common between these two diseases. Their ontology evaluations by application of clustering methods showed that proteins belonging to a specific cluster indicate discrete properties that are different from other clusters. Furthermore, PPI network analysis confirms that the proteins with similarity ontology and sequence are also in close relationship. CONCLUSION:In conclusion, assessment of protein features supported the idea that mitochondria are the main malfunction compartment in AD and PD. Some of these common properties are apoptosis and mitochondria oxidation pathways that can be used for drug targeting. Moreover, examination of other neurodegenerative diseases can be helpful for comprehensive understanding of the origin of these diseases.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Rezaei-Tavirani M,Zamanian-Azodi M,Rajabi S,Masoudi-Nejad A,Rostami-Nejad M,Rahmatirad Sdoi
0161902/AIM.007subject
Has Abstractpub_date
2016-02-01 00:00:00pages
101-9issue
2eissn
1029-2977issn
1735-3947pii
007journal_volume
19pub_type
杂志文章abstract：:Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease caused by germline mutation in Adenomatous Polyposis Coli (APC) gene. FAP accounts less than 1% of all colorectal cancers incidence. Patients generally present hundreds to thousands of adenomas in colon and rectum and develop colorectal ca...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151807/AIM.0010
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Our aim was to determine the association between age at menarche (AAM) and breast cancer adjusted for recall bias (misclassification) in AAM. METHODS:We have used data provided from a case-control study conducted in Iran from 2005 to 2009. The cases and controls were frequency matched based on 5-year age gr...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-02-01 00:00:00
abstract：:Vitamin D is a pro-hormone that plays an important role in body calcium regulation. Vitamin D toxicity occurs rarely due to its wide therapeutic index. A 38-year-old Iranian man was admitted to our hospital with a diagnosis of vitamin D toxicity. Laboratory test revealed hypercalcemia and elevated 25-hydroxyvitamin D ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0161908/AIM.0013
更新日期：2016-08-01 00:00:00
abstract：:The history of early attempts of blood transfusion in Iran traces back to the 1940s; however, around three decades later in 1974, the Iranian National Blood Transfusion Service (Sazeman-e Melli-e Enteqal-e Khun-e Iran) was founded by the outstanding hematologist, Professor Fereydoun Ala. The main goals of this central...
journal_title：Archives of Iranian medicine
pub_type： 传,历史文章,杂志文章
doi：015186/AIM.0016
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Suicide is among the top 20 leading causes of death globally in all age groups and it is still a significant social and public health problem. METHODS:Data on suicide deaths in 1987-2011 were extracted from the Turkish Statistical Institute mortality dataset based on ICD-9 and ICD-10 codes. The temporal tre...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：015186/AIM.006
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome is not uncommon in women of reproductive age. We conducted this study to determine the clinical, hormonal, and biochemical effects of metformin therapy on girls with polycystic ovary syndrome. METHODS:In a self-controlled clinical trial conducted at the Gynecology Center of Yahyane...
journal_title：Archives of Iranian medicine
pub_type： 临床试验,杂志文章
doi：07102/AIM.0010
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:EBOV outbreaks continue to threaten the world due to the absence of effective vaccines and therapeutics. Easy-to-use and rapid diagnostic tests for EBOV are highly desired for prevention and control of the EVD epidemic. METHODS:Escherichia coli expression system was used to express VP40 protein of Zaire Ebo...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0172004/AIM.0011
更新日期：2017-04-01 00:00:00
abstract：:The primary goal of therapy in patients with chronic hepatitis B is suppression and long-lasting maintenance of hepatitis B virus DNA to its lowest possible level. The threshold of hepatitis B virus DNA level for therapy is > or = 10(5) copies/mL for HBeAg-positive patients and > or = 10(4) for those with HBeAg-negati...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:As there is a significant number of Iranian immigrant and illegal refugees living in marginal areas of large cities that might induce immunization gap in these areas. The aim of this study was to provide reliable information on vaccination status of these people. A cross sectional study was conducted on children 24-4...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141710/AIM.0011
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The need for mental health care among children and adolescents in Iran, as in other low and middle income countries (LAMIC) remains mostly unmet. In this paper, we sought to provide an overview of the extent of unmet need and mental health services in Iran. We also aimed to propose approaches to address this...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0161911/AIM.0010
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:The Consolidated Standards for Reporting of Trials (CONSORT) statement is a device to standardize reporting and improve the quality of controlled trials. The aim of this study is to determine the quality of controlled clinical trial reports by national peer-reviewed journals in Iran. METHODS:In a cross-sect...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013161/AIM.007
更新日期：2013-01-01 00:00:00
abstract：:Synchronous development of gastrointestinal stromal tumors with other tumors in the digestive tract is relatively rare, and often occurs in the stomach. We report a 76-year-old woman, who suffered from the exceedingly rare synchronous development of small intestinal stromal tumor and cecal adenocarcinoma. The patient ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E. METHODS:Rats were randomly assigned to 4 groups: normal control, doxorubicin inducted control, eicosapentaenoic acid tre...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Physical inactivity is one of the leading causes of major chronic disease, which contributes substantially to the global burden of disease, death and disability. This study examined physical activity in a randomly selected sample of elderly people in Tehran, Iran. METHODS:A random sample of 400 elderly peop...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：010136/0014
更新日期：2010-11-01 00:00:00
abstract：:Hereditary spherocytosis (HS), a familial defect involving red blood cell (RBC) membrane proteins, is associated with reduced deformability, increased fragility, and progressive destruction of spherical cells. The present study focuses on three subjects of a family showing a history of repeated episodes of lethargy an...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2020-03-01 00:00:00
abstract：:Seizures are common in children and 5% of all medical attendances to accident and emergency departments are related to seizures. The role of emergent neuroimaging for those children with first afebrile seizure is, however, not well-defined. We reviewed medical charts of 125 children who were admitted with a new-onset ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:It is suggested that pregnancy-associated plasma protein-A (PAPP-A) levels below the fifth percentile or less than 0.4 multiples of the median (MoMs) during the first trimester are closely associated with higher risk for neonatal abnormalities. We assessed the value of PAPP-A within the first trimester for p...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Calculation of burden of diseases and risk factors is crucial to set priorities in the health care systems. Nevertheless, the reliable measurement of mortality rates is the main barrier to reach this goal. Unfortunately, in many developing countries the vital registration system (VRS) is either defective or ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141703/AIM.007
更新日期：2014-03-01 00:00:00
abstract：:Intravenous drug abuse is an increasing social and health problem. Repeated injuries to the veins, injection of some types of insoluble substances, and needle sharing habits result in various complications. Increasing incidence of major vascular complications has been reported worldwide. The objective of this study wa...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：07104/AIM.0018
更新日期：2007-10-01 00:00:00
abstract：:On January 23, 2020, the Chinese government announced the city lockdown of Wuhan. Since then, there have been controversial debates among experts about the efficacy of mass quarantine, the oldest and probably one of the most effective methods for controlling infectious disease outbreaks. The impact of health policymak...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：10.34172/aim.2020.08
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Neuropsychological manifestations are present in 60% of patients with Systemic Lupus Erythematosus (SLE) among which cognitive dysfunction is the most common. This study aims to determine the prevalence of cognitive disorders in SLE patients, and the relationship between cognitive disorder domains and depres...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0161904/AIM.006
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Postmenopausal bleeding is a clinically important complaint in general gynecologic practice. The incidence of spontaneous postmenopausal bleeding in the general population is approximately 10 % immediately after menopause, and 5 % in all menopausal women. OBJECTIVES:The study was aimed to reveal the histopa...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0131611/AIM.0011
更新日期：2013-11-01 00:00:00
abstract：:Esophageal cancer (EC) is the 8th most common cancer and the 6th most frequent cause of cancer mortality worldwide. Esophageal squamous cell carcinoma (ESCC) is the most common type of EC. Exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested as a risk factor for developing ESCC. In this paper we will...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：0121511/AIM.0013
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Psoriasis (Ps) is a chronic skin disease that can lead to negative impacts on quality of life (QoL) because of diseaserelated comorbidities. We aimed to investigate the risk of obstructive sleep apnea syndrome (OSAS) in patients with Ps. METHODS:Fifty-seven patients with Ps were included in this study. The ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Many families are directly involved in caring of their children with the lifelong autistic spectrum disorders. Sometimes, they are the victims of their children's behaviors. The family, including siblings, may have to explain the children's behaviors to others. Their mothers have poorer mental health with difficulties...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:The present study aimed to evaluate the correlation of P53 and granzyme B (GB) expression, and also the relationship between P53 expression and GB+ cell density with lymph node metastasis, histologic grade, and inflammation intensity in oral squamous cell carcinoma (OSCC). METHODS:Immunohistochemical techn...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013169/AIM.003
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Ankylosing spondylitis (AS; OMIM:106300) is a common complex inflammatory disease; in a previous study, we introduced a novel mutation in the RELN gene (OMIM: 600514) which was associated with AS. This study is designed to investigate the potential effect of RELN S2486G mutation on reelin secretion; addition...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：10.34172/aim.2020.87
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The standard treatment for decompensated liver cirrhosis is liver transplantation. However, it has several limitations. Recent animal studies suggest that bone marrow stem cell transplantation can lead to regression of liver fibrosis. The objective of this study was to determine the safety and feasibility of...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：07104/AIM.008
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Hepatitis delta virus is a unique human pathogen responsible for some 20 million infections globally. This virus is dependent on hepatitis B virus for transmission and propagation. Currently, at least three genotypes of hepatitis delta virus with different geographic distribution and clinical manifestations ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:We aimed to examine cases of brucellosis that presented with severe thrombocytopenia and hemorrhagic diathesis. METHODS:A total of 10 brucellosis cases with severe thrombocytopenia were included in this case-series study. Patients' files were reviewed for their clinical and laboratory findings, as well as c...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：012155/AIM.0011
更新日期：2012-05-01 00:00:00
