Abstract:
BACKGROUND:Estrogen is the major sex steroid affecting the growth, remodeling, and homeostasis of the female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, muscles, and menisci in ovariectomized rats. METHODS:Fifteen rats were randomized into three groups of five animals each. The first group was the control group with no additional surgical procedure, but the rest (groups 2 and 3) were bilaterally ovariectomized . All animals in the group 2 were sacrificed at 14th week to evaluate the short- term effect, and all of other animals in the groups 1 and 3 were sacrificed at 28th week to analyze the long- term effect of estrogen loss in the ovariectomized group and to control with the group 1. Quadriceps muscles, Achilles tendons, menisci, and femur cortical bones from both lower extremities were taken. The amount of apoptosis was measured. RESULTS:There was a significant increase in cell apoptosis in bones, muscles, and tendons with insignificant increase in cell apoptosis in menisci at early and late periods in rats with ovariectomies than the control. CONCLUSION:The results indicated that estrogen loss after ovariectomy does not only affect bones; it may also increase cell apoptosis in different tissues such as muscles, tendons, and menisci.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Aydin A,Kenar H,Atmaca H,Alici T,Gacar G,Müezzinoğlu ÜS,Karaöz Edoi
013165/AIM.006subject
Has Abstractpub_date
2013-05-01 00:00:00pages
271-6issue
5eissn
1029-2977issn
1735-3947pii
006journal_volume
16pub_type
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