Abstract：
BACKGROUND:Polycystic ovary syndrome is not uncommon in women of reproductive age. We conducted this study to determine the clinical, hormonal, and biochemical effects of metformin therapy on girls with polycystic ovary syndrome. METHODS:In a self-controlled clinical trial conducted at the Gynecology Center of Yahyanejad Hospital, affiliated to Babol University of Medical Sciences, Babol, North of Iran, 36 girls with polycystic ovary syndrome were studied. The patients were treated with 500 mg of metformin three times a day for six months. Clinical symptoms, menstrual pattern, and hirsutism, as well as serum concentration of sex steroid (follicular stimulating hormone, luteinizing hormone, dihydroepiandrosterone, testosterone, 17-OH progesterone, estradiol), and lipids (triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein) were assessed pre- and posttreatment. RESULTS:Sixteen girls (53% of those with menstrual disturbances) experienced more regular cycles during the treatment. A significant decrease in weight (P = 0.004) and body mass index (P = 0.006) was noticed after six months of treatment. The number of patients with hirsutism was also decreased. The mean levels of triglyceride (P = 0.03) and low-density lipoprotein (P = 0.0.01) were decreased while high density lipoprotein (P = 0.003) was increased significantly. We also found a significant decrease in luteinizing hormone (P = 0.006), estradiol (P = 0.005), and dihydroepi-androsterone (P = 0.026) after treatment. Changes in the follicular stimulating hormone and 17-OH progesterone levels were not significant. CONCLUSION:Metformin therapy has many useful effects in these patients.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Nazari T,Bayat R,Hamedi Mdoi
07102/AIM.0010subject
Has Abstractpub_date
2007-04-01 00:00:00pages
176-81issue
2eissn
1029-2977issn
1735-3947pii
0010journal_volume
10pub_type
临床试验,杂志文章abstract：:Primitive neuroectodermal tumors (PNETs) are a family of highly malignant soft tissue neoplasms mostly occurring in children and young adults. PNETs usually develop in the thoracopulmonary region, abdomen, pelvis, and rarely in the head and neck region. Here, a case of PNET located in the parotid gland is reported. ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151812/AIM.0012
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abstract：BACKGROUND:Non-invasive ventilation (NIV) has brought about a significant change in care and treatment of respiratory distress syndrome (RDS) in very low birth weight (VLBW) neonates. The present study was designed and conducted to evaluate different strategies of initial respiratory support (IRS) in VLBW neonates hosp...
journal_title：Archives of Iranian medicine
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doi：0172003/AIM.008
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abstract：BACKGROUND:Human rotavirus has now been established as the most important cause of childhood gastroenteritis worldwide. The RNA genomic electrophoretic diversity of group A rotavirus strains in Tehran, Iran, during April 2002 through March 2005, was investigated in 1250 stool specimens. METHODS:Stool samples were obta...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：
更新日期：2017-11-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：
更新日期：2009-03-01 00:00:00
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doi：012158/AIM.0014
更新日期：2012-08-01 00:00:00
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更新日期：2014-07-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2006-04-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：
更新日期：2009-05-01 00:00:00
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更新日期：2015-02-01 00:00:00
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更新日期：2014-08-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：
更新日期：2018-09-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：014176/AIM.0011
更新日期：2014-06-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2018-08-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0121512/AIM.0010
更新日期：2012-12-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：
更新日期：2019-07-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章,随机对照试验
doi：012158/AIM.004
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:The current study aimed to evaluate the mechanisms involved in protection against doxorubicin-induced cardiac and renal toxicities upon treatment with eicosapentaenoic acid and vitamin E. METHODS:Rats were randomly assigned to 4 groups: normal control, doxorubicin inducted control, eicosapentaenoic acid tre...
journal_title：Archives of Iranian medicine
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doi：
更新日期：2018-11-01 00:00:00
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pub_type： 杂志文章
doi：0161901/AIM.0011
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journal_title：Archives of Iranian medicine
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doi：
更新日期：2019-09-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2019-12-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0141701/AIM.0015
更新日期：2014-01-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：0141709/AIM.009
更新日期：2014-09-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013161/AIM.007
更新日期：2013-01-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：012157/AIM.0011
更新日期：2012-07-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151801/AIM.0015
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:There is a lack of data regarding the incidence rate, etiology, risk factors, and natural course of thyroid disorders and their relationship with cardiovascular disease and mortality in populations undergoing nutrition transition. Therefore, we aimed to assess the natural course of thyroid disease in Tehrani...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
