Abstract:
BACKGROUND:The present study aimed to evaluate the correlation of P53 and granzyme B (GB) expression, and also the relationship between P53 expression and GB+ cell density with lymph node metastasis, histologic grade, and inflammation intensity in oral squamous cell carcinoma (OSCC). METHODS:Immunohistochemical technique with P53 and GB antibodies were performed on stored paraffin blocks from 48 patients with OSCC (with lymph node metastasis n = 24; without lymph node metastasis n = 24). The density of GB expression was quantified both in invasive front (peritumoral ) and within cancer nests (intratumoral ). RESULTS:P53 positivity was seen in 13 (54.16%) cases of the nonmetastatic group and 14 cases (58.3%) in the metastatic group. A significant correlation was seen between P53 immunoexpression and histologic grade (P = 0.047), but there was no significant correlation between P53 expression with lymph node metastasis and inflammation intensity. The density of GB+ cells in the peritumoral zone correlates with a higher intratumoral GB expression (P = 0.001) and was significantly higher in the nonmetastatic group (P = 0.029). No significant correlation between GB and P53 immunoexpression, lymph node metastasis, or inflammation intensity was seen. CONCLUSION:The present study showed that the presence of a higher density of GB+ cells infiltrating the peritumoral area may have an important role against tumoral cells, prevent lymph node metastasis, and better prognosis in OSCC patients.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Taghavi N,Khaleghjou A,Mahdavi Ndoi
013169/AIM.003subject
Has Abstractpub_date
2013-09-01 00:00:00pages
498-502issue
9eissn
1029-2977issn
1735-3947pii
003journal_volume
16pub_type
杂志文章abstract::Systemic therapy is one of the cornerstones of cancer treatment. In 1972, following representations by American Society of Clinical Oncology (ASCO), the American Board of Internal Medicine (ABIM) recognized medical oncology as a new subspecialty of internal medicine. Subspecialty of Hematology and Medical Oncology was...
journal_title:Archives of Iranian medicine
pub_type: 历史文章,杂志文章
doi:0151811/AIM.0013
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Advanced computed tomography (CT) scanners enable concurrent assessment of coronary artery anatomy and myocardial perfusion. The purpose of this study was to assess dual-energy CT images in a group of patients suspected for ischemic heart disease and to evaluate agreement of cardiac computed tomography perfu...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-07-01 00:00:00
abstract::Adrenal cysts are rare lesions which are usually nonfunctional and asymptomatic. Adrenal pseudocysts do not have epithelial linings and account for about 40% of adrenal cysts. We report a case of giant adrenal pseudocyst in a 32 year old woman presenting with flank pain who had undergone surgical excision. ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0131612/AIM.0012
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Growth is an increase in the physical dimensions and its result is a quantitative change in the body. Development is a progressive increase in the skills and functional capacity of a child and its result is a qualitative change in a child's function. METHODS:This investigation was a descriptive, decompositi...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Postmenopausal bleeding is a clinically important complaint in general gynecologic practice. The incidence of spontaneous postmenopausal bleeding in the general population is approximately 10 % immediately after menopause, and 5 % in all menopausal women. OBJECTIVES:The study was aimed to reveal the histopa...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0131611/AIM.0011
更新日期:2013-11-01 00:00:00
abstract::Primitive neuroectodermal tumors are fairly rare in uterus. A case of uterine body primitive neuroectodermal tumor in a 32-year-old Iranian woman is presented. The patient was admitted with abdominal pain and fever and underwent emergency exploratory surgery with total abdominal hysterectomy, bilateral salpingo-oophor...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:015184/AIM.0014
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:It is well known that inhalation of chemical warfare, mostly sulfur mustard, causes injury of the respiratory system. Chronic obstructive pulmonary disease is a common disease among these patients. Health-related quality of life is a common feature of studies in chronic obstructive pulmonary disease. The obj...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::Vitamin D is a pro-hormone that plays an important role in body calcium regulation. Vitamin D toxicity occurs rarely due to its wide therapeutic index. A 38-year-old Iranian man was admitted to our hospital with a diagnosis of vitamin D toxicity. Laboratory test revealed hypercalcemia and elevated 25-hydroxyvitamin D ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161908/AIM.0013
更新日期:2016-08-01 00:00:00
abstract::Nationwide implementation of Family Physician (FP) program started in 2005 and targeted almost 25,000,000 citizens residing in rural areas and cities with less than 20,000 populations in Iran. Despite its blatant initiation that resulted in some modest achievements, the future of FP looks unclear in Iran. Thus far, no...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141711/AIM.0012
更新日期:2014-11-01 00:00:00
abstract::The purpose of this article is to present the CT features in five cases of pathologically verified Inferior vena cava (IVC) leiomyosarcoma. In this retrospective analysis, we reviewed CT features in 5 cases of clinicopathologically confirmed IVC leiomyosarcoma with respect to its location (infra renal, trans renal, su...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141705/AIM.0014
更新日期:2014-05-01 00:00:00
abstract::Primitive neuroectodermal tumors (PNETs) are a family of highly malignant soft tissue neoplasms mostly occurring in children and young adults. PNETs usually develop in the thoracopulmonary region, abdomen, pelvis, and rarely in the head and neck region. Here, a case of PNET located in the parotid gland is reported. ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0151812/AIM.0012
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Alzheimer and Parkinson diseases (AD and PD) are the two most important neurodegenerative disorders. This paper aims to determine the possible molecular linkage between these two common neurodegenerative diseases by a combination of computational investigations. METHODS:According to our aim, common sets of ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161902/AIM.007
更新日期:2016-02-01 00:00:00
abstract::Following the establishment of Gastroenterology and Hepatology Fellowship Programs in 1987, significant developments in research and health care delivery have been achieved. The number of published articles has increased significantly and now more than 10 approved research centers are involved in several longitudinal ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:
更新日期:2009-09-01 00:00:00
abstract::Heterotopic neuroglial tissue, composed of differentiated neuroectodermal tissue, represents developmental heterotopia of neuroglial tissue rather than true neoplasm. Herein, we present a patient with nasopharyngeal heterotopic neuroglial tissue who presented with respiratory distress and feeding difficulty in early d...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:The present study was conducted to determine the health-related quality of life in patients living with human immunodeficiency virus or suffering from acquired immune deficiency syndrome (HIV/AIDS), referred to Behavioral Diseases Consultation Center in west of Tehran, Iran. METHODS:This cross-sectional stu...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::Septic arthritis is a fearful condition because of its mortality and the potentially late sequels on immature skeleton including limb shortening, osteomyelitis, destruction of joint surface, severe limitation of motion, and dislocation.This study was performed to reveal the final outcome of our patients and find out t...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::Effective prevention and early diagnostic strategies are the most important public health interventions in gastric cancer, which remains a common malignancy worldwide. Preventive strategies require identification and understanding of environmental risk factors that lead to carcinogenesis. Helicobacter pylori (H. pylor...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:013166/AIM.0010
更新日期:2013-06-01 00:00:00
abstract::Fibrodysplasia ossificans progressiva is a rare and disabling syndrome, which is characterized by heterotopic ossifications and skeletal deformities. So far, around 200 patients with fibrodysplasia ossificans progressiva have been reported in the world literature. Herein, we analyze the clinical records of 7 known cas...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,多中心研究
doi:07101/AIM.0018
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:This research aims to determine the mental health status of population aged 15 and over in the province of Chaharmahal and Bakhtiari in 2015. METHODS:The statistical population of this cross-sectional field survey consisted of residents of urban and rural areas of Chaharmahal and Bakhtiari in Iran. An est...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Many risk factors have been investigated in multiple sclerosis (MS); however, few studies have focused on the association between risk factors and the disease severity. The aim of our study was to evaluate the association between some of these risk factors and MS severity in a population sample of Iranian pa...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161912/AIM.007
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:This study was conducted to evaluate the hematological effects of umbilical cord clamp timing and delivery type in term infants 48 hours after birth in Imam Hossein Hospital, Tehran, Iran. METHOD:From Oct 2007 - March 2008, 100 mother-infant eligible pairs were selected and divided by cord clamp timing (< or...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:010135/AIM.0010
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:It is known that there is an association between elevated total plasma homocysteine level and restenosis after percutaneous coronary angioplasty. OBJECTIVE:To evaluate the effect of lowering plasma homocysteine levels on the rate of restenosis after stent-percutaneous coronary angioplasty. METHODS:Folic ac...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Chorionic Villous Sampling (CVS) is a diagnostic method for determining genetic disorders. The present study aimed to determine the negative predictive value of the CVS in the diagnosis of major thalassemia in genetic laboratory of Dastgheib Hospital, Shiraz, Iran. METHODS:The present research was an evalua...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141707/AIM.007
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:It is suggested that pregnancy-associated plasma protein-A (PAPP-A) levels below the fifth percentile or less than 0.4 multiples of the median (MoMs) during the first trimester are closely associated with higher risk for neonatal abnormalities. We assessed the value of PAPP-A within the first trimester for p...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION:Successful isolation of mesenchymal stem cells from waste tissues might be extremely promising for developing stem cell-based therapies. This study aimed to explore whether cells retrieved from teeth extracted due to advanced periodontal disease present mesenchymal stem cell-like properties. METHODS:Pulp ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:015184/AIM.004
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The childhood obesity epidemic is one of the most serious global health challenges, and many relevant policies have been designed and implemented. Regarding health equity policy-making, it is important to adopt proper interventional strategies, including childhood obesity policies. The purpose of this study ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-11-01 00:00:00
abstract::The primary goal of therapy in patients with chronic hepatitis B is suppression and long-lasting maintenance of hepatitis B virus DNA to its lowest possible level. The threshold of hepatitis B virus DNA level for therapy is > or = 10(5) copies/mL for HBeAg-positive patients and > or = 10(4) for those with HBeAg-negati...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The threshold of thyroid-stimulating hormone (TSH) in current screening for congenital hypothyroidism (CH) from the heel prick test is 5 mU/l. This study uses cost-effective analysis to evaluate increasing the threshold to minimize false-positive results and recall rates. METHODS:Cost of screening, diagnosi...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012153/AIM.006
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Unprotected sexual activity is an important reason for the currently growing incidence of HIV infection in Iran. Recognizing barriers to safe sexual practice and affordance of behavioral changes can improve planning for condom promotion. The main objective of our study is to evaluate the opinions of HIV-posi...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0121512/AIM.0010
更新日期:2012-12-01 00:00:00
abstract::Placental mesenchymal dysplasia is a rare condition of the placenta and its true incidence and underlying cause has remained unknown till now due to its rarity. Its accurate diagnosis is essential, because placental mesenchymal dysplasia is usually compatible with a good fetal and maternal outcome. A precise ultrasono...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013169/AIM.0013
更新日期:2013-09-01 00:00:00