Abstract:
BACKGROUND:The threshold of thyroid-stimulating hormone (TSH) in current screening for congenital hypothyroidism (CH) from the heel prick test is 5 mU/l. This study uses cost-effective analysis to evaluate increasing the threshold to minimize false-positive results and recall rates. METHODS:Cost of screening, diagnosis and treatment, education, and care of mentally retarded patients were gathered from the Ministry of Health State Welfare Organization and Department of Education in Tehran. Screening data were obtained from 34,007 neonates in the Central Health Laboratory of Tehran University of Medical Sciences in 2009. Sensitivity analysis and calculation of confidence interval for incremental costs and effects (gained disability adjusted life years - DALYs) and incremental cost-effectiveness ratios (ICER) were performed by Monte Carlo simulation with Ersatz software. RESULTS:ICER for screening programs with different TSH cut-off points versus no screening was similar, and approximately -4.5 ± 0.2 thousand US dollars per gained DALY. In the proposed cohort (10,000 neonates), gained DALYs were 316 ± 50 for a cut off point of 5 mU/l, 251 ± 40 for 10 mU/l, 146 ± 23 for 15 mU/l, and 113 ± 18 for a cut-off point of 20 mU/l. Sensitivity analysis showed that the model remained the same when the input parameters were changed. CONCLUSION:This study demonstrates that the current threshold of TSH in the national CH screening program in terms of cost-effectiveness is the most appropriate threshold. However, more studies are needed to examine new strategies and methods to reduce recall rates and related consequences such as repeated thyroid testing in neonates.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Shamshiri AR,Yarahmadi S,Forouzanfar MH,Haghdoost AA,Hamzehloo G,Holakouie Naieni Kdoi
012153/AIM.006subject
Has Abstractpub_date
2012-03-01 00:00:00pages
136-41issue
3eissn
1029-2977issn
1735-3947pii
006journal_volume
15pub_type
杂志文章abstract:INTRODUCTION:Successful isolation of mesenchymal stem cells from waste tissues might be extremely promising for developing stem cell-based therapies. This study aimed to explore whether cells retrieved from teeth extracted due to advanced periodontal disease present mesenchymal stem cell-like properties. METHODS:Pulp ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:015184/AIM.004
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Consumption of white rice has been proposed as a dietary risk factor for development of metabolic disorders and type 2 diabetes, especially in populations who consume white rice as a staple food. In this study, we investigated the association between consumption of white rice and the occurrence of metabolic ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:014176/AIM.0011
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The probiotic microorganisms are live normal flora that provide nutritional benefits. When probiotic administered in adequate amounts, they also confer a health benefit on the host. Different mechanisms of probiotic effects include the following: stimulating the immune system, modifying the composition of no...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0151803/AIM.006
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:The present study was conducted to determine the health-related quality of life in patients living with human immunodeficiency virus or suffering from acquired immune deficiency syndrome (HIV/AIDS), referred to Behavioral Diseases Consultation Center in west of Tehran, Iran. METHODS:This cross-sectional stu...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::Nationwide implementation of Family Physician (FP) program started in 2005 and targeted almost 25,000,000 citizens residing in rural areas and cities with less than 20,000 populations in Iran. Despite its blatant initiation that resulted in some modest achievements, the future of FP looks unclear in Iran. Thus far, no...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141711/AIM.0012
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:In recent years the increasing use of nanoparticles has led researchers to study their effects on biological systems. The most important effects of nanoparticles on cells are their ability to induce or suppress production of reactive oxygen species (ROS). Changes in reactive oxygen species play an important ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0151809/AIM.008
更新日期:2015-09-01 00:00:00
abstract::The coronavirus infection is an evolving pandemic with high morbidity and mortality, especially in people with comorbidities. The case fatality rate (CFR) is 9.2% in the presence of diabetes, while it is 1.4% in those without any comorbidity. Diabetes is a prevalent disease globally; hence, healthcare professionals ar...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:10.34172/aim.2020.61
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Estrogen is the major sex steroid affecting the growth, remodeling, and homeostasis of the female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, muscles, and menisci in ovariecto...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013165/AIM.006
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Polycystic ovary syndrome is not uncommon in women of reproductive age. We conducted this study to determine the clinical, hormonal, and biochemical effects of metformin therapy on girls with polycystic ovary syndrome. METHODS:In a self-controlled clinical trial conducted at the Gynecology Center of Yahyane...
journal_title:Archives of Iranian medicine
pub_type: 临床试验,杂志文章
doi:07102/AIM.0010
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:This study ascertained the effects of soy, in the forms of textured soy protein (TSP) and soy nuts, on lipid profiles, apolipoproteins, inflammatory and prothrombotic markers, and blood pressure in elderly women diagnosed with metabolic syndrome (MetS). METHODS:This was a 12-week parallel, randomized, contr...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
doi:012158/AIM.004
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Wrong beliefs about risky actions such as sunbathing and tanning are common due to media advertisements or general lack of knowledge. This work has focused on the knowledge and attitude of a group of citizens in Tehran, Iran and the protective actions they take regarding undesirable effects of the sun. M...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:011142/AIM.0011
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Hepatitis delta virus is a unique human pathogen responsible for some 20 million infections globally. This virus is dependent on hepatitis B virus for transmission and propagation. Currently, at least three genotypes of hepatitis delta virus with different geographic distribution and clinical manifestations ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract::Synchronous development of gastrointestinal stromal tumors with other tumors in the digestive tract is relatively rare, and often occurs in the stomach. We report a 76-year-old woman, who suffered from the exceedingly rare synchronous development of small intestinal stromal tumor and cecal adenocarcinoma. The patient ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:This study determined the importance of including tests for refractive errors in vision screening. METHODS:In this cross-sectional study, we performed a random cluster sampling of schoolchildren in the city of Dezful, Iran. After sampling and obtaining informed written consents from their parents, children ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0011144/AIM.005
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:It is known that there is an association between elevated total plasma homocysteine level and restenosis after percutaneous coronary angioplasty. OBJECTIVE:To evaluate the effect of lowering plasma homocysteine levels on the rate of restenosis after stent-percutaneous coronary angioplasty. METHODS:Folic ac...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2006-04-01 00:00:00
abstract::Infection-associated hemophagocytic syndrome is a life-threatening condition characterized by prolonged fever, hepatosplenomegaly, and cytopenia-most commonly, thrombocytopenia and anemia. It is characterized by proliferation and activation of benign histiocytes, causing dysfunction of various organs. Herein, we repor...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::This study assessed changes in global and regional systolic left ventricular function after successful percutaneous recanalization of coronary artery occlusions. A consecutive series of 110 patients with mean+/-SD age of 53.6+/-9.1 years, in whom a complete angiographic evaluation was available before angioplasty, und...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:07103/AIM.0020
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Co-occurring methamphetamine (METH) use during methadone maintenance therapy (MMT) is a highly prevalent and progressive problem in Iran. There are no registered pharmacological treatments for treating METH use disorder. The present study investigates the potential efficacy of atomoxetine in the treatment of...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:HIV infection affects all body organs including kidney. Since the frequency of HIV-related renal disorders is unknown in Iran and the number of HIV-infected patients is increasing, this study was conducted for the first time in Iran to assess the frequency of electrolyte imbalance, renal failure, and protein...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:07103/AIM.0010
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION:Lynch Syndrome (LS) is a genetically inherited autosomal disorder that increases the risk of many types of cancer, especially colorectal cancer (CRC). Identifying these subjects improves morbidity and mortality. We aimed to assess the prevalence of LS with both clinical criteria and universal strategy in M...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,多中心研究
doi:0172006/AIM.003
更新日期:2017-06-01 00:00:00
abstract::Chronic ulcers of the oral mucosa are the lesions which a physician comes across frequently. "Eosinophilic Ulcer" is a rare variety of that. Eosinophilic ulcer or traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a chronic benign lesion of the oral mucosa and is a relatively recent delineated entity....
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141701/AIM.0015
更新日期:2014-01-01 00:00:00
abstract::This paper presents a systematic literature review of studies that shed light on the health of migrants in Iran from the perspective of social justice. A systematic search was conducted in PubMed and Iranian databases, including IranMedex, Magiran, and SID, in June 2012. All studies that were published until June 2012...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:0161910/AIM.0012
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The present study reported a six-year follow up of patients with chronic myeloid leukemia who were on imatinib therapy. METHODS:We performed a retrospective study on a total of 417 patients diagnosed with chronic-phase, Philadelphia-positive (Ph+) chronic myeloid leukemia within six months before study entr...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:011146/AIM.004
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:we aimed to recap and highlight the major results of the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 by mortality and morbidity to clarify the current health priorities and challenges in Iran. METHODS:We estimated Iran's mortality and burden of 289 diseases with 67 risk factors and 1160...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0141705/AIM.004
更新日期:2014-05-01 00:00:00
abstract:: Intellectual Disability (ID, also known as mental retardation) is a debilitating neurodevelopmental disorder affecting nearly 1% of the general population worldwide. Occurrence of behavioral disorders in individuals with ID is four times higher than that in the general population. An increasing number of studies seek...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,评审
doi:0161905/AIM.0012
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Oxidative stress is involved in the pathophysiology of diabetes mellitus. METHODS:In the present study, 68 patients with type 2 diabetes mellitus and 31 clinically healthy individuals were evaluated. The patients were divided into two groups. Group 1 included 29 patients without diabetic complications and g...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract::From ancient time leprosy has been regarded as a terrifying, stigmatized disease; nevertheless, its cause remained unidentified up to the late 19th century. For centuries numerous leprosy victims worldwide suffered from its morbidity and were socially isolated. The afflicted individuals were segregated because they we...
journal_title:Archives of Iranian medicine
pub_type: 历史文章,杂志文章
doi:011146/AIM.0014
更新日期:2011-11-01 00:00:00
abstract::Vitamin D is a pro-hormone that plays an important role in body calcium regulation. Vitamin D toxicity occurs rarely due to its wide therapeutic index. A 38-year-old Iranian man was admitted to our hospital with a diagnosis of vitamin D toxicity. Laboratory test revealed hypercalcemia and elevated 25-hydroxyvitamin D ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161908/AIM.0013
更新日期:2016-08-01 00:00:00
abstract::Adrenal cysts are rare lesions which are usually nonfunctional and asymptomatic. Adrenal pseudocysts do not have epithelial linings and account for about 40% of adrenal cysts. We report a case of giant adrenal pseudocyst in a 32 year old woman presenting with flank pain who had undergone surgical excision. ...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0131612/AIM.0012
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Thalassemia major and its treatment by stem cell transplantation can have deleterious effects on bone integrity. This study assesses the adverse effects of transplantation on growing bones of pediatric thalassemic patients. METHODS:Bone mineral density (BMD) of 20 patients from three thalassemia classes who...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013162/AIM.008
更新日期:2013-02-01 00:00:00