Abstract:
INTRODUCTION:Successful isolation of mesenchymal stem cells from waste tissues might be extremely promising for developing stem cell-based therapies. This study aimed to explore whether cells retrieved from teeth extracted due to advanced periodontal disease present mesenchymal stem cell-like properties. METHODS:Pulp cells were isolated from 15 intact molars and 15 teeth with advanced periodontal disease. Cell proliferation and markers of mesenchymal stem cells were evaluated. RESULTS:Based on the RT-PCR and agarose gel electrophoresis, nucleostemin, Oct-4 and jmj2c, but not Nanog, were expressed in undifferentiated mesenchymal stem cells of both groups. Interestingly, diseased pulp exhibited higher gene expressions although it was not statistically significant. The average percentage of BrdU positive cells in the diseased group (84.4%, n = 5) was significantly higher than that of the control group (65.4%, n = 5) (t-test, P = 0.001). CONCLUSION:Our results indicate the successful isolation of mesenchymal stem cells from the pulp tissue of hopeless periodontally involved teeth.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Derakhshani A,Raoof M,Dabiri S,Farsinejad AR,Gorjestani H,Yaghoobi MM,Shokouhinejad N,Ehsani Mdoi
015184/AIM.004subject
Has Abstractpub_date
2015-04-01 00:00:00pages
211-7issue
4eissn
1029-2977issn
1735-3947pii
004journal_volume
18pub_type
杂志文章abstract::Fibrodysplasia ossificans progressiva is a rare and disabling syndrome, which is characterized by heterotopic ossifications and skeletal deformities. So far, around 200 patients with fibrodysplasia ossificans progressiva have been reported in the world literature. Herein, we analyze the clinical records of 7 known cas...
journal_title:Archives of Iranian medicine
pub_type: 杂志文章,多中心研究
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更新日期:2013-03-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章,多中心研究
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更新日期:2017-06-01 00:00:00
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journal_title:Archives of Iranian medicine
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更新日期:2015-10-01 00:00:00
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更新日期:2007-04-01 00:00:00
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:2008-05-01 00:00:00
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journal_title:Archives of Iranian medicine
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更新日期:2018-12-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:010136/0014
更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
doi:0161911/AIM.0010
更新日期:2016-11-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2018-08-01 00:00:00
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journal_title:Archives of Iranian medicine
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doi:
更新日期:2020-03-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
doi:0161912/AIM.007
更新日期:2016-12-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:012157/AIM.0011
更新日期:2012-07-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:013169/AIM.0013
更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:08113/AIM.0010
更新日期:2008-05-01 00:00:00
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journal_title:Archives of Iranian medicine
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doi:
更新日期:2006-04-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0151805/AIM.006
更新日期:2015-05-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 历史文章,杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:
更新日期:2019-02-01 00:00:00
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journal_title:Archives of Iranian medicine
pub_type: 杂志文章
doi:0161908/AIM.0013
更新日期:2016-08-01 00:00:00