Abstract：
BACKGROUND:It is suggested that pregnancy-associated plasma protein-A (PAPP-A) levels below the fifth percentile or less than 0.4 multiples of the median (MoMs) during the first trimester are closely associated with higher risk for neonatal abnormalities. We assessed the value of PAPP-A within the first trimester for predicting pregnancy outcome. METHODS:In a historical cohort study, we assessed 8460 consecutive pregnant women recruited for chromosomal abnormalities screening within the first trimester at Fertility Infertility and Perinatology Research Center, in Ahvaz Jundishapur University of Medical Sciences between April 2014 and April 2015. The women were categorized into two groups: pregnant women with PAPP-A levels below 0.4 multiples of MOM (n = 237) and those with higher levels of PAPP-A (n = 237). RESULTS:The median value of MOM PAPP-A was 0.82 ± 0.78, with 237 women having MOM PAPP-A lower than 0.4. Compared to women with MOM PAPP-A higher than 0.4, those with lower MOM PAPP-A had higher mean age, lower gestational age and lower birth weight. The prevalence of small for gestational age (SGA) was higher in women with MOM PAPP-A <0.4 compared to others. According to the ROC curve analysis, MOM PAPP-A <0.4 had a high value for predicting SGA. Best cutoff value for MOM PAPP-A to predict SGA was shown to be 0.25, yielding a sensitivity of 84.7% and a specificity of 68.6. CONCLUSION:Measuring the serum level of MOM PAPP-A during the first trimester is a valuable marker for predicting adverse outcomes of pregnancy such as SGA.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Mohamad Jafari R,Masihi S,Barati M,Maraghi E,Sheibani S,Sheikhvatan Msubject
Has Abstractpub_date
2019-10-01 00:00:00pages
584-587issue
10eissn
1029-2977issn
1735-3947pii
S1029-2977-22(10)584-0journal_volume
22pub_type
杂志文章abstract：:Venous thromboembolism refers to thrombotic events in the venous system that are most commonly manifested as deep vein thromboses in the upper or lower extremity and/or pulmonary embolism. Venous thromboembolism is a common disorder that is associated with significant mortality, morbidity and health care-related cost....
journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：:Vitamin D is a pro-hormone that plays an important role in body calcium regulation. Vitamin D toxicity occurs rarely due to its wide therapeutic index. A 38-year-old Iranian man was admitted to our hospital with a diagnosis of vitamin D toxicity. Laboratory test revealed hypercalcemia and elevated 25-hydroxyvitamin D ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0161908/AIM.0013
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Cardiovascular disease (CVD) is among the most common causes of mortality in all populations. Nonalcoholic steatohepatitis is a common finding in patients with CVD. Prevention of CVD in individual patients typically requires periodic clinical evaluation, as well as diagnosis and management of risk factors su...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：015188/AIM.009
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:The childhood obesity epidemic is one of the most serious global health challenges, and many relevant policies have been designed and implemented. Regarding health equity policy-making, it is important to adopt proper interventional strategies, including childhood obesity policies. The purpose of this study ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-11-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：013169/AIM.003
更新日期：2013-09-01 00:00:00
abstract：:The history of early attempts of blood transfusion in Iran traces back to the 1940s; however, around three decades later in 1974, the Iranian National Blood Transfusion Service (Sazeman-e Melli-e Enteqal-e Khun-e Iran) was founded by the outstanding hematologist, Professor Fereydoun Ala. The main goals of this central...
journal_title：Archives of Iranian medicine
pub_type： 传,历史文章,杂志文章
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：10.34172/aim.2020.87
更新日期：2020-10-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：014176/AIM.0011
更新日期：2014-06-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：10.34172/aim.2020.74
更新日期：2020-09-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0131610/AIM.008
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to investigate the association between Trp719Arg (rs20455) and Coronary Heart Disease (CHD), and also Coronary Heart Disease reduction in individuals with this SNP during statin therapy in southern Iran. It has been shown that rs20455, which could affect the function of kinesin ...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151810/AIM.008
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Pancreatic cancer is the fourth most common cause of mortality due to cancer, globally. It has a poor prognosis and is usually diagnosed at later stages when tumor resection is not possible. Heritability for pancreatic cancer is relatively high and clinically significant. METHODS:A group of 24 pancreatic ca...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2018-06-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0151811/AIM.003
更新日期：2015-11-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2019-02-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:The Fas/Fas ligand (FasL) system has been recognized as an important pathway for apoptosis induction in cells and tissues. It has recently been shown that skin lesions of pemphigus vulgaris are associated with Fas mediated apoptosis. The aim of this study was to evaluate the level of serum soluble Fas of ten...
journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：011143/AIM.0011
更新日期：2011-05-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：012155/AIM.0011
更新日期：2012-05-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
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更新日期：2008-05-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：0161908/AIM.003
更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：10.34172/aim.2020.46
更新日期：2020-07-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0161904/AIM.006
更新日期：2016-04-01 00:00:00
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journal_title：Archives of Iranian medicine
pub_type： 杂志文章
doi：0131612/AIM.0012
更新日期：2013-12-01 00:00:00
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journal_title：Archives of Iranian medicine
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doi：010134/AIM.006
更新日期：2010-07-01 00:00:00
