Abstract:
BACKGROUND:Chorionic Villous Sampling (CVS) is a diagnostic method for determining genetic disorders. The present study aimed to determine the negative predictive value of the CVS in the diagnosis of major thalassemia in genetic laboratory of Dastgheib Hospital, Shiraz, Iran. METHODS:The present research was an evaluation diagnostic test conducted on 372 records of embryos examined through CVS in the genetic lab in 2010 and definitely diagnosed by electrophoresis after birth in 2012. The sensitivity and positive predictive value of the test were assessed for minor thalassemia. The negative predictive value and the specificity of this test were determined, as well. RESULTS:A total of 3 embryos (0.8%) were aborted due to testing. In this study, the sensitivity and specificity were 94.8% and 80.4%, respectively. Also, the negative predictive values for diagnosis of major and minor thalassemia were 100% and 89.2%, respectively. No relationships were found between the gestational age and the test results. CONCLUSION:The results of this study showed that CVS genetic testing in genetic laboratory of Dastgheib Hospital was valid and had a high diagnostic value. Thus, minor couples can undergo this test with relative safety in order to prevent major thalassemia.
journal_name
Arch Iran Medjournal_title
Archives of Iranian medicineauthors
Ghahramani F,Alimohamadi Y,Mahboubi M,Afrasiabi Adoi
0141707/AIM.007subject
Has Abstractpub_date
2014-07-01 00:00:00pages
483-5issue
7eissn
1029-2977issn
1735-3947pii
007journal_volume
17pub_type
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