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Two replication initiators - one mechanism for replication origin opening?

Abstract：

:DNA replication initiation has been well-characterized; however, studies in the past few years have shown that there are still important discoveries to be made. Recent publications concerning the bacterial DnaA protein have revealed how this replication initiator, via interaction with specific sequences within the origin region, causes local destabilization of double stranded DNA. Observations made in the context of this bacterial initiator have also been converging with those recently made for plasmid Rep proteins. In this mini review we discuss the relevance of new findings for the RK2 plasmid replication initiator, TrfA, with regard to new data on the structure of complexes formed by the chromosomal replication initiator DnaA. We discuss structure-function relationships of replication initiation proteins.

journal_name

Plasmid

journal_title

Plasmid

authors

Zabrocka E,Wegrzyn K,Konieczny I

doi

10.1016/j.plasmid.2014.10.003

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

72-8

eissn

0147-619X

issn

1095-9890

pii

S0147-619X(14)00078-X

journal_volume

76

pub_type

杂志文章,评审

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