Abstract：
INTRODUCTION:Thyroid hormone disorders in patients with chronic kidney disease (CKD) are a result of impaired conversion of T4 to T3. The importance of kidneys in thyroid hormones conversion is not fully understood. The activities of different types of iodothyronine deiodinases in the kidney structures have not been determined yet. The aim of this study was to determine the activity of deiodinase type 1 (D1) and type 2 (D2) in renal cortex and medulla in renal cancer patients. MATERIAL AND METHODS:Samples of renal cortex and medulla (ten patients) or renal cortex alone (13 patients) were taken from kidneys resected because of malignant cancer, from a site opposite to the cancer. Resections were performed in the 23 patients (seven female and 16 male) who were 52-82 years old. The material was stored at -72 oC. RESULTS:Activity of D1 in renal cortex was 3.785 ± 2.041 fmol 125I/mg protein/minute and activity of D2 was 0.236 ± 0.125 fmol 125I/mg protein/minute. There was a strong positive correlation between D1 and D2 activities in renal cortex (r = 0.890, p 〈 0.001). Activity of D1 in renal medulla was 2.157 ± 2.176 fmol 125I/mg protein/minute, and activity of D2 was 0.168 ± 0.095 fmol 125I/mg protein/minute. A positive correlation between D1 and D2 in renal medulla (r = 0.661, p = 0.038) was observed as well. Activities of D1 in cortex and medulla were strongly and positively associated (r = 0.794, p = 0.006), whereas there was no correlation between the activities of D2 in cortex and medulla (r = 0.224, p = 0.553). CONCLUSIONS:Results presented in this study suggest that both cortical and medullary D1 and D2 may be involved in thyroid hormone metabolism. This finding could be of clinical relevance in patients with impaired renal function.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Niemczyk S,Dudek M,Bartoszewicz Z,Szamotulska K,Woźniacki L,Brodowska-Kania D,Niemczyk L,Małek W,Matuszkiewicz-Rowińska Jsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
182-5issue
3eissn
0423-104Xissn
2299-8306journal_volume
64pub_type
杂志文章abstract：:Increased interest in vitamin D measurements in clinical studies has contributed to the development in recent years of several new immunochemical assays (manual and for automatic analyzers). New methods, including HPLC (high performance liquid chromatography), and LC-MS/MS (liquid chromatography coupled with tandem ma...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye. MATERIAL AND METHODS:30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulf...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0038
更新日期：2014-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-07-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2016.0061
更新日期：2016-01-01 00:00:00
abstract：:Anorexia nervosa is an eating disorder characterized by conscious restriction of food intake, which causes numerous metabolic and hormonal disorders. Knowledge of these changes is important due to growing morbidity and mortality of anorexia. Treatment is difficult and requires cooperation of a group of specialists, in...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2008-03-01 00:00:00
abstract：:We have recently observed an increased interest in gastro-entero-pancreatic neuroendocrine tumors (GEP NET). They are rare cancer types and therefore collaborative effort of specialists in various disciplines of medicine is necessary to work out the diagnostic and therapeutic guidelines. In this publication we present...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2018.0091
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0071
更新日期：2020-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0060
更新日期：2014-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0020
更新日期：2020-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2017.0053
更新日期：2017-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 历史文章,杂志文章
doi：
更新日期：2008-05-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/ep.2013.0001
更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2007-03-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0027
更新日期：2014-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,随机对照试验
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更新日期：2017-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
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journal_title：Endokrynologia Polska
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更新日期：2020-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Endokrynologia Polska
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更新日期：2019-01-01 00:00:00
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journal_title：Endokrynologia Polska
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doi：
更新日期：2011-01-01 00:00:00
