New classification of thyroid FNAB results - a three-year observation from one clinic.

Abstract:

INTRODUCTION:Fine needle aspiration biopsy (FNAB) is the main examination in diagnostics of thyroid nodules. Yet, it does not allow the differentiation of follicular lesions (FL). A new classification of thyroid biopsy results (newC) might improve pre-operative diagnostics mainly due to the introduction of a new subcategory of 'follicular lesion of undetermined significance', as well as the clarification of definitions of other categories. The aim of this study was to analyse the impact of the newC on the distribution of the cytological results among main diagnostic categories and on the values of the parameters describing the effectiveness of FNAB in detecting malignancy. MATERIAL AND METHODS:34,371 FNABs outcomes and 3,557 results of surgical follow up were analysed. The frequencies of five main diagnostic categories in two periods: before (years: 2000-2009, 24,271 FNAB) and after the newC had been introduced (years: 2010-2012, 10,100 FNAB) were compared, as well as parameters describing the biopsy effectiveness, with a special focus on FL. RESULTS:In the second analysed period, the frequency of the 'suspicious for malignancy' results was three times lower, while diagnoses of 'malignant neoplasm' were 33% more frequent and the results corresponding to FL decreased by 10%. In respect to FL, specificity of FNAB increased (22.6% vs. 57.4%), but sensitivity decreased (78.8% vs. 50.0%). In respect to other diagnostic categories considered jointly, the sensitivity of FNAB (61.2% vs. 85.7%) and PPV (57.4% vs. 77.8%) increased, and the specificity was similar (95-97%) for both periods. NPV exceeded 95% irrespective of applied classification. CONCLUSIONS:Separation of FL with low risk of malignancy affects the values of the parameters describing the effectiveness of FNAB. The improved diagnostic effectiveness of FNAB is also a consequence of epidemiological changes and better selection of thyroid lesions for biopsy.

journal_name

Endokrynol Pol

journal_title

Endokrynologia Polska

authors

Woźniak-Oseła E,Popowicz B,Sporny S,Klencki M,Słowińska-Klencka D

doi

10.5603/EP.2014.0060

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

431-7

issue

6

eissn

0423-104X

issn

2299-8306

pii

VM/OJS/J/38096

journal_volume

65

pub_type

杂志文章
  • [Family incidence of latent autoimmune diabetes in adults--case report].

    abstract::We describe a 37 year-old woman case of latent autoimmune diabetes in adults (LADA). She was presented with unfounded weight loss. The diagnosis of diabetes mellitus was established on twice plasma glucose measurements above 200 mg/dl. In other routine biochemical examinations we did not observe dehydratation, electro...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Szepietowska B,Szelachowska M,Górska M

    更新日期:2006-05-01 00:00:00

  • Vascular and cardiac function in young adults with classical congenital adrenal hyperplasia.

    abstract:INTRODUCTION:Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. MATERIAL AND METHODS:Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 year...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:10.5603/EP.a2017.0046

    authors: Wierzbicka-Chmiel J,Chmiel A,Rychlik S,Ogrodowczyk-Bobik M,Marek B,Kajdaniuk D

    更新日期:2017-01-01 00:00:00

  • Patient satisfaction and preferences of lanreotide Autogel treatment in acromegaly.

    abstract:INTRODUCTION:Despite the known importance of somatostatin analogues (SSAs) in the treatment of acromegaly, patient satisfaction leading to preferences for specific SSAs have received little attention so far. MATERIAL AND METHODS:This open, prospective, observational, multicentre patient-reported outcome study included...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,多中心研究

    doi:10.5603/EP.2016.0066

    authors: Witek P,Mucha S,Ruchała M

    更新日期:2016-01-01 00:00:00

  • Association between omentin-1, bone metabolism markers, and cytokines of the RANKL/RANK/OPG system in girls with anorexia nervosa.

    abstract:INTRODUCTION:Omentin-1, secreted by visceral adipose tissue, has been indicated in the regulation of bone metabolism in girls with anorexia nervosa (AN). The aim of the study was to evaluate the relationship between omentin-1 and bone metabolism in girls with AN as well as the potential involvement of OPG and RANKL in ...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:10.5603/EP.2015.0063

    authors: Gołąbek K,Ostrowska Z,Ziora K,Oświęcimska J,Świętochowska E,Marek B,Kajdaniuk D,Strzelczyk J,Kos-Kudła B

    更新日期:2015-01-01 00:00:00

  • Intake of iodine-containing multivitamin preparations by pregnant women from the Krakow region of Poland.

    abstract:BACKGROUND:The aim of this study was to evaluate the number of women who take multivitamin formulations containing iodine. MATERIAL AND METHODS:A 34-question questionnaire was given to 500 women during their puerperal stay in two obstetrics/gynaecology wards in Krakow. RESULTS:295 pregnant women (59%) took iodine-con...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Milewicz T,Czyżewicz M,Stochmal E,Galicka-Latała D,Hubalewska-Dydejczyk A,Krzysiek J

    更新日期:2011-01-01 00:00:00

  • A case of premature ovarian failure (POF) in a 31-year-old woman with a 47,XXX karyotype.

    abstract::A case of POF in a 31-year-old woman with karyotype 47,XXX. The aim of the study was to discuss a case of POF in a 31-year-old patient with polysomy 47,XXX. The described karyotype is not usually associated with this characteristic physical phenotype. In some rare cases, menstrual disorders, sterility, secondary ameno...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Skałba P,Cygal A,Gierzyńska Z

    更新日期:2010-03-01 00:00:00

  • Sonographic assessment of congenitally hypothyroid children in Iran.

    abstract:INTRODUCTION:Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, it seems that it is necessary to investigate the aetiology of the disorder and its related factors. The aim of this study was to determine the aetiology of CH among children in Isfahan province. MATERIAL AND METHODS:In this cros...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Hoseini M,Hekmatnia A,Hashemipour M,Basiratnia R,Omidifar N,Rezazade A,Koohi R

    更新日期:2010-11-01 00:00:00

  • Successful EUS-guided ethanol ablation of insulinoma, four-year follow-up. Case report and literature review.

    abstract:INTRODUCTION:EUS-guided ethanol ablation of insulinoma is a new method of treatment of this neuroendocrine tumour. Ablation is recommended in patients who are poor surgical candidates or refuse surgery. We present a case of an 81-year-old female with symptomatic insulinoma, treated successfully with EUS-guided alcoholi...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:10.5603/EP.2017.0053

    authors: Dąbkowski K,Gajewska P,Walter K,Londzin-Olesik M,Białek A,Andrysiak-Mammos E,Kos-Kudła B,Starzyńska T

    更新日期:2017-01-01 00:00:00

  • [Anorexia nervosa].

    abstract::Anorexia nervosa is an eating disorder characterized by conscious restriction of food intake, which causes numerous metabolic and hormonal disorders. Knowledge of these changes is important due to growing morbidity and mortality of anorexia. Treatment is difficult and requires cooperation of a group of specialists, in...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:

    authors: Nogal P,Lewiński A

    更新日期:2008-03-01 00:00:00

  • Adrenal-sparing surgery for a hormonally active tumour - a single-centre experience.

    abstract:INTRODUCTION:Surgeries that spare the adrenal cortex during adrenalectomy have profound justification. Indications for this type of surgery are fairly strict, and more than 30 years of observations continuously verify the results of the procedure. MATERIAL AND METHODS:Of a total of 650 adrenalectomies, 22 (3.4%) were ...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:10.5603/EP.a2020.0033

    authors: Toutounchi S,Pogorzelski R,Wołoszko T,Krajewska E,Celejewski K,Legocka M,Jakuczun W,Gałązka Z

    更新日期:2020-01-01 00:00:00

  • [A case associating primary parathyroid hyperfunction with hyperthyroidism].

    abstract::A case of rare association of hyperparathyroidism with fully developed hyperthyroidism appearing in a woman 23 years old with advanced generalized cystic fibrosis has been presented. ...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Plamieniak Z,Głebowska-Halawa H,Bednorz W,Komorski A

    更新日期:1992-01-01 00:00:00

  • [Thyroid hormones and the cardiomyocytes].

    abstract::The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:

    authors: Gatnar A,Marek B,Pakuła D,Kajdaniuk D,Kos-Kudła B,Borgiel-Marek H,Gnot R,Pakuła P,Pawłowska M

    更新日期:2006-03-01 00:00:00

  • [Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism].

    abstract:INTRODUCTION:The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism. MATERIAL AND METHODS:The study was conduc...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Rybus-Kalinowska B,Zwirska-Korczala K,Kalinowski M,Kukla M,Birkner E,Jochem J

    更新日期:2009-05-01 00:00:00

  • The polycystic ovary syndrome: a position statement from the Polish Society of Endocrinology, the Polish Society of Gynaecologists and Obstetricians, and the Polish Society of Gynaecological Endocrinology.

    abstract::Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the ...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,实务指引

    doi:10.5603/EP.2018.0046

    authors: Milewicz A,Kudła M,Spaczyński RZ,Dębski R,Męczekalski B,Wielgoś M,Ruchała M,Małecka-Tendera E,Kos-Kudła B,Jędrzejuk D,Zachurzok A

    更新日期:2018-01-01 00:00:00

  • Primary aldosteronism - recent progress and current concepts.

    abstract::Primary aldosteronism is the commonest form of hormone-related hypertension, with an estimated prevalence of 6-13% in the generalpopulation of hypertensive patients. Among patients with resistant hypertension, the proportion of PA is even higher. Through intensiveresearch in the field of basic science and the creation...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:10.5603/ep.2013.0011

    authors: Kołodziejczyk-Kruk S,Januszewicz W,Pęczkowska M,Prejbisz A,Zgliczyński W,Januszewicz A

    更新日期:2013-01-01 00:00:00

  • Effect of testosterone replacement therapy on vitamin D and FGF-23 levels in congenital hypogonadism.

    abstract:INTRODUCTION:Patients with hypogonadism are at increased risk of cardiac and metabolic diseases and osteoporosis. Vitamin D and Fibroblast growth factor-23 (FGF-23) play role in the regulation of bone mineral metabolism and endothelial functions. Low vitamin D levels are reported in hypogonadism, while there is no data...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:10.5603/EP.a2017.0009

    authors: Haymana C,Sonmez A,Aydogdu A,Tapan S,Basaran Y,Meric C,Baskoy K,Taslipinar A,Yilmaz MI,Azal O

    更新日期:2017-01-01 00:00:00

  • The management of Cushing's disease - from investigation to treatment.

    abstract::Cushing's disease (CD) is caused by an adrenocorticotrophin (ACTH) secreting pituitary adenoma and it is the commonest cause of endogenous hypercortisolism. When high suspicion of Cushing's syndrome (CS) exists, recommended screening tests include the overnight dexamethasone suppression test, the low-dose dexamethason...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:

    authors: Juszczak A,Grossman A

    更新日期:2013-01-01 00:00:00

  • Clinical implications of GWAS variants associated with differentiated thyroid cancer.

    abstract::The genetic risk of differentiated thyroid cancer (DTC) probably consists of multiple low-penetrance, single-nucleotide polymorphisms (SNP). Such markers are difficult to uncover by linkage analysis but can be revealed by association studies. Genome-wide association studies (GWASs) have uncovered 31 SNPs associated wi...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:10.5603/EP.a2019.0027

    authors: Jendrzejewski JP,Sworczak K,Comiskey DF,de la Chapelle A

    更新日期:2019-01-01 00:00:00

  • [Acromegaly--from myths to facts].

    abstract::The authors present numerous historical descriptions of persons who might suffered from gigantism or acromegaly. The oldest medical data of patients, initial attempts of causal neurosurgical treatment, history of growth hormone, insulin-like growth factor-1, growth hormone releasing hormone and somatostatin discovery ...

    journal_title:Endokrynologia Polska

    pub_type: 历史文章,杂志文章

    doi:

    authors: Kałuzny M,Bolanowski M

    更新日期:2008-05-01 00:00:00

  • Endocrine complications of cancer immunotherapy.

    abstract::Immunotherapy using monoclonal antibodies - checkpoint inhibitors - is a dynamically evolving discipline of clinical oncology and a new hope for patients with advanced and disseminated cancer. However, the activation of T-lymphocytes can at the same time lead to autoimmune response and destruction of healthy organs, w...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:10.5603/EP.a2018.0073

    authors: Król A,Gawlik T,Jarząb B

    更新日期:2018-01-01 00:00:00

  • Chronic noise exposure and testosterone deficiency -- meta-analysis and meta-regression of experimental studies in rodents.

    abstract:INTRODUCTION:Chronic psychological distress can cause suppression of the hypothalamic-pituitary-testicular axis and thus lead to male hypogonadism, which is associated with psycho-social dysfunction, chronic diseases, and as a result, considerable economic costs. Conversely, noise is a prototypal environmental stressor...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,meta分析,评审

    doi:10.5603/EP.2015.0007

    authors: Dzhambov A,Dimitrova D

    更新日期:2015-01-01 00:00:00

  • [Occurrence of androgen receptor gene CAG trinucleotide sequence polymorphism in the metropolitan population of Polish men].

    abstract:BACKGROUND:The activity of androgen receptor (AR) is modulated by a polymorphic region located within exon 1 its gene and characterizing a variable number of trinucleotide CAG repeats. The length of polymorphic region is inversely correlated with the transactivation function of AR gene. It was showed an ethnic differen...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Filus A,Medraś M,Kuliczkowska-Płaksej J,Trzmiel-Bira A,Laczmański L,Jedrzejuk D

    更新日期:2009-07-01 00:00:00

  • Bone status in adolescents and young adults with type 1 diabetes: a 10-year longitudinal study.

    abstract:INTRODUCTION:This study presents a 10-year longitudinal assessment of bone status in adolescents and young adults with type 1 diabetes (T1D). MATERIAL AND METHODS:Thirty-two patients (12 female, aged 20.5 ± 3.93 years, T1D duration 13.9 ± 1.97 years) were studied using quantitative ultrasound (QUS) and dual-energy X-r...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:10.5603/EP.a2020.0080

    authors: Chobot A,Janota O,Bąk-Drabik K,Polanska J,Pluskiewicz W

    更新日期:2020-01-01 00:00:00

  • The role of i.v. ibandronate administration in osteoporosis therapy.

    abstract::Osteoporosis is a chronic disease of the osseous system characterised by decreased strength of bone tissue, which in turn leads to increased fracture risk. It has been demonstrated that osteoporosis affects more than 30% of women after the menopause (WHO, 1994). However, the disease is also observed in men. The primar...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:

    authors: Sewerynek E,Stuss M

    更新日期:2011-01-01 00:00:00

  • Surgical approach to differentiated thyroid cancers (DTC) in children [Specyfika leczenia chirurgicznego zróżnicowanych raków tarczycy (ZRT) u dzieci].

    abstract::Thyroid cancer in children is rare and accounts for 1-3% of all malignant tumours. Differentiated thyroid cancers (DTC) and particularly papillary thyroid carcinoma (PTC) (90% of cases) are the most prevalent. Surgery is the mainstay of treatment in patients with DTC. The current recommendations are based not on prosp...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:10.5603/EP.a2019.0033

    authors: Czarniecka A,Woźniak G,Kropińska A,Jarząb B,Handkiewicz-Junak D

    更新日期:2019-01-01 00:00:00

  • Changes of systemic microinflammation after weight loss and regain - a five-year follow up study.

    abstract:INTRODUCTION:The aim of this study was to evaluate the influence of body mass changes on plasma concentrations of proinflammatory cytokines in obese women after the initially obtained weight reduction in a five-year follow-up period. MATERIAL AND METHODS:Thirty out of 42 women with simple obesity (age 41.8 ± 11.9 year...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Olszanecka-Glinianowicz M,Chudek J,Szromek A,Zahorska-Markiewicz B

    更新日期:2012-01-01 00:00:00

  • [Effect of naloxone on beta-endorphin and insulin concentrations during glucose tolerance testing in patients with simple obesity].

    abstract::The concentrations of beta-endorphin, ACTH, insulin (IRI), glucagon (IRG), cortisol and growth hormone were determined by radioimmunoassay during oral glucose tolerance test (OGTT) performed in 13 obese patients with normal glucose tolerance and without arterial hypertension. The test was performed in random, before a...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:

    authors: Krzyzanowska-Swiniarska B,Gruszczyńska M,Pilarska K,Widecka K,Czekalski S

    更新日期:1993-01-01 00:00:00

  • Primary aldosteronism: a common and important problem. A practical guide to the diagnosis and treatment.

    abstract::In view of the fact that primary aldosteronism (PA) is a problem that is more prevalent than previously thought and its diagnosis is of greater clinical significance than previously believed, the Endocrine Society has recently published recommendations on the diagnosis and management of PA. Due to the fact that the cu...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章,评审

    doi:

    authors: Myśliwiec J,Górska M

    更新日期:2012-01-01 00:00:00

  • Peripheral levels of selected adipokines in patients with newly diagnosed multiple sclerosis.

    abstract:INTRODUCTION:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The exact aetiology is unknown. However, genetic and environmental factors are suggested to be involved in the pathogenesis of MS. Improper diet, resulting in obesity and metabolic syndrome, can contribute to this disease. Adip...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:10.5603/EP.a2020.0008

    authors: Baranowska-Bik A,Uchman D,Litwiniuk A,Kalisz M,Martyńska L,Baranowska B,Bik W,Kochanowski J

    更新日期:2020-01-01 00:00:00

  • Genetic testing of PAX8 mutations associated with thyroid dysgenesis in Chinese congenital hypothyroidism patients.

    abstract:INTRODUCTION:Thyroid dysgenesis (TD) is the main cause of congenital hypothyroidism (CH), affecting nearly 1 in 2000-3000 newborns worldwide, as the most common neonatal endocrine disorder. Paired box gene 8 (PAX8), expressed during all stages of thyroid follicular cell, plays a key role in thyroid morphogenesis by a c...

    journal_title:Endokrynologia Polska

    pub_type: 杂志文章

    doi:10.5603/EP.a2020.0004

    authors: Li M,Wang F,Wang X,Zang Y,Liu W,Wang F,Zhang L,Tang Q,Liu S,Zhao D

    更新日期:2020-01-01 00:00:00