Abstract：
:Osteoporosis is a chronic disease of the osseous system characterised by decreased strength of bone tissue, which in turn leads to increased fracture risk. It has been demonstrated that osteoporosis affects more than 30% of women after the menopause (WHO, 1994). However, the disease is also observed in men. The primary goals of osteoporosis therapy include prevention of low-energy fractures and general improvement of quality of life. Any patient with diagnosed osteoporosis requires, besides prevention, the application of proper treatment. Of the available therapeutic options, the best are bisphosphonates, medical agents with well identified properties, therapeutic efficacy, and safety which has been confirmed in many clinical studies. Therefore, they are recommended as first line drugs for osteoporosis. The efficacy of oral preparations may be limited, due to low bioavailability, complications and adverse effects from the gastrointestinal tract. So the parenteral administration of bisphosphonates is a valuable alternative. A fine example of such therapy is the intravenous administration of ibandronate. Short injection time periods and the relatively long, three-month intervals between administrations are unquestionable advantages of this therapy mode. In addition, the therapy does not constrain a patient's everyday activity, and simultaneously provides regular contact with doctors and the therapeutic centre. Additionally, a good tolerance of the drug and its high therapeutic efficacy, proven by appreciably reduced fracture risks, significantly improves the quality of life of patients suffering from osteoporosis. This paper is a thorough review of current knowledge on the efficacy and safety of i.v. ibandronate in osteoporosis therapy, as presented in the latest literature reports.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Sewerynek E,Stuss Msubject
Has Abstractpub_date
2011-01-01 00:00:00pages
51-60issue
1eissn
0423-104Xissn
2299-8306journal_volume
62pub_type
杂志文章,评审abstract：:According to the socio-sexological reports approximately 40-45% of women and up to 30% of males may suffer from different sexual dysfunctions. The prevalence of those disorders is gradually increasing with age. Multiply numbers of endocrinopathies may influence the human sexual life. In diabetic patients all phases of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-11-01 00:00:00
abstract：INTRODUCTION:In order to be effective, treatment for osteoporosis must be long-term. Unfortunately, according to clinical trials and clinical practice the most frequent cause of patient resignation from the treatment is adverse reactions to the medications. In the case of bisphosphonates they are most frequently connec...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI¹³¹ treatment for hyperthyroidism and to report the index cases' characteristics and management MATERIAL AND METHODS: A cohort of 264 patients who received RAI¹³¹ treatment for different causes of thyrotoxicosis...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.a2017.0037
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The present study aims to evaluate the incidence, types, timing and risk factors in amiodarone (AMD)-induced thyroid dysfunction. MATERIAL AND METHODS:The study comprised 229 patients from an iodine-replete area (115 women, 114 men, mean age 63.8 ± 9.2 years), chronically treated with AMD. The cases were ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:We evaluated the predictive value of IGF-1 against hGH in the treatment outcome. MATERIAL AND METHODS:A prospective study was undertaken of 47 patients (mean age 41.1 ± 12.9 years; 44 with macroadenoma and 3 with microadenoma), requiring treatment with octreotide LAR (SSLAR) following incomplete surgery. Co...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content. MATERIAL AND METHODS:We studied two age-, we...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0013
更新日期：2019-01-01 00:00:00
abstract：:The study was aimed at the assessment of frequency of occurrence of thyroid antimicrosomal and antithyreoglobuln autoantibodies in children with insulin-dependent diabetes and healthy control children. The occurrence of thyroid autoantibodies was analyzed with respect to the age and sex of children and the duration of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves' hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive f...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：INTRODUCTION:The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism. MATERIAL AND METHODS:The study was conduc...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：:Endocrinological Out-Patients Clinic at Children's Hospital in Dziekanów Leśny takes care of the children from Mazovia region. Hormonal findings in children with simple goiter were analyzed in several groups of patients. In all those patients preferential T3-secretion and decreased T4 production was found. These findi...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：INTRODUCTION:In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye. MATERIAL AND METHODS:30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulf...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0038
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:Symptoms of precocious puberty (PP) in children always arouse anxiety in their parents. Many children with PP are being hospitalized for the detailed diagnostic work-up. The aim of our study was to analyze the frequency of the variants of PP in children referred to our department. MATERIAL:Retrospective a...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：:Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Cushing's disease (CD) is caused by an adrenocorticotrophin (ACTH) secreting pituitary adenoma and it is the commonest cause of endogenous hypercortisolism. When high suspicion of Cushing's syndrome (CS) exists, recommended screening tests include the overnight dexamethasone suppression test, the low-dose dexamethason...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：:Diabetic kidney disease (DKD) remains the leading cause of the end-stage renal disease (ESRD) and the most common reason for renal replacement therapy. Research has been carried out for years to find a marker that would enable early identification of people at risk of DKD occurrence, as well as people who will progres...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0077
更新日期：2020-01-01 00:00:00
abstract：:Ig-G4 related disease (IgG4RD) is a heterogeneous disorder with multi-organ involvement recognised as a separate entity at the start of this century only. It is currently one of the hottest areas of clinical and translational research across specialties. Thyroid involvement in IgG4RD is rare, believed to occur in less...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2016.0061
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:papillary thyroid microcarcinoma is a well-known malignant neoplasm with good prognosis. The known prognostic factors are patient's age, multifocality, and extrathyroidal extension. CD9 and CD82, members of the tetraspanin family, are expressed in numerous cancer cells and play many roles associated with t...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0009
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate the influence of body mass changes on plasma concentrations of proinflammatory cytokines in obese women after the initially obtained weight reduction in a five-year follow-up period. MATERIAL AND METHODS:Thirty out of 42 women with simple obesity (age 41.8 ± 11.9 year...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Increased interest in vitamin D measurements in clinical studies has contributed to the development in recent years of several new immunochemical assays (manual and for automatic analyzers). New methods, including HPLC (high performance liquid chromatography), and LC-MS/MS (liquid chromatography coupled with tandem ma...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Despite the known importance of somatostatin analogues (SSAs) in the treatment of acromegaly, patient satisfaction leading to preferences for specific SSAs have received little attention so far. MATERIAL AND METHODS:This open, prospective, observational, multicentre patient-reported outcome study included...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,多中心研究
doi：10.5603/EP.2016.0066
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:After thyroidectomy and radioiodine therapy, patients with differentiated thyroid cancer (DTC) are indefinitely treated with levothyroxine (L-T4). Osteoporosis is a debated consequence of hypothyroxinaemia. The aim of this study was to evaluate bone mineral density (BMD) and fracture risk assessed by FRAX ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2016.0046
更新日期：2016-01-01 00:00:00
abstract：:Epidemiological foundation included: aim of studies, knowledge about epidemiology of thyroid disorders in Poland, evaluation of radioiodine dose accumulated in thyroids of inhabitants of different age living in different par of Poland, information about relative diet iodine deficiency in different parts of Poland and ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:Surgery remains the most effective treatment for primary hyperparathyroidism (PHPT). Minimally invasive radioguided parathyroidectomy (MIRP) is a common technique for detecting and excising abnormal parathyroid glands. The aim of this study was to compare injections of low-dose and high-dose (99m) Tc metho...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0031
更新日期：2017-01-01 00:00:00
abstract：:Numerous members of semaphorins have been widely clarified to be involved in the development of multiple cancers. However, the semaphorin 6B (SEMA6B) has not yet been extensively reported in cancers, especially in thyroid carcinoma. According to the public dataset from TCGA database, we found that the expression of SE...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0072
更新日期：2020-10-30 00:00:00
abstract：:The introduction of sonographic imaging has revolutionized the diagnostics of thyroid pathologies. Nowadays, thyroid ultrasound examination has become an essential part of routine thyroid gland evaluation. Although one of the greatest advantages of this examination lies in its simplicity, it requires a solid theoretic...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with adipose tissue mass. Leptin was first described as acting on the satiety centre in the hypothalamus through specific receptors (ob-R) to restrict food intake and enhance energy expenditure. Leptin plays a crucial role in th...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:Bone disorders observed commonly after haematopoietic stem cells transplantation (HSCT) can be caused by several factors,but their detailed pathomechanism is still not well known, especially in childhood.The aim of this study was to evaluate: IGF-I, RANKL-OPG system, IL-6, and IL1β levels and their associa...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/ep.2013.0001
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0042
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Patients with Addison's disease experience many somatic and psychic changes, which decrease their quality of life. The aim of the study was to evaluate the "psychological equipment" of these patients to cope with stress connected with this chronic disease and the challenge of constant treatment. MATERIAL ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Neuroendocrine neoplasms of the large intestine account for 20% of all neuroendocrine neoplasms (NENs) and are most commonly found in the rectum. The rate of detection of colorectal NENs is increasing, and this tendency will continue due to the widespread use of colonoscopy as a screening tool and the removal of all d...
journal_title：Endokrynologia Polska
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.5603/EP.2013.0032
更新日期：2013-01-01 00:00:00
