Abstract：
:Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case of successfully treated acromegaly caused by ectopic GHRH secretion by bronchial neuroendocrine tumor and the usefulness of chromogranin A assay in the disease monitoring. The diagnosis of acromegaly in 61-year old woman was based on typical clinical picture and elevated GH and IGF-1(insulin-like growth factor-1) levels. MRI (magnetic resonance imaging) images revealed no tumor in the pituitary but only the pituitary enlargement. Moreover, the right lung tumor (10 cm size) and elevated GHRH level were documented. The secretion of GH, IGF-1 and GHRH were normalized and progression of acromegaly was stopped after the carcinoid tumor surgery. Currently, 5 year after surgery, acromegaly is still in the remission, as the normal levels of GH, IGF-1, chromogranin A and normal chest and pituitary images confirm. The authors emphasize usefulness of measurement of chromogranin A concentration for the evaluation of the tumor remission in case the routine GHRH assay is not accessible.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Bolanowski M,Kos-Kudła B,Rzeszutko M,Marciniak M,Zatońska Kkeywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
32-6issue
1eissn
0423-104Xissn
2299-8306journal_volume
57pub_type
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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doi：
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pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
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journal_title：Endokrynologia Polska
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更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
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更新日期：2011-01-01 00:00:00
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更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
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journal_title：Endokrynologia Polska
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更新日期：2011-01-01 00:00:00
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更新日期：2008-03-01 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
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