Abstract：
:Cushing's disease (CD) is caused by an adrenocorticotrophin (ACTH) secreting pituitary adenoma and it is the commonest cause of endogenous hypercortisolism. When high suspicion of Cushing's syndrome (CS) exists, recommended screening tests include the overnight dexamethasone suppression test, the low-dose dexamethasone suppression test, or late night salivary cortisol. If the initial test is positive on two occasions, the patient should be referred to a specialist endocrinologist for in-patient assessment, while elevated midnight serum cortisol and a low dose dexamethasone suppression test will confirm endogenous hypercortisolaemia. Plasma ACTH measurement at 9 am follows and, if elevated, MRI scan of the pituitary should be performed. Corticotrophin releasing hormone (CRH) test helps to distinguish pituitary from ectopic ACTH-dependent CS, though bilateral petrosal sinus sampling remains the gold standard. Transsphenoidal surgery is the recognised first-line treatment of CD, and can be repeated if unsuccessful. Second line therapy includes pituitary radiotherapy, bilateral adrenalectomy and medical treatment. Pituitary radiotherapy is very effective but it usually takes several years for its full effect to be seen. Bilateral adrenalectomy is useful in acutely unwell patients, who are unable to tolerate medical therapy. The most effective medical agents inhibit adrenal steroidogenesis and include metyrapone, ketoconazole, mitotane and etomidate. They are used in preparation for surgery, when an operation has been unsuccessful, or when the effects of radiotherapy are being awaited. Cabergoline and pasireotide decrease ACTH production, but are effective in only 30% and 25% of patients, respectively. It is crucial for patients with CD to be managed in specialist endocrine centres, as the expertise of multidisciplinary team members predicts the best outcome.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Juszczak A,Grossman Asubject
Has Abstractpub_date
2013-01-01 00:00:00pages
166-74issue
2eissn
0423-104Xissn
2299-8306journal_volume
64pub_type
杂志文章,评审abstract：:Many mechanism may participate in the inhibition of thyroid function by excess of iodine. The present study was aimed at answering the question, whether the excess of iodine influences the activity of type I thyroxine 5'-deiodinase. To 40 female rats fed with standard diet a dose of 42 micrograms of iodine daily was a...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:A case of rare association of hyperparathyroidism with fully developed hyperthyroidism appearing in a woman 23 years old with advanced generalized cystic fibrosis has been presented. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Renalase is a recently identified flavoprotein oxidase, secreted mainly by the kidneys, which takes part in the degradation of catecholamines. The catecholamine inactivating effect results in the modulation of the sympathetic system tension and, consequently, in a decrease of blood pressure, myocardial contractility, ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0044
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism. MATERIAL AND METHODS:The study was conduc...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
abstract：:Not required for Clinical Vignette. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0045
更新日期：2020-01-01 00:00:00
abstract：:The study, supported by program MZ-XVII, was carried on 4567 inhabitants of the area of Szczecin (2350 females and 2217 males). The population was chosen randomly, according to a simple drawing scheme. All subjects were clinically examined using standardised questionnaires. In 3468 persons (including 1807 girls and wo...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:Secondary hyperparathyroidism (sHPT) is one of the most common abnormalities found in patients with chronic kidney disease (CKD). Measurement of serum PTH concentrations is crucial in diagnosis and treatment of sHPT. Different methods of serum PTH measurement may provide diverse results. This may have a si...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0028
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. MATERIAL AND METHODS:Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 year...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0046
更新日期：2017-01-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,实务指引
doi：10.5603/EP.2018.0046
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Surgeries that spare the adrenal cortex during adrenalectomy have profound justification. Indications for this type of surgery are fairly strict, and more than 30 years of observations continuously verify the results of the procedure. MATERIAL AND METHODS:Of a total of 650 adrenalectomies, 22 (3.4%) were ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0033
更新日期：2020-01-01 00:00:00
abstract：:The present study is aimed to present the potential role of thyroid hormones (TH) in the pathogenesis of glioblastoma multiforme (GBM). In first part of this presentation the effect of general homeostasis of TH on GBM formation and course was shown. Then the evidence concerning present state of the knowledge about act...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2015.0055
更新日期：2015-01-01 00:00:00
abstract：:According to the socio-sexological reports approximately 40-45% of women and up to 30% of males may suffer from different sexual dysfunctions. The prevalence of those disorders is gradually increasing with age. Multiply numbers of endocrinopathies may influence the human sexual life. In diabetic patients all phases of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-11-01 00:00:00
abstract：:Obesity and thyroid function are closely related. Thyroid hormones are involved in the regulation of metabolism, thermogenesis, food intake, and fat oxidation. In obese children the most frequent hormonal abnormalities are slight hyperthyrotropinaemia and moderate increases in total T3 and/or fT3 concentrations. Those...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2017.0007
更新日期：2017-01-01 00:00:00
abstract：:The study was aimed at the assessment of frequency of occurrence of thyroid antimicrosomal and antithyreoglobuln autoantibodies in children with insulin-dependent diabetes and healthy control children. The occurrence of thyroid autoantibodies was analyzed with respect to the age and sex of children and the duration of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:After thyroidectomy and radioiodine therapy, patients with differentiated thyroid cancer (DTC) are indefinitely treated with levothyroxine (L-T4). Osteoporosis is a debated consequence of hypothyroxinaemia. The aim of this study was to evaluate bone mineral density (BMD) and fracture risk assessed by FRAX ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2016.0046
更新日期：2016-01-01 00:00:00
abstract：:Hypoxia-inducible factors (HIFs), as a family of transcription factors involved in the cellular response to hypoxia, are key regulatory factors in the regulation mechanism of an organism's response to hypoxia. A large number of studies have shown that HIFs are closely related to the angiogenesis, erythropoiesis, cell ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0064
更新日期：2020-01-01 00:00:00
abstract：:Epidemiological foundation included: aim of studies, knowledge about epidemiology of thyroid disorders in Poland, evaluation of radioiodine dose accumulated in thyroids of inhabitants of different age living in different par of Poland, information about relative diet iodine deficiency in different parts of Poland and ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0042
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye. MATERIAL AND METHODS:30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulf...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0038
更新日期：2014-01-01 00:00:00
abstract：:The aim of immunohistochemistry and immunocytochemistry is to reveal specific antigens in cells and tissue samples. Those techniques are based on an antigen-antibody reaction and visualization of its product in microscopic examination. The precursor of this new diagnostic procedure was an immunofluorescent reaction in...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-05-01 00:00:00
abstract：INTRODUCTION:Hypolipidaemic agents were found to affect plasma adipokine levels, but no previous study has investigated whether this effect is sex-dependent. MATERIAL AND METHODS:We retrospectively analysed 61 patients participating in our previous studies, who because of isolated hypercholesterolaemia were treated wi...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0017
更新日期：2015-01-01 00:00:00
abstract：:Numerous members of semaphorins have been widely clarified to be involved in the development of multiple cancers. However, the semaphorin 6B (SEMA6B) has not yet been extensively reported in cancers, especially in thyroid carcinoma. According to the public dataset from TCGA database, we found that the expression of SE...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0072
更新日期：2020-10-30 00:00:00
abstract：INTRODUCTION:Omentin-1, secreted by visceral adipose tissue, has been indicated in the regulation of bone metabolism in girls with anorexia nervosa (AN). The aim of the study was to evaluate the relationship between omentin-1 and bone metabolism in girls with AN as well as the potential involvement of OPG and RANKL in ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0063
更新日期：2015-01-01 00:00:00
abstract：:The concentrations of beta-endorphin, ACTH, insulin (IRI), glucagon (IRG), cortisol and growth hormone were determined by radioimmunoassay during oral glucose tolerance test (OGTT) performed in 13 obese patients with normal glucose tolerance and without arterial hypertension. The test was performed in random, before a...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:We have recently observed an increased interest in gastro-entero-pancreatic neuroendocrine tumors (GEP NET). They are rare cancer types and therefore collaborative effort of specialists in various disciplines of medicine is necessary to work out the diagnostic and therapeutic guidelines. In this publication we present...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:Surgery remains the most effective treatment for primary hyperparathyroidism (PHPT). Minimally invasive radioguided parathyroidectomy (MIRP) is a common technique for detecting and excising abnormal parathyroid glands. The aim of this study was to compare injections of low-dose and high-dose (99m) Tc metho...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0031
更新日期：2017-01-01 00:00:00
abstract：:Not required for Clinical Vignette. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0019
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:The introduction of the DICOM format in all diagnostic imaging devices allowed co-registering SPECT, CT, MR and other types of biomedical imaging. Fusion can be performed by dedicated hybrid devices or by means of software. The fusion algorithm consists of two steps: coregistration and simultaneous visuali...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:The introduction of sonographic imaging has revolutionized the diagnostics of thyroid pathologies. Nowadays, thyroid ultrasound examination has become an essential part of routine thyroid gland evaluation. Although one of the greatest advantages of this examination lies in its simplicity, it requires a solid theoretic...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:The basic data on hyperprolactinemia (i.e. an excess of PRL above a reference laboratory's upper limits), the most common endocrine disorder of the hypothalamic-pituitary axis are given in this review. The following issues are discussed: regulation of prolactin (Prl) secretion, definition of hyperprolactinemia, its et...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-01 00:00:00
