Abstract：
INTRODUCTION:Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator of glucose metabolism in mice. Moreover, OC level is decreased in patients with type 2 diabetes (T2D). Although inversely correlated with serum glucose insulin and glycated haemoglobin, it is unclear whether OC reduction is caused by diabetes or plays a role in the pathogenesis and/or progression of the disease. In this study we analysed the association between TaqI and ApaI VDR gene polymorphisms and OC serum concentration in T2D subjects. MATERIAL AND METHODS:Patients underwent clinical and nutritional assessment. Genomic DNA was extracted from leucocytes using a standard salting-out procedure. The polymorphisms were genotyped by PCR-RFLP method. ELISA was used to measure OC and insulin concentrations. RESULTS:Association between TT genotype of TaqI polymorphism and low levels of OC was observed only in the population with overweight and obesity. No association between TaqI and ApaI polymorphisms and T2D was observed (p > 0.05). Furthermore, in T2D subjects, no correlation between ApaI and TaqI genotypes and age, sex, Body Mass Index (BMI), glucose, or OC was observed. CONCLUSIONS:The TT genotype of TaqI VDR gene polymorphism was correlated with low levels of OC in overweight and obese subjects. However, TaqI and ApaI VDR gene polymorphisms were not associated with T2D.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Rivera-Leon EA,Palmeros-Sanchez B,Llamas-Covarrubias IM,Fernandez S,Armendariz-Borunda J,Gonzalez-Hita M,Bastidas-Ramirez BE,Zepeda-Moreno A,Sanchez-Enriquez Sdoi
10.5603/EP.2015.0042subject
Has Abstractpub_date
2015-01-01 00:00:00pages
329-33issue
4eissn
0423-104Xissn
2299-8306pii
VM/OJS/J/39721journal_volume
66pub_type
杂志文章abstract：BACKGROUND:We evaluated the predictive value of IGF-1 against hGH in the treatment outcome. MATERIAL AND METHODS:A prospective study was undertaken of 47 patients (mean age 41.1 ± 12.9 years; 44 with macroadenoma and 3 with microadenoma), requiring treatment with octreotide LAR (SSLAR) following incomplete surgery. Co...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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更新日期：1988-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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更新日期：2009-11-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0009
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,实务指引
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-01 00:00:00
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journal_title：Endokrynologia Polska
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doi：
更新日期：2012-01-01 00:00:00
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journal_title：Endokrynologia Polska
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更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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doi：
更新日期：1991-01-01 00:00:00
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journal_title：Endokrynologia Polska
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更新日期：2007-11-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Endokrynologia Polska
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doi：
更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
