Abstract：
BACKGROUND:We evaluated the predictive value of IGF-1 against hGH in the treatment outcome. MATERIAL AND METHODS:A prospective study was undertaken of 47 patients (mean age 41.1 ± 12.9 years; 44 with macroadenoma and 3 with microadenoma), requiring treatment with octreotide LAR (SSLAR) following incomplete surgery. Concentrations of hGH and IGF-1 were measured three months after surgery and three, six, nine, 12, 18, and 24 months after introducing SSLAR. RESULTS:Following surgery, respective median values of hGH and IGF-1 concentrations were 5.55 ng/mL (IQR = 7.1) and 512.7 ng/mL (IQR = 379.5). After six, 12, and 24 months of SSLAR treatment, median values of hGH decreased significantly: to 2.95 ng/mL (IQR = 5.5, p < 0.05), 2.95 ng/mL (IQR = 4.4, p < 0.05) and 2.00 ng/mL (IQR = 3.6, p < 0.001), respectively. After six, 12, and 24 months of SSLAR treatment, the respective median IGF-1 concentrations significantly decreased to 384.5 ng/mL (IQR = 312.2, p < 0.01), 323.0 ng/mL (IQR = 230.3, p < 0.001) and 334.0 ng/mL (IQR = 328.9, p < 0.01). The differences between median hGH and IGF-1 concentrations at 12 and 24 months were not significant. A statistically significant correlation was found between IGF-1 concentration prior to and after surgery (R = 0.61, p < 0.05) and prior to SSLAR treatment and IGF-1 concentration 24 months later (R = 0.49, p < 0.05). No such correlation was observed for hGH. CONCLUSIONS:The level of IGF-1 prior to surgery and prior to SSLAR treatment is a better predictor of the treatment outcome than hGH. Octreotide LAR was most effective over the first 12 months of treatment. No further significant decrease of hGH or IGF-1 levels was observed past this period.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Bałdys-Waligórska A,Krzentowska-Korek A,Gołkowski F,Sokołowski G,Hubalewska-Dydejczyk Asubject
Has Abstractpub_date
2011-01-01 00:00:00pages
401-8issue
5eissn
0423-104Xissn
2299-8306journal_volume
62pub_type
杂志文章abstract：:The treatment of Graves' orbitopathy (GO) remains a diagnostic and therapeutic challenge for clinicians worldwide. The elimination of risk factors, such as encouraging smoking cessation and achieving euthyroidism, are the most important and usually sufficient treatment methods in most mild cases. A course of selenium ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2014.0054
更新日期：2014-01-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-05-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,实务指引
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Endokrynologia Polska
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doi：
更新日期：2012-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-05-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章,评审
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