Abstract:
:Numerous members of semaphorins have been widely clarified to be involved in the development of multiple cancers. However, the semaphorin 6B (SEMA6B) has not yet been extensively reported in cancers, especially in thyroid carcinoma. According to the public dataset from TCGA database, we found that the expression of SEMA6B was upregulated in thyroid carcinoma tissues and high level of SEMA6B resulted in a poorer prognosis. Functional experiments showed that silencing SEMA6B suppressed B-CPAP cells viability, invasiveness and motility, whereas up-regulating SEMA6B in FTC-133 cells led to opposite outcomes. Furthermore, knockdown of SEMA6B in B-CPAP cells could significantly elevate the protein expression of NUMB and reduce the expression of NOTCH1, HES1, and Cyclin D1. Overexpression of SEMA6B in FTC-133 cells presented the inverse results. These findings demonstrated that SEMA6B exerts a tumorigenic effect in thyroid carcinoma by activating Notch signaling pathway, which provide a possible biomarker for thyroid carcinoma.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Lv XJ,Chen X,Wang Y,Yu S,Pang L,Huang Cdoi
10.5603/EP.a2020.0072subject
Has Abstractpub_date
2020-10-30 00:00:00eissn
0423-104Xissn
2299-8306pii
VM/OJS/J/68545pub_type
杂志文章abstract::The concentrations of beta-endorphin, ACTH, insulin (IRI), glucagon (IRG), cortisol and growth hormone were determined by radioimmunoassay during oral glucose tolerance test (OGTT) performed in 13 obese patients with normal glucose tolerance and without arterial hypertension. The test was performed in random, before a...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:Poorly differentiated thyroid carcinoma (PDTC, insular carcinoma) occurs rarely. It is described with more aggressive behaviour, poorer prognosis, and higher mortality than well differentiated thyroid carcinoma (WDTC). The aim of this study was to evaluate the clinical course of patients with PDTC, in addi...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract::Many mechanism may participate in the inhibition of thyroid function by excess of iodine. The present study was aimed at answering the question, whether the excess of iodine influences the activity of type I thyroxine 5'-deiodinase. To 40 female rats fed with standard diet a dose of 42 micrograms of iodine daily was a...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:In Romania, there is no acromegaly national register and there are no nationwide data available. However, some studies have reported the control rates in the country's main referral centres. Our aim was to assess the overall control rate in our tertiary referral centre. Also, we assessed the control rate i...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0020
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Adrenal pheochromocytoma are diagnosed the most often in patients with arterial hypertension or with thyroid medullar cancer and suspicion of MEN II syndromes. The aim of the study is to analyse the morphology of pheochromocytomas on the basis of Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) in o...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::The present study is aimed to present the potential role of thyroid hormones (TH) in the pathogenesis of glioblastoma multiforme (GBM). In first part of this presentation the effect of general homeostasis of TH on GBM formation and course was shown. Then the evidence concerning present state of the knowledge about act...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:10.5603/EP.2015.0055
更新日期:2015-01-01 00:00:00
abstract::The survey carried out in May 1991 in the city of Białystok comprised 308 children of age between 8 and 14 years and 116 young adults. In each of the studied subjects the size of the thyroid was measured by ultrasonography and iodine concentration determined in a randomly voided sample of urine. Body weight and height...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Thyroid cancer in children is rare and accounts for 1-3% of all malignant tumours. Differentiated thyroid cancers (DTC) and particularly papillary thyroid carcinoma (PTC) (90% of cases) are the most prevalent. Surgery is the mainstay of treatment in patients with DTC. The current recommendations are based not on prosp...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:10.5603/EP.a2019.0033
更新日期:2019-01-01 00:00:00
abstract::Not required for Clinical Vignette. ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0071
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:After thyroidectomy and radioiodine therapy, patients with differentiated thyroid cancer (DTC) are indefinitely treated with levothyroxine (L-T4). Osteoporosis is a debated consequence of hypothyroxinaemia. The aim of this study was to evaluate bone mineral density (BMD) and fracture risk assessed by FRAX ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2016.0046
更新日期:2016-01-01 00:00:00
abstract::Acromegaly can be treated with several medical modalities. The growth hormone (GH) receptor antagonist pegvisomant, in particular, is able to reduce serum insulin-like growth factor I (IGF-I) concentrations to almost any desired level. Along with this important achievement come other practical issues. The most importa...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2007-07-01 00:00:00
abstract::A case of rare association of hyperparathyroidism with fully developed hyperthyroidism appearing in a woman 23 years old with advanced generalized cystic fibrosis has been presented. ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Thyroid disorders are more frequently observed in diabetic patients. These conditions have been shown to be mainly of autoimmune origin and all of them may lead to hormonal imbalance. Especially strong links exist between autoimmune thyroid diseases (AITD) and type 1 diabetes. Importantly, both hypothyroidism and hype...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,实务指引
doi:
更新日期:2013-01-01 00:00:00
abstract::Ig-G4 related disease (IgG4RD) is a heterogeneous disorder with multi-organ involvement recognised as a separate entity at the start of this century only. It is currently one of the hottest areas of clinical and translational research across specialties. Thyroid involvement in IgG4RD is rare, believed to occur in less...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:10.5603/EP.2016.0061
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Despite considerable progress in knowledge, ischaemic stroke is still a disease that causes serious clinical problems. A role in its pathogenesis can be attributed to i.a. adipose tissue hormones. The aim of this paper is to assess the blood levels of selected adipocytokines in patients during the acute ph...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2019.0057
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS:41- year gentleman with 4-year histor...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2018.0016
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:The overexpression of nitric oxide synthase (NOS) has been found in tumours, including pituitary adenomas. It has also been found that NOS is overexpressed in human spontaneous pituitary adenomas. The question arises whether NOS and its product, nitric oxide (NO), are involved in pituitary tumourigenesis. ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::Diabetic kidney disease (DKD) remains the leading cause of the end-stage renal disease (ESRD) and the most common reason for renal replacement therapy. Research has been carried out for years to find a marker that would enable early identification of people at risk of DKD occurrence, as well as people who will progres...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0077
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:In this study, we aimed to investigate the relationship between glycated haemoglobin (HbA1c) levels and the severity of coronary artery disease (CAD) in < 40 years old patients. MATERIAL AND METHODS:The study population consisted of 211 premature coronary atherosclerotic patients (pCAP) (aged 36.4 ± 2.5 y...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2015.0042
更新日期:2015-01-01 00:00:00
abstract::Osteoporosis is a chronic disease of the osseous system characterised by decreased strength of bone tissue, which in turn leads to increased fracture risk. It has been demonstrated that osteoporosis affects more than 30% of women after the menopause (WHO, 1994). However, the disease is also observed in men. The primar...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract::The authors present numerous historical descriptions of persons who might suffered from gigantism or acromegaly. The oldest medical data of patients, initial attempts of causal neurosurgical treatment, history of growth hormone, insulin-like growth factor-1, growth hormone releasing hormone and somatostatin discovery ...
journal_title:Endokrynologia Polska
pub_type: 历史文章,杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:Childhood obesity has been associated with the development of insulin resistance, potentially leading to several metabolic disorders. Osteocalcin has been reported to contribute to the regulation of glucose tolerance and insulin sensitivity. The purpose of this study was to examine the relationship between...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2013.0016
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate the influence of body mass changes on plasma concentrations of proinflammatory cytokines in obese women after the initially obtained weight reduction in a five-year follow-up period. MATERIAL AND METHODS:Thirty out of 42 women with simple obesity (age 41.8 ± 11.9 year...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::Neuroendocrine neoplasms of the large intestine account for 20% of all neuroendocrine neoplasms (NENs) and are most commonly found in the rectum. The rate of detection of colorectal NENs is increasing, and this tendency will continue due to the widespread use of colonoscopy as a screening tool and the removal of all d...
journal_title:Endokrynologia Polska
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.5603/EP.2013.0032
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve breathing function in PWS, but the findings are not explicit. MATERIAL AND METHODS:Screening polysomnography- polygraphy (PSG...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2017.0057
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the clinical profile of BIAsp 30 (30% soluble insulin aspart, 70% protamine-crystallized insulin aspart) (NovoMix®)30) in type 2 diabetes patients in routine clinical practice in Iran. MATERIAL AND METHODS:IMPROVE™ was a 26-week, multinational, open-label, non-randomized study in patients with...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,多中心研究
doi:
更新日期:2010-07-01 00:00:00
abstract::Anorexia nervosa is an eating disorder characterized by conscious restriction of food intake, which causes numerous metabolic and hormonal disorders. Knowledge of these changes is important due to growing morbidity and mortality of anorexia. Treatment is difficult and requires cooperation of a group of specialists, in...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2008-03-01 00:00:00
abstract::Epidemiological foundation included: aim of studies, knowledge about epidemiology of thyroid disorders in Poland, evaluation of radioiodine dose accumulated in thyroids of inhabitants of different age living in different par of Poland, information about relative diet iodine deficiency in different parts of Poland and ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::The study was aimed at evaluation of usefulness of determination of blood serum 21-deoxycortisol concentration for the detection of heterozygous carriers of incomplete block of 21-hydroxylase synthesis leading to adrenal hyperplasia. An earlier observation of the authors that the determination of 21-deoxycortisol is a...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00