Abstract：
INTRODUCTION:Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve breathing function in PWS, but the findings are not explicit. MATERIAL AND METHODS:Screening polysomnography- polygraphy (PSG), assessing nasal respiratory flow, respiratory effort, and blood oxygen saturation, was used. Group 1 - before rhGH therapy (n = 11, mean age 3.0 years); PSG was repeated after the start of rhGH therapy in a mean time of 0.9 years in six patients (Group 1a). Group 2 - on rhGH treatment, for a mean time of four years (n = 17, mean age 8.8 years). Group 3 - without rhGH therapy due to severe obesity (n = 8, mean age 13.1 years). RESULTS:Group 1 - mean apnoea-hypopnoea index (AHI) was 10.2, oxygen desaturation index (ODI)- 36.3, Group 1a- AHI 12.0, ODI 60.9, Group 2-AHI 9.0, ODI 25.1, Group 3- AHI 8.2, ODI 22.0. ODI was significantly higher in Group 1a than in the other groups (p < 0.005), but not strictly related to SRBD. The results in Group 2 did not differ significantly from those of Group 1. CONCLUSIONS:Our study proves the high frequency of SRBD among PWS patients, with worsening of ODI after short-term rhGH therapy.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Lecka-Ambroziak A,Jędrzejczak M,Wysocka-Mincewicz M,Szalecki Mdoi
10.5603/EP.a2017.0057subject
Has Abstractpub_date
2017-01-01 00:00:00pages
676-681issue
6eissn
0423-104Xissn
2299-8306pii
VM/OJS/J/51111journal_volume
68pub_type
杂志文章abstract：INTRODUCTION:After thyroidectomy and radioiodine therapy, patients with differentiated thyroid cancer (DTC) are indefinitely treated with levothyroxine (L-T4). Osteoporosis is a debated consequence of hypothyroxinaemia. The aim of this study was to evaluate bone mineral density (BMD) and fracture risk assessed by FRAX ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2016.0046
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
abstract：:Epidemiological foundation included: aim of studies, knowledge about epidemiology of thyroid disorders in Poland, evaluation of radioiodine dose accumulated in thyroids of inhabitants of different age living in different par of Poland, information about relative diet iodine deficiency in different parts of Poland and ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
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journal_title：Endokrynologia Polska
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doi：
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doi：
更新日期：2008-05-01 00:00:00
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journal_title：Endokrynologia Polska
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doi：
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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journal_title：Endokrynologia Polska
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doi：
更新日期：1992-01-01 00:00:00
