Abstract：
INTRODUCTION:In this study, we aimed to investigate the relationship between glycated haemoglobin (HbA1c) levels and the severity of coronary artery disease (CAD) in < 40 years old patients. MATERIAL AND METHODS:The study population consisted of 211 premature coronary atherosclerotic patients (pCAP) (aged 36.4 ± 2.5 years) and 160 control subjects (36.4 ± 2.4 years). The severity of CAD was evaluated by the Gensini scoring system. HbA1c levels and the other basic biochemical parameters were analysed, and relations with severity of CAD were evaluated. RESULTS:There were statistically significant differences in serum HbA1c levels between the two groups (pCAP = 6.1 ± 1.8%, control = 4.7 ± 1.2%, p < 0.001). HbA1c levels significantly positively correlated with the Gensini score in pCAP (r = 0.662, p < 0.001). In linear multivariate regression analysis (including age, sex, HbA1c, smoking, diabetes mellitus and hypertension as dependent parameters), only HbA1c was found to be an independent risk factor for the presence of severe CAD (Beta = 0.374, p < 0.001). In ROC curve analysis, the optimal cut-off value of HbA1c to predict severe CAD was 6.52%, with 74.4% sensitivity and 75.1% specificity (area under the curve 0.781, 95% confidence interval 0.661 to 0.901, p < 0.001). CONCLUSIONS:HbA1c levels were found to be correlated with the Gensini score in pCAP with and without diabetes. In this respect, glucose metabolism abnormalities, indicated by HbA1c, may play an important role in premature CAD.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Ayhan SS,Tosun M,Ozturk S,Alcelik A,Ozlu MF,Erdem A,Erdem K,Erdem FH,Yazici Msubject
Has Abstractpub_date
2012-01-01 00:00:00pages
367-71issue
5eissn
0423-104Xissn
2299-8306journal_volume
63pub_type
杂志文章abstract：BACKGROUND:The activity of androgen receptor (AR) is modulated by a polymorphic region located within exon 1 its gene and characterizing a variable number of trinucleotide CAG repeats. The length of polymorphic region is inversely correlated with the transactivation function of AR gene. It was showed an ethnic differen...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：INTRODUCTION:Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. MATERIAL AND METHODS:Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 year...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0046
更新日期：2017-01-01 00:00:00
abstract：:Renalase is a recently identified flavoprotein oxidase, secreted mainly by the kidneys, which takes part in the degradation of catecholamines. The catecholamine inactivating effect results in the modulation of the sympathetic system tension and, consequently, in a decrease of blood pressure, myocardial contractility, ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0044
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS:mRNA expression of adipokines;...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2018.0091
更新日期：2019-01-01 00:00:00
abstract：:Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Primary aldosteronism is the commonest form of hormone-related hypertension, with an estimated prevalence of 6-13% in the generalpopulation of hypertensive patients. Among patients with resistant hypertension, the proportion of PA is even higher. Through intensiveresearch in the field of basic science and the creation...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/ep.2013.0011
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve breathing function in PWS, but the findings are not explicit. MATERIAL AND METHODS:Screening polysomnography- polygraphy (PSG...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0057
更新日期：2017-01-01 00:00:00
abstract：:Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are often used by athletes as doping agents. It is estimated that up to 25% of sportsmen using anabolic-androgenic steroids also take GH. Available data do not confirm the influence of GH or IGF-1 preparations on physical performance improvement. However, th...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2009-09-01 00:00:00
abstract：:In view of the fact that primary aldosteronism (PA) is a problem that is more prevalent than previously thought and its diagnosis is of greater clinical significance than previously believed, the Endocrine Society has recently published recommendations on the diagnosis and management of PA. Due to the fact that the cu...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to explore the association between thyroid hormones and abdominal fat quantities in euthyroid post-menopausal women. MATERIAL AND METHODS:Serum levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) as well as body mass index (BMI) and ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0037
更新日期：2020-01-01 00:00:00
abstract：:Anti-adrenal and anti-pituitary autoantibodies have been determined in 45 patients with autoimmune diseases of the thyroid, including 25 patients with Graves' disease and 20 patients with hypothyroidism of autoimmune origin. The determinations were carried out with the use of solid-phase RIA methods previously develop...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：INTRODUCTION:The clinical usefulness of baroreflex sensitivity (BRS) in the early detection of autonomic dysfunction in patients with diabetes is not well established. The aim of the study was the evaluation of BRS in subjects with type 1 diabetes with and without cardiovascular autonomic neuropathy (CAN). MATERIAL AN...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：:Questionnaire, clinical, ultrasonographic and biochemical studies (determination of urinary iodine concentration) have been carried out in 1686 children of age between 7 and 13 years living in the Lublin Upland region. The presence of goiter was found in 368 children (21.8%). A gradual increase in the incidence of goi...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：INTRODUCTION:Over the last decade, average life expectancy has continuously increased. There has been no data on normal sex hormone (SH) levels in a Polish elderly population. In this study, we assessed SH in the PolSenior cohort to determine normal reference ranges in relation to gender, age, and cardiovascular diseas...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:We present a case of a woman with unique multisystem disorder--POEMS syndrome and endocrine abnormalities coexisting with it. The POEMS acronym comprises the dominant features: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M protein), skin changes. Association between plasma cell dyscrasia and poly...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:An increased risk of mortality in patients with uncontrolled acromegaly has been reported in several studies. We aimed to assess the impact of co-morbidities on the survival of patients with acromegaly after long-term treatment and follow-up. MATERIAL AND METHODS:A retrospective analysis was performed for...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2016.0031
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:Generally, squamous cell carcinoma carries a poor prognosis because of its tendency to local invasion and subsequent metastasis, which is mediated by multiple factors and angiogenesis. Hepatocyte growth factor (HGF) is a potent mitogen for epithelial cells and regulates cell proliferation and migration and...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：INTRODUCTION:Fine needle aspiration biopsy (FNAB) of the thyroid nodules generally allows to make the diagnosis and to choose the proper clinical management. In about 10% of cases cytopathologic features do not differentiate unequivocally benign and malignant lesions. In these cases the cytopathologic diagnosis of foll...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:Omentin-1, secreted by visceral adipose tissue, has been indicated in the regulation of bone metabolism in girls with anorexia nervosa (AN). The aim of the study was to evaluate the relationship between omentin-1 and bone metabolism in girls with AN as well as the potential involvement of OPG and RANKL in ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0063
更新日期：2015-01-01 00:00:00
abstract：:Słowo wstępne do "Endokrynologia Polska" 69 (6) 2018. ...
journal_title：Endokrynologia Polska
pub_type： 信件
doi：
更新日期：2018-01-01 00:00:00
abstract：:Autoimmune polyglandular syndromes (APS) consist of a variety of endocrine and non-endocrine disorders. The syndromes are complex and their occurrence in life does not follow any pattern. Early detection of such disorders may prevent many serious clinical consequences which are usually a result of delayed diagnosis. W...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0070
更新日期：2014-01-01 00:00:00
abstract：:The introduction of sonographic imaging has revolutionized the diagnostics of thyroid pathologies. Nowadays, thyroid ultrasound examination has become an essential part of routine thyroid gland evaluation. Although one of the greatest advantages of this examination lies in its simplicity, it requires a solid theoretic...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：INTRODUCTION:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seld...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.a2018.0010
更新日期：2018-01-01 00:00:00
abstract：:Not required for Clinical Vignette. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0045
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:The present study aims to evaluate the incidence, types, timing and risk factors in amiodarone (AMD)-induced thyroid dysfunction. MATERIAL AND METHODS:The study comprised 229 patients from an iodine-replete area (115 women, 114 men, mean age 63.8 ± 9.2 years), chronically treated with AMD. The cases were ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:The aim of this review is to present the up-to-date information concerning the prevalence, pathogenesis, diagnosis and treatment of gynecomastia. Gynecomastia is a benign, unilateral or bilateral enlargement of the male breast due to the imbalance between the androgens and estrogens at the breast tissue level. This cl...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-05-01 00:00:00
abstract：:The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
abstract：:NIS gene is located on chromosome 19 and encodes 643 amino acid protein. It belongs to membrane Na+ dependent glucose symporter proteins family. In normal thyroid is located in basolateral membrane of thyreocyte. It plays a main role in concentrating of iodine in thyreocyte and thus in thyroid hormones synthesis. It w...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:The paper concerns osteonecrosis of the jaw (ONJ). It is a rare but serious clinical condition. It can develop in patients treated in oncologic doses with bisphosphonates but also with denosumab. In osteoporosis ONJ seems to be very rare. Definition, pathogenesis, risk factors, prevention and treatment, and the freque...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:The study was aimed at the assessment of frequency of occurrence of thyroid antimicrosomal and antithyreoglobuln autoantibodies in children with insulin-dependent diabetes and healthy control children. The occurrence of thyroid autoantibodies was analyzed with respect to the age and sex of children and the duration of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
