Abstract：
INTRODUCTION:Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS:mRNA expression of adipokines; adiponectin, resistin, tumour necrosis factor-a, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, and cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. RESULTS:We did not find any significant difference in the investigated genes; however, the almost significant overexpression of AGT and underexpression of IL-6 might be noteworthy (p = 0.06 in both cases). CONCLUSIONS:No significant differences were found in the expression of the investigated genes known as cardiometabolic risk factors. This indicates that there are no major differences between endogenous hypercortisolism or diet-induced obesity regarding the expression of adipokines involved in cardiometabolic disorders. However, the difference in AGT and IL-6 expression might be included in pathways affecting fat distribution in CS.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Denes J,Zsippai A,Kovacs L,Gorombey Z,Kovacs GL,Goth M,Igaz P,Hubina Edoi
10.5603/EP.a2018.0091subject
Has Abstractpub_date
2019-01-01 00:00:00pages
131-134issue
2eissn
0423-104Xissn
2299-8306pii
VM/OJS/J/59024journal_volume
70pub_type
杂志文章abstract：:One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves' hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive f...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:The effect of cholecystokinin octapeptide (CCK-8) on basal and TRH-stimulated secretion of TSH was investigated in 67 male Sprague-Dawley rats. Blood for TSH determinations was sampled by cannulation of right heart auricle in urethane narcosis before and four times during 60 minutes following CCK-8 administration. It ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：INTRODUCTION:Ghrelin is a polypeptide hormone secreted mainly by the stomach cells, stimulating food intake and growth hormone release. Decreased plasma ghrelin concentration was found in obese subjects. Clinical and experimental data suggest that ghrelin also exerts a blood pressure lowering property. The influence of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Increased interest in vitamin D measurements in clinical studies has contributed to the development in recent years of several new immunochemical assays (manual and for automatic analyzers). New methods, including HPLC (high performance liquid chromatography), and LC-MS/MS (liquid chromatography coupled with tandem ma...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Fine needle aspiration biopsy (FNAB) of the thyroid nodules generally allows to make the diagnosis and to choose the proper clinical management. In about 10% of cases cytopathologic features do not differentiate unequivocally benign and malignant lesions. In these cases the cytopathologic diagnosis of foll...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Questionnaire, clinical, ultrasonographic and biochemical studies (determination of urinary iodine concentration) have been carried out in 1686 children of age between 7 and 13 years living in the Lublin Upland region. The presence of goiter was found in 368 children (21.8%). A gradual increase in the incidence of goi...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：INTRODUCTION:This study presents a 10-year longitudinal assessment of bone status in adolescents and young adults with type 1 diabetes (T1D). MATERIAL AND METHODS:Thirty-two patients (12 female, aged 20.5 ± 3.93 years, T1D duration 13.9 ± 1.97 years) were studied using quantitative ultrasound (QUS) and dual-energy X-r...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0080
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abstract：:A case of rare association of hyperparathyroidism with fully developed hyperthyroidism appearing in a woman 23 years old with advanced generalized cystic fibrosis has been presented. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,多中心研究
doi：10.5603/EP.2016.0066
更新日期：2016-01-01 00:00:00
abstract：:Hormony tarczycy (thyroid hormones, TH) są zaangażowane w wiele różnych procesów biologicznych, wliczając rozwój układu nerwowego, regulację metabolizmu pośredniego oraz zużycie energii. Aktywnie uczestniczą w podstawowym zużyciu energii i termogenezie adaptacyjnej i z tego względu mogą mieć wpływ na masę ciała w prze...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:We describe a 37 year-old woman case of latent autoimmune diabetes in adults (LADA). She was presented with unfounded weight loss. The diagnosis of diabetes mellitus was established on twice plasma glucose measurements above 200 mg/dl. In other routine biochemical examinations we did not observe dehydratation, electro...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.a2018.0073
更新日期：2018-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：:The present study is aimed to present the potential role of thyroid hormones (TH) in the pathogenesis of glioblastoma multiforme (GBM). In first part of this presentation the effect of general homeostasis of TH on GBM formation and course was shown. Then the evidence concerning present state of the knowledge about act...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0072
更新日期：2020-10-30 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Blood serum concentrations of thyrotropic hormone (TSH), triiodothyronine (T3), thyroxine (T4) and cortisol have been measured in 50 patients with duodenal ulcer. The determinations were repeated after a specific time of treatment with ranitidine: in 45 patients after 3 weeks and in 37 after additional 30 days of trea...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-05-01 00:00:00
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journal_title：Endokrynologia Polska
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doi：
更新日期：2009-03-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 历史文章,杂志文章
doi：
更新日期：2008-05-01 00:00:00
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journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The World Health Organization (WHO) issued a recommendation (Technical Consultation: Paris 2006, Luxembourg 2007) that salt consumption, as a risk factor for hypertension, atherosclerosis, myocardial infarction, stroke, and select cancers, should be restricted. The European Commission looked to adhere to this recommen...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Cushing's disease (CD) is caused by an adrenocorticotrophin (ACTH) secreting pituitary adenoma and it is the commonest cause of endogenous hypercortisolism. When high suspicion of Cushing's syndrome (CS) exists, recommended screening tests include the overnight dexamethasone suppression test, the low-dose dexamethason...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Secretory products from adipocytes may contribute to deterioration in glycaemic control and increased insulin resistance (IR). Retinol-binding protein 4 (RBP-4) may increase IR in mice, with elevated levels in insulin-resistant mice and humans with obesity and type 2 diabetes. However, the mechanisms regul...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
