Abstract:
:The authors present the current knowledge on the intracellular mechanisms of thyroid hormone action in the cardiomyocytes. Many of the clinical manifestations of thyroid diseases are due to the ability of thyroid hormone to alter cardiovascular hemodynamics. Triiodothyronine affects the hemodynamic state mainly by its influence on the expression of cardiomyocyte genes. These genes encode both structural and regulatory proteins in the heart (myosin heavy chains, sarcoplasmic reticulum calcium-activated ATP-ase, phospholamban). The impaired myocardium contractile activity in hypothyreosis reminds findings in heart failure and may warrant further exploration of therapeutic approaches using thyroid hormone to improve cardiac function in heart failure.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Gatnar A,Marek B,Pakuła D,Kajdaniuk D,Kos-Kudła B,Borgiel-Marek H,Gnot R,Pakuła P,Pawłowska Msubject
Has Abstractpub_date
2006-03-01 00:00:00pages
144-8issue
2eissn
0423-104Xissn
2299-8306journal_volume
57pub_type
杂志文章,评审abstract:INTRODUCTION:Aim of the study was present personal observations connected with the management of patients referred to surgical treatment for secondary hyperparathyroidism (SHT) or tertiary hyperparathyroidism (THT), and to assess immediate results of such management. MATERIAL AND METHODS:A total of 175 patients aged 2...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract::One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves' hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive f...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2006-09-01 00:00:00
abstract:INTRODUCTION:Vitamin D receptor (VDR) is encoded by the VDR gene. Several studies have supported that this gene is associated with diabetes. Heterodimer VDR/RXR functions as an enhancer of the BGLAP gene and increases the basal transcription rate of osteocalcin (OC) during osteoblast differentiation. OC is a regulator ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2015.0042
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Surgery remains the most effective treatment for primary hyperparathyroidism (PHPT). Minimally invasive radioguided parathyroidectomy (MIRP) is a common technique for detecting and excising abnormal parathyroid glands. The aim of this study was to compare injections of low-dose and high-dose (99m) Tc metho...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2017.0031
更新日期:2017-01-01 00:00:00
abstract::A case of rare association of hyperparathyroidism with fully developed hyperthyroidism appearing in a woman 23 years old with advanced generalized cystic fibrosis has been presented. ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,实务指引
doi:10.5603/EP.2018.0046
更新日期:2018-01-01 00:00:00
abstract::The paper presents actual data concerning osteoporotic fractures (definitions, causes, epidemiologic and clinical data, consequences, treatment) particulary data about the most common fractures (distal forearm, vertebral and proximal hip fractures). ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2009-11-01 00:00:00
abstract::A group of 153 patients with scintigraphically detected autonomic "hot" nodules of the thyroid has been subjected to clinical and histopathological analysis. Substantial part of these patients (30.1%) had hyperthyroidism, partly (in 19.9% of cases) in the form of the thyrocardiac syndrome. A most frequent histopatholo...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are often used by athletes as doping agents. It is estimated that up to 25% of sportsmen using anabolic-androgenic steroids also take GH. Available data do not confirm the influence of GH or IGF-1 preparations on physical performance improvement. However, th...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2009-09-01 00:00:00
abstract:INTRODUCTION:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seld...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:10.5603/EP.a2018.0010
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the clinical profile of BIAsp 30 (30% soluble insulin aspart, 70% protamine-crystallized insulin aspart) (NovoMix®)30) in type 2 diabetes patients in routine clinical practice in Iran. MATERIAL AND METHODS:IMPROVE™ was a 26-week, multinational, open-label, non-randomized study in patients with...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,多中心研究
doi:
更新日期:2010-07-01 00:00:00
abstract::The process of angiogenesis in a heart muscle is a way of providing the ischaemic myocardium with oxygen and nutritive ingredients. This natural process called therapeutic angiogenesis has been tried in the treatment of patients with coronary artery disease mainly. It has been seen as a chance of an effective benefici...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:Oxytocin might be used therapeutically as an ally to rescue osteopathy resulting from diabetes. However, the in vivo effects of oxytocin on marrow adipogenesis in diabetes remain unknown. In this longitudinal study, we aimed to investigate the protective ef-fects of oxytocin on diabetes-induced marrow adip...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2018.0040
更新日期:2018-01-01 00:00:00
abstract::Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:In Romania, there is no acromegaly national register and there are no nationwide data available. However, some studies have reported the control rates in the country's main referral centres. Our aim was to assess the overall control rate in our tertiary referral centre. Also, we assessed the control rate i...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0020
更新日期:2020-01-01 00:00:00
abstract::The study, supported by program MZ-XVII, was carried on 4567 inhabitants of the area of Szczecin (2350 females and 2217 males). The population was chosen randomly, according to a simple drawing scheme. All subjects were clinically examined using standardised questionnaires. In 3468 persons (including 1807 girls and wo...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:papillary thyroid microcarcinoma is a well-known malignant neoplasm with good prognosis. The known prognostic factors are patient's age, multifocality, and extrathyroidal extension. CD9 and CD82, members of the tetraspanin family, are expressed in numerous cancer cells and play many roles associated with t...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2019.0009
更新日期:2019-01-01 00:00:00
abstract::Hypocalcemic response following the administration of 160 units of porcine calcitonin was investigated in 14 patients with bone lesions caused by myeloma and in 9 control subjects. Significant decrease in blood serum calcium level was found in 85 per cent of myeloma patients, both in those with osteolytic bone lesions...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Diabetic kidney disease (DKD) remains the leading cause of the end-stage renal disease (ESRD) and the most common reason for renal replacement therapy. Research has been carried out for years to find a marker that would enable early identification of people at risk of DKD occurrence, as well as people who will progres...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0077
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Although both statins and fibrates have been found to reduce monocyte cytokine release, no study has investigated whether the effect of hypolipidaemic agents depends on age. MATERIAL AND METHODS:This study retrospectively analysed the results of 65 patients with type 2 diabetes and atherogenic dyslipidaem...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2016.0021
更新日期:2016-01-01 00:00:00
abstract::Obesity and thyroid function are closely related. Thyroid hormones are involved in the regulation of metabolism, thermogenesis, food intake, and fat oxidation. In obese children the most frequent hormonal abnormalities are slight hyperthyrotropinaemia and moderate increases in total T3 and/or fT3 concentrations. Those...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:10.5603/EP.2017.0007
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The recent investigations point out the significant role of oxidative stress in the development of thyroid gland disease. The present study was designed to investigate the variation of oxidative stae in women with non-autoimmunological subclinical hyperthyroidism. MATERIAL AND METHODS:The study was conduc...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2009-05-01 00:00:00
abstract::Osteoporosis is a chronic disease of the osseous system characterised by decreased strength of bone tissue, which in turn leads to increased fracture risk. It has been demonstrated that osteoporosis affects more than 30% of women after the menopause (WHO, 1994). However, the disease is also observed in men. The primar...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-01 00:00:00
abstract::Autoimmune polyglandular syndromes (APS) consist of a variety of endocrine and non-endocrine disorders. The syndromes are complex and their occurrence in life does not follow any pattern. Early detection of such disorders may prevent many serious clinical consequences which are usually a result of delayed diagnosis. W...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2014.0070
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye. MATERIAL AND METHODS:30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulf...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2014.0038
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The exact aetiology is unknown. However, genetic and environmental factors are suggested to be involved in the pathogenesis of MS. Improper diet, resulting in obesity and metabolic syndrome, can contribute to this disease. Adip...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0008
更新日期:2020-01-01 00:00:00
abstract::The introduction of sonographic imaging has revolutionized the diagnostics of thyroid pathologies. Nowadays, thyroid ultrasound examination has become an essential part of routine thyroid gland evaluation. Although one of the greatest advantages of this examination lies in its simplicity, it requires a solid theoretic...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Children's obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high ra...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Endocrinological Out-Patients Clinic at Children's Hospital in Dziekanów Leśny takes care of the children from Mazovia region. Hormonal findings in children with simple goiter were analyzed in several groups of patients. In all those patients preferential T3-secretion and decreased T4 production was found. These findi...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:The present study aims to evaluate the incidence, types, timing and risk factors in amiodarone (AMD)-induced thyroid dysfunction. MATERIAL AND METHODS:The study comprised 229 patients from an iodine-replete area (115 women, 114 men, mean age 63.8 ± 9.2 years), chronically treated with AMD. The cases were ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00