Abstract:
:One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves' hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive for thyroid stimulating antibody (TSAb) and anti-thyroid peroxidase autoantibodies (aTPO) while her brother remained euthyroid, seronegative for TSAb, and showed no clinical signs of thyroid pathology. The genetic studies of lymphocytes FISH (fluorescence in situ hybridization) and analysis of STR (short tandem repeated) fragments suggested, that lymphocytes responsible for hyperthyroidisms were of donor origin.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Jakubas B,Kostecka-Matyja M,Darczuk A,Gil Jsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
541-3issue
5eissn
0423-104Xissn
2299-8306journal_volume
57pub_type
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journal_title:Endokrynologia Polska
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journal_title:Endokrynologia Polska
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journal_title:Endokrynologia Polska
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