[Graves-Basedow disease after allogeneic bone marrow transplantation].

Abstract:

:One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves' hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive for thyroid stimulating antibody (TSAb) and anti-thyroid peroxidase autoantibodies (aTPO) while her brother remained euthyroid, seronegative for TSAb, and showed no clinical signs of thyroid pathology. The genetic studies of lymphocytes FISH (fluorescence in situ hybridization) and analysis of STR (short tandem repeated) fragments suggested, that lymphocytes responsible for hyperthyroidisms were of donor origin.

journal_name

Endokrynol Pol

journal_title

Endokrynologia Polska

authors

Jakubas B,Kostecka-Matyja M,Darczuk A,Gil J

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

541-3

issue

5

eissn

0423-104X

issn

2299-8306

journal_volume

57

pub_type

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