当前位置： SCI文献检索 > Endokrynologia Polska期刊下所有文献 > Oxytocin treatment prevents marrow adiposity observed in alloxan-induced diabetic rabbits using proton MR spectroscopy.

Oxytocin treatment prevents marrow adiposity observed in alloxan-induced diabetic rabbits using proton MR spectroscopy.

Abstract：

INTRODUCTION:Oxytocin might be used therapeutically as an ally to rescue osteopathy resulting from diabetes. However, the in vivo effects of oxytocin on marrow adipogenesis in diabetes remain unknown. In this longitudinal study, we aimed to investigate the protective ef-fects of oxytocin on diabetes-induced marrow adiposity in rabbits using proton MR spectroscopy. MATERIAL AND METHODS:Forty-five female New Zealand rabbits were randomly divided into controls, diabetes, and diabetes treated with oxytocin (ip, 0.78 mg/kg) for six months. Marrow fat fraction (FF) was determined by proton MR spectroscopy at baseline, and at three and six months. Bone mineral density was measured by dual-energy X-ray absorptiometry. Serum biomarkers, glycolipid metabolism, and histological analysis of marrow adipocytes were determined. RESULTS:Oxytocin treatment had positive metabolic effects in diabetic rabbits, which was based on the changes in glucose metabolism, insulin sensitivity, and lipid profiles. The diabetic rabbits demonstrated dramatic marrow adiposity in a time-dependent manner; at three and six months the FF percentage changes from baseline were 10.1% and 25.8%, respectively (all P < 0.001). Moreover, oxytocin treatment significantly reversed FF values and quantitative parameters of marrow adipocyte in diabetic rabbits to levels of naive control rabbits. Oxytocin improved bone formation marker in diabetic rabbits compared to the saline group. Also, treatment of diabetic rabbits with oxytocin significantly mitigated bone deterioration when compared with the saline-treated diabetic group (all P < 0.05). CONCLUSIONS:Oxytocin appears to alleviate harmful effects of hyperglycaemia on marrow adiposity. Proton MR spectroscopy may be a valuable tool, providing complementary information on efficacy assessments.

journal_name

Endokrynol Pol

journal_title

Endokrynologia Polska

authors

Lin H,Zheng M,Mao X,Feng X,Li J,Rao G,Lin F

doi

10.5603/EP.a2018.0040

subject

Has Abstract

pub_date

2018-01-01 00:00:00

issue

4

eissn

0423-104X

issn

2299-8306

pii

VM/OJS/J/55084

journal_volume

69

pub_type

杂志文章

相关文献

Endokrynologia Polska文献大全
  • [The role of cholecystokinin octapeptide (CCK-8) in regulating thyrotropin secretion in rats. In vivo studies].

    abstract：:The effect of cholecystokinin octapeptide (CCK-8) on basal and TRH-stimulated secretion of TSH was investigated in 67 male Sprague-Dawley rats. Blood for TSH determinations was sampled by cannulation of right heart auricle in urethane narcosis before and four times during 60 minutes following CCK-8 administration. It ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Krowicki ZK,Sadowska-Krowicka H

    更新日期：1989-01-01 00:00:00

  • WHO fracture risk calculator (FRAX) in the assessment of obese patients with osteoporosis.

    abstract：INTRODUCTION:Recently, a new fracture risk-assessment calculator (FRAX) has been introduced. The aim of this study was to assess its usefulness for the re-assessment of fracture risk in obese patients and re-assignment to treatment. MATERIAL AND METHODS:350 obese female patients were included. In all of them, 10-year ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Franek E,Wichrowska H,Gozdowski D,Puzianowska-Kuźnicka M

    更新日期：2009-03-01 00:00:00

  • Glycated haemoglobin is correlated with the severity of coronary artery disease independently of traditional risk factors in young patients.

    abstract：INTRODUCTION:In this study, we aimed to investigate the relationship between glycated haemoglobin (HbA1c) levels and the severity of coronary artery disease (CAD) in < 40 years old patients. MATERIAL AND METHODS:The study population consisted of 211 premature coronary atherosclerotic patients (pCAP) (aged 36.4 ± 2.5 y...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Ayhan SS,Tosun M,Ozturk S,Alcelik A,Ozlu MF,Erdem A,Erdem K,Erdem FH,Yazici M

    更新日期：2012-01-01 00:00:00

  • A case of premature ovarian failure (POF) in a 31-year-old woman with a 47,XXX karyotype.

    abstract：:A case of POF in a 31-year-old woman with karyotype 47,XXX. The aim of the study was to discuss a case of POF in a 31-year-old patient with polysomy 47,XXX. The described karyotype is not usually associated with this characteristic physical phenotype. In some rare cases, menstrual disorders, sterility, secondary ameno...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Skałba P,Cygal A,Gierzyńska Z

    更新日期：2010-03-01 00:00:00

  • [Comparison of CD15, galectin-3 and HBME-1 expression in follicular thyroid neoplasms].

    abstract：INTRODUCTION:Estimation of malignancy in thyroid follicular neoplasms is a common diagnostic problem, thus revealing of differences in expression of some antigens in both benign and malignant lesions seems to be essential. The aim of this study is to evaluate the immunohistochemical expression of CD15, galectin-3 and H...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Bogdańska M,Górnicka B,Ziarkiewicz-Wróblewska B,Koperski L,Morton M,Wasiutyński A

    更新日期：2006-07-01 00:00:00

  • Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan.

    abstract：INTRODUCTION:Children's obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high ra...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Adibi A,Kelishadi R,Beihaghi A,Salehi H,Talaei M

    更新日期：2009-01-01 00:00:00

  • [The POEMS syndrome with coexisting endocrinopathy--case report].

    abstract：:We present a case of a woman with unique multisystem disorder--POEMS syndrome and endocrine abnormalities coexisting with it. The POEMS acronym comprises the dominant features: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M protein), skin changes. Association between plasma cell dyscrasia and poly...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Lizis-Kolus K,Kowalska A,Nowakowska-Domagała M

    更新日期：2007-05-01 00:00:00

  • Effects of nitric oxide synthase inhibition on diethylstilbestrol-induced hyperprolactinaemia and pituitary tumourigenesis in rats.

    abstract：INTRODUCTION:The overexpression of nitric oxide synthase (NOS) has been found in tumours, including pituitary adenomas. It has also been found that NOS is overexpressed in human spontaneous pituitary adenomas. The question arises whether NOS and its product, nitric oxide (NO), are involved in pituitary tumourigenesis. ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Pawlikowski M,Pisarek H,Fryczak J,Stępień H

    更新日期：2012-01-01 00:00:00

  • [Venopunction of the cubital vein as an alternative approach for CGRP plasma level evaluation in tmd patients].

    abstract：INTRODUCTION:Calcitonin gene-related peptide is an important vasodilator. It plays an important role in the metabolism of chewing muscles. The aim of the study was to evaluate the plasma level of CGRP in patients with myofascial pain (RDC/TMD Ia) and myofascial pain with limited opening (RDC/TMD Ib) before and after oc...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,随机对照试验

    doi：10.5603/EP.2017.0025

    authors： Nitecka-Buchta A,Marek B,Kapustecka JB,Baron S

    更新日期：2017-01-01 00:00:00

  • [Behavior of thyrotropic, triiodothyronine, thyroxine and cortisol hormone levels in blood serum of patients with duodenal ulcer treated with ranitidine].

    abstract：:Blood serum concentrations of thyrotropic hormone (TSH), triiodothyronine (T3), thyroxine (T4) and cortisol have been measured in 50 patients with duodenal ulcer. The determinations were repeated after a specific time of treatment with ranitidine: in 45 patients after 3 weeks and in 37 after additional 30 days of trea...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Przybyłowski J,Kowalski D,Widłak H,Kowalska K,Garmulewicz M

    更新日期：1991-01-01 00:00:00

  • Polyendocrine autoimmunity in thyroid diseases.

    abstract：:Anti-adrenal and anti-pituitary autoantibodies have been determined in 45 patients with autoimmune diseases of the thyroid, including 25 patients with Graves' disease and 20 patients with hypothyroidism of autoimmune origin. The determinations were carried out with the use of solid-phase RIA methods previously develop...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Gryczyńska M,Baumann-Antczak A,Kosowicz J

    更新日期：1993-01-01 00:00:00

  • The clinical course of poorly differentiated thyroid carcinoma (insular carcinoma) - own observations.

    abstract：INTRODUCTION:Poorly differentiated thyroid carcinoma (PDTC, insular carcinoma) occurs rarely. It is described with more aggressive behaviour, poorer prognosis, and higher mortality than well differentiated thyroid carcinoma (WDTC). The aim of this study was to evaluate the clinical course of patients with PDTC, in addi...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Walczyk A,Kowalska A,Sygut J

    更新日期：2010-09-01 00:00:00

  • Orbital radiotherapy in the management of Graves' orbitopathy--current state of knowledge.

    abstract：:The treatment of Graves' orbitopathy (GO) remains a diagnostic and therapeutic challenge for clinicians worldwide. The elimination of risk factors, such as encouraging smoking cessation and achieving euthyroidism, are the most important and usually sufficient treatment methods in most mild cases. A course of selenium ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,评审

    doi：10.5603/EP.2014.0054

    authors： Ruchała M,Hernik A,Zybek A

    更新日期：2014-01-01 00:00:00

  • [Family incidence of latent autoimmune diabetes in adults--case report].

    abstract：:We describe a 37 year-old woman case of latent autoimmune diabetes in adults (LADA). She was presented with unfounded weight loss. The diagnosis of diabetes mellitus was established on twice plasma glucose measurements above 200 mg/dl. In other routine biochemical examinations we did not observe dehydratation, electro...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Szepietowska B,Szelachowska M,Górska M

    更新日期：2006-05-01 00:00:00

  • [The influence of vitamin D deficiency on cancers and autoimmune diseases development].

    abstract：:There is a growing number of diseases which prevalence can be associated with vitamin D deficiency. The link between low cholecalciferol concentration and bone diseases is well established, however there is also data suggesting that it may influence development and progression of different cancers and autoimmune disea...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,评审

    doi：

    authors： Kuryłowicz A,Bednarczuk T,Nauman J

    更新日期：2007-03-01 00:00:00

  • The real costs of acromegaly: analysis of different therapies.

    abstract：:Acromegaly is a rare, chronic condition caused by growth hormone (GH) overproduction, usually due to a benign tumour of the pituitary gland. During the disease many complications occur, including cardiovascular disease and changes in the musculoskeletal, respiratory, and endocrine systems. Treatment includes surgery, ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,评审

    doi：10.5603/EP.a2018.0080

    authors： Elbaum M,Mizera Ł,Bolanowski M

    更新日期：2019-01-01 00:00:00

  • Studies on goiter occurrence and iodine deficiency in Lublin Upland (Lublin coordinating center).

    abstract：:Questionnaire, clinical, ultrasonographic and biochemical studies (determination of urinary iodine concentration) have been carried out in 1686 children of age between 7 and 13 years living in the Lublin Upland region. The presence of goiter was found in 368 children (21.8%). A gradual increase in the incidence of goi...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Szewczyk L,Beń-Skowronek I,Jaklińska T,Lozowski C

    更新日期：1993-01-01 00:00:00

  • The effect of hypolipidemic treatment on monocyte cytokine release in different age groups of patients with type 2 diabetes and atherogenic dyslipidemia.

    abstract：INTRODUCTION:Although both statins and fibrates have been found to reduce monocyte cytokine release, no study has investigated whether the effect of hypolipidaemic agents depends on age. MATERIAL AND METHODS:This study retrospectively analysed the results of 65 patients with type 2 diabetes and atherogenic dyslipidaem...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：10.5603/EP.a2016.0021

    authors： Krysiak R,Gdula-Dymek A,Marek B,Okopień B

    更新日期：2016-01-01 00:00:00

  • Comparison of thyroid volume and goiter measured by means of ultrasonography and SPECT with use of 131I and 99m)c in smokers and non-smokers.

    abstract：INTRODUCTION:The aim of the study was to estimate the influence of nicotine on thyroid volume according to patients' sex. MATERIAL AND METHODS:A group of 160 patients with thyroid disorders in their past medical history was examined. Patients were divided into two groups: Group A contained 50 patients with goiter, whe...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Gierach M,Gierach J,Junik R

    更新日期：2009-11-01 00:00:00

  • [Sexual dysfunctions in selected endocrinopathies].

    abstract：:According to the socio-sexological reports approximately 40-45% of women and up to 30% of males may suffer from different sexual dysfunctions. The prevalence of those disorders is gradually increasing with age. Multiply numbers of endocrinopathies may influence the human sexual life. In diabetic patients all phases of...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,评审

    doi：

    authors： Skrzypulec V,Nowosielski K,Drosdzol A,Kowalaczyk R

    更新日期：2005-11-01 00:00:00

  • The medical treatment of acromegaly.

    abstract：:Acromegaly can be treated with several medical modalities. The growth hormone (GH) receptor antagonist pegvisomant, in particular, is able to reduce serum insulin-like growth factor I (IGF-I) concentrations to almost any desired level. Along with this important achievement come other practical issues. The most importa...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,评审

    doi：

    authors： van der Lely AJ

    更新日期：2007-07-01 00:00:00

  • [Acromegaly--from myths to facts].

    abstract：:The authors present numerous historical descriptions of persons who might suffered from gigantism or acromegaly. The oldest medical data of patients, initial attempts of causal neurosurgical treatment, history of growth hormone, insulin-like growth factor-1, growth hormone releasing hormone and somatostatin discovery ...

    journal_title：Endokrynologia Polska

    pub_type： 历史文章,杂志文章

    doi：

    authors： Kałuzny M,Bolanowski M

    更新日期：2008-05-01 00:00:00

  • [Growth hormone and IGF-1 as doping agents in competitive sport].

    abstract：:Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are often used by athletes as doping agents. It is estimated that up to 25% of sportsmen using anabolic-androgenic steroids also take GH. Available data do not confirm the influence of GH or IGF-1 preparations on physical performance improvement. However, th...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,评审

    doi：

    authors： Jóźków P,Medraś M

    更新日期：2009-09-01 00:00:00

  • New classification of thyroid FNAB results - a three-year observation from one clinic.

    abstract：INTRODUCTION:Fine needle aspiration biopsy (FNAB) is the main examination in diagnostics of thyroid nodules. Yet, it does not allow the differentiation of follicular lesions (FL). A new classification of thyroid biopsy results (newC) might improve pre-operative diagnostics mainly due to the introduction of a new subcat...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：10.5603/EP.2014.0060

    authors： Woźniak-Oseła E,Popowicz B,Sporny S,Klencki M,Słowińska-Klencka D

    更新日期：2014-01-01 00:00:00

  • Anaplastic thyroid carcinoma with rapid thyrotoxicosis - a case report and the literature review.

    abstract：INTRODUCTION:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seld...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,评审

    doi：10.5603/EP.a2018.0010

    authors： Daroszewski J,Paczkowska K,Jawiarczyk-Przybyłowska A,Bolanowski M,Jeleń M

    更新日期：2018-01-01 00:00:00

  • [A case associating primary parathyroid hyperfunction with hyperthyroidism].

    abstract：:A case of rare association of hyperparathyroidism with fully developed hyperthyroidism appearing in a woman 23 years old with advanced generalized cystic fibrosis has been presented. ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Plamieniak Z,Głebowska-Halawa H,Bednorz W,Komorski A

    更新日期：1992-01-01 00:00:00

  • The polycystic ovary syndrome: a position statement from the Polish Society of Endocrinology, the Polish Society of Gynaecologists and Obstetricians, and the Polish Society of Gynaecological Endocrinology.

    abstract：:Polycystic ovary syndrome (PCOS) diagnosis and therapy still arouse a lot of controversy. Each year brings new information, so, having collected the experience of three scientific societies, we present contemporary recommendations concerning PCOS diagnostics and treat-ment. In adult female diagnosis, we still use the ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章,实务指引

    doi：10.5603/EP.2018.0046

    authors： Milewicz A,Kudła M,Spaczyński RZ,Dębski R,Męczekalski B,Wielgoś M,Ruchała M,Małecka-Tendera E,Kos-Kudła B,Jędrzejuk D,Zachurzok A

    更新日期：2018-01-01 00:00:00

  • [Epidemiologic foundation for population studies of program MZ-XVII].

    abstract：:Epidemiological foundation included: aim of studies, knowledge about epidemiology of thyroid disorders in Poland, evaluation of radioiodine dose accumulated in thyroids of inhabitants of different age living in different par of Poland, information about relative diet iodine deficiency in different parts of Poland and ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Nauman J,Roszkowska H

    更新日期：1991-01-01 00:00:00

  • [Five year remission of GHRH secreting bronchial neuroendocrine tumor with symptoms of acromegaly. Utility of chromogranin A in the monitoring of the disease].

    abstract：:Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case ...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：

    authors： Bolanowski M,Kos-Kudła B,Rzeszutko M,Marciniak M,Zatońska K

    更新日期：2006-01-01 00:00:00

  • Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

    abstract：INTRODUCTION:Meteorin-like (Metrnl), also known as subfatin, is a recently discovered adipokine with a favourable effect on insulin sensitivity. Studies have shown lower Metrnl levels in obese patients. However, data on its circulating levels in type 2 diabetes mellitus (T2DM) patients are contradictory. This study aim...

    journal_title：Endokrynologia Polska

    pub_type： 杂志文章

    doi：10.5603/EP.a2020.0038

    authors： Onalan E,Cavlı C,Dogan Y,Onalan E,Gozel N,Buran I,Yakar B,Donder E

    更新日期：2020-01-01 00:00:00