Abstract：
:Many mechanism may participate in the inhibition of thyroid function by excess of iodine. The present study was aimed at answering the question, whether the excess of iodine influences the activity of type I thyroxine 5'-deiodinase. To 40 female rats fed with standard diet a dose of 42 micrograms of iodine daily was administered into the stomach through the gastric tube. Control group consisting of 10 rats received standard diet only. Part of the animals was sacrificed after each of the consecutive time intervals (2, 4, 7 and 14 days of treatment with iodine) and the activity of deiodinase in the thyroid as well as the blood serum levels of hormones, T3 and T4, were determined. A decrease in the activity of deiodinase in comparison with control group was observed during the whole experiment, the highest inhibition occurring after 4 days of treatment with iodine. A fall in the concentration of T3 was observed after the second and fourth dose of iodine, with no change in T4 concentration. The results of the experiments indicate that the excess of iodine inhibits the activity of type I thyroxine 5'-deiodinase in the thyroid.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Bednarczuk T,Pietrzykowski A,Słoń M,Nauman Asubject
Has Abstractpub_date
1993-01-01 00:00:00pages
405-12issue
4eissn
0423-104Xissn
2299-8306journal_volume
44pub_type
杂志文章abstract：:Elevated levels of serum glucose have deleterious effects on the walls of blood vessels, leading to microangiopathy. Such a destructive process involves also pulmonary circulation, where it is referred to as diabetic pulmonary microangiopathy. This hypothesis has been confirmed in histopathologic examinations of pulmo...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:A group of 153 patients with scintigraphically detected autonomic "hot" nodules of the thyroid has been subjected to clinical and histopathological analysis. Substantial part of these patients (30.1%) had hyperthyroidism, partly (in 19.9% of cases) in the form of the thyrocardiac syndrome. A most frequent histopatholo...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Numerous members of semaphorins have been widely clarified to be involved in the development of multiple cancers. However, the semaphorin 6B (SEMA6B) has not yet been extensively reported in cancers, especially in thyroid carcinoma. According to the public dataset from TCGA database, we found that the expression of SE...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0072
更新日期：2020-10-30 00:00:00
abstract：:The aim of this review is to present the up-to-date information concerning the prevalence, pathogenesis, diagnosis and treatment of gynecomastia. Gynecomastia is a benign, unilateral or bilateral enlargement of the male breast due to the imbalance between the androgens and estrogens at the breast tissue level. This cl...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-05-01 00:00:00
abstract：INTRODUCTION:The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content. MATERIAL AND METHODS:We studied two age-, we...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0013
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:The aim of the study was to estimate the influence of nicotine on thyroid volume according to patients' sex. MATERIAL AND METHODS:A group of 160 patients with thyroid disorders in their past medical history was examined. Patients were divided into two groups: Group A contained 50 patients with goiter, whe...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:Blood serum concentrations of thyrotropic hormone (TSH), triiodothyronine (T3), thyroxine (T4) and cortisol have been measured in 50 patients with duodenal ulcer. The determinations were repeated after a specific time of treatment with ranitidine: in 45 patients after 3 weeks and in 37 after additional 30 days of trea...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:Secondary hyperparathyroidism (sHPT) is one of the most common abnormalities found in patients with chronic kidney disease (CKD). Measurement of serum PTH concentrations is crucial in diagnosis and treatment of sHPT. Different methods of serum PTH measurement may provide diverse results. This may have a si...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0028
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Adrenal pheochromocytoma are diagnosed the most often in patients with arterial hypertension or with thyroid medullar cancer and suspicion of MEN II syndromes. The aim of the study is to analyse the morphology of pheochromocytomas on the basis of Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) in o...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:The aim of immunohistochemistry and immunocytochemistry is to reveal specific antigens in cells and tissue samples. Those techniques are based on an antigen-antibody reaction and visualization of its product in microscopic examination. The precursor of this new diagnostic procedure was an immunofluorescent reaction in...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-05-01 00:00:00
abstract：:Słowo wstępne do "Endokrynologia Polska" 69 (6) 2018. ...
journal_title：Endokrynologia Polska
pub_type： 信件
doi：
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Oxytocin might be used therapeutically as an ally to rescue osteopathy resulting from diabetes. However, the in vivo effects of oxytocin on marrow adipogenesis in diabetes remain unknown. In this longitudinal study, we aimed to investigate the protective ef-fects of oxytocin on diabetes-induced marrow adip...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2018.0040
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:The activity of androgen receptor (AR) is modulated by a polymorphic region located within exon 1 its gene and characterizing a variable number of trinucleotide CAG repeats. The length of polymorphic region is inversely correlated with the transactivation function of AR gene. It was showed an ethnic differen...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:We evaluated the predictive value of IGF-1 against hGH in the treatment outcome. MATERIAL AND METHODS:A prospective study was undertaken of 47 patients (mean age 41.1 ± 12.9 years; 44 with macroadenoma and 3 with microadenoma), requiring treatment with octreotide LAR (SSLAR) following incomplete surgery. Co...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:In view of the fact that primary aldosteronism (PA) is a problem that is more prevalent than previously thought and its diagnosis is of greater clinical significance than previously believed, the Endocrine Society has recently published recommendations on the diagnosis and management of PA. Due to the fact that the cu...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Children's obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high ra...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：INTRODUCTION:An increased risk of mortality in patients with uncontrolled acromegaly has been reported in several studies. We aimed to assess the impact of co-morbidities on the survival of patients with acromegaly after long-term treatment and follow-up. MATERIAL AND METHODS:A retrospective analysis was performed for...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2016.0031
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:In this study, we aimed to investigate the relationship between glycated haemoglobin (HbA1c) levels and the severity of coronary artery disease (CAD) in < 40 years old patients. MATERIAL AND METHODS:The study population consisted of 211 premature coronary atherosclerotic patients (pCAP) (aged 36.4 ± 2.5 y...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Surgeries that spare the adrenal cortex during adrenalectomy have profound justification. Indications for this type of surgery are fairly strict, and more than 30 years of observations continuously verify the results of the procedure. MATERIAL AND METHODS:Of a total of 650 adrenalectomies, 22 (3.4%) were ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0033
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:The overexpression of nitric oxide synthase (NOS) has been found in tumours, including pituitary adenomas. It has also been found that NOS is overexpressed in human spontaneous pituitary adenomas. The question arises whether NOS and its product, nitric oxide (NO), are involved in pituitary tumourigenesis. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Hypocalcemic response following the administration of 160 units of porcine calcitonin was investigated in 14 patients with bone lesions caused by myeloma and in 9 control subjects. Significant decrease in blood serum calcium level was found in 85 per cent of myeloma patients, both in those with osteolytic bone lesions...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Ig-G4 related disease (IgG4RD) is a heterogeneous disorder with multi-organ involvement recognised as a separate entity at the start of this century only. It is currently one of the hottest areas of clinical and translational research across specialties. Thyroid involvement in IgG4RD is rare, believed to occur in less...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2016.0061
更新日期：2016-01-01 00:00:00
abstract：:There is a growing number of diseases which prevalence can be associated with vitamin D deficiency. The link between low cholecalciferol concentration and bone diseases is well established, however there is also data suggesting that it may influence development and progression of different cancers and autoimmune disea...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2007-03-01 00:00:00
abstract：:The treatment of Graves' orbitopathy (GO) remains a diagnostic and therapeutic challenge for clinicians worldwide. The elimination of risk factors, such as encouraging smoking cessation and achieving euthyroidism, are the most important and usually sufficient treatment methods in most mild cases. A course of selenium ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2014.0054
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:Aim of the study was present personal observations connected with the management of patients referred to surgical treatment for secondary hyperparathyroidism (SHT) or tertiary hyperparathyroidism (THT), and to assess immediate results of such management. MATERIAL AND METHODS:A total of 175 patients aged 2...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：INTRODUCTION:Hypolipidaemic agents were found to affect plasma adipokine levels, but no previous study has investigated whether this effect is sex-dependent. MATERIAL AND METHODS:We retrospectively analysed 61 patients participating in our previous studies, who because of isolated hypercholesterolaemia were treated wi...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0017
更新日期：2015-01-01 00:00:00
abstract：:Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：INTRODUCTION:Growth hormone (GH) deficiency, either isolated or combined with other pituitary hormone deficiencies, is associated with increased mortality and abnormal body composition, particularly visceral adiposity. We aimed to investigate the effects of GH deficiency with or without sex steroid deficiencies on ultr...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0027
更新日期：2014-01-01 00:00:00
abstract：:A case of rare association of hyperparathyroidism with fully developed hyperthyroidism appearing in a woman 23 years old with advanced generalized cystic fibrosis has been presented. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The clinical manifestation of oncogenic osteomalacia includes bone pain, pathological fractures, general fatigue and muscle weakness. Such unspecific symptoms hinder the establishment of a proper diagnosis which very often requires long-lasting investigations with many diagnostic imaging methods. Here, we discuss di...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
