Abstract：
INTRODUCTION:Recently, a new fracture risk-assessment calculator (FRAX) has been introduced. The aim of this study was to assess its usefulness for the re-assessment of fracture risk in obese patients and re-assignment to treatment. MATERIAL AND METHODS:350 obese female patients were included. In all of them, 10-year fracture risk was calculated using FRAX (with and without T score value). RESULTS:If major osteoporotic fracture risk was calculated with BMD, it was low in most of the patients (in 82.1% of those treated, and in 95.9% of those not treated it was below 10%). Mean risk values were significantly higher in the treated (7.7 [3;39]%) than in the non-treated group (4.6 [2.1;14]%). The reason for start of treatment in 95 out of 106 patients was a sustained low-energy fracture, low BMD, or both. CONCLUSIONS:The WHO fracture risk calculator may be a useful tool in treated obese females with osteoporosis. The information regarding 10-year fracture risk may change the treatment strategy at least for those in whom the decision of treatment was based solely on low BMD.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Franek E,Wichrowska H,Gozdowski D,Puzianowska-Kuźnicka Msubject
Has Abstractpub_date
2009-03-01 00:00:00pages
82-7issue
2eissn
0423-104Xissn
2299-8306journal_volume
60pub_type
杂志文章abstract：:In our study we present chosen elements of microarray analysis of gene expression profile in papillary thyroid cancer. The study group included 16 papillary thyroid cancer tissues and 16 corresponding normal tissues. Samples were analyzed on high density oligonucleotide microarrays (GeneChip HG-U133A) which contain 22...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：INTRODUCTION:Calcitonin gene-related peptide is an important vasodilator. It plays an important role in the metabolism of chewing muscles. The aim of the study was to evaluate the plasma level of CGRP in patients with myofascial pain (RDC/TMD Ia) and myofascial pain with limited opening (RDC/TMD Ib) before and after oc...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,随机对照试验
doi：10.5603/EP.2017.0025
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, it seems that it is necessary to investigate the aetiology of the disorder and its related factors. The aim of this study was to determine the aetiology of CH among children in Isfahan province. MATERIAL AND METHODS:In this cros...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Adrenal pheochromocytoma are diagnosed the most often in patients with arterial hypertension or with thyroid medullar cancer and suspicion of MEN II syndromes. The aim of the study is to analyse the morphology of pheochromocytomas on the basis of Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) in o...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:Most medical agents currently applied in osteoporosis therapy act by inhibiting bone resorption and reducing bone remodelling, i.e. they inhibit the process of bone mass loss by suppressing bone resorption processes. These drugs provide an ideal therapeutic option to prevent osteoporosis progression. They however have...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Increased interest in vitamin D measurements in clinical studies has contributed to the development in recent years of several new immunochemical assays (manual and for automatic analyzers). New methods, including HPLC (high performance liquid chromatography), and LC-MS/MS (liquid chromatography coupled with tandem ma...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：:Thyroid cancer in children is rare and accounts for 1-3% of all malignant tumours. Differentiated thyroid cancers (DTC) and particularly papillary thyroid carcinoma (PTC) (90% of cases) are the most prevalent. Surgery is the mainstay of treatment in patients with DTC. The current recommendations are based not on prosp...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.a2019.0033
更新日期：2019-01-01 00:00:00
abstract：:We present a case of a woman with unique multisystem disorder--POEMS syndrome and endocrine abnormalities coexisting with it. The POEMS acronym comprises the dominant features: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M protein), skin changes. Association between plasma cell dyscrasia and poly...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:Since the effect of pre-therapeutic scintigraphy on the outcome of DTC treatment is debated, we evaluated factors affecting the effectiveness of (131)I therapy with respect to the delay between diagnostic scintigraphy and the application of radioiodine. MATERIAL AND METHODS:In the studied group of 60 pati...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：:Cushing's disease (CD) is caused by an adrenocorticotrophin (ACTH) secreting pituitary adenoma and it is the commonest cause of endogenous hypercortisolism. When high suspicion of Cushing's syndrome (CS) exists, recommended screening tests include the overnight dexamethasone suppression test, the low-dose dexamethason...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve breathing function in PWS, but the findings are not explicit. MATERIAL AND METHODS:Screening polysomnography- polygraphy (PSG...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0057
更新日期：2017-01-01 00:00:00
abstract：:Osteoporosis is a chronic disease of the osseous system characterised by decreased strength of bone tissue, which in turn leads to increased fracture risk. It has been demonstrated that osteoporosis affects more than 30% of women after the menopause (WHO, 1994). However, the disease is also observed in men. The primar...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:Patients with hypogonadism are at increased risk of cardiac and metabolic diseases and osteoporosis. Vitamin D and Fibroblast growth factor-23 (FGF-23) play role in the regulation of bone mineral metabolism and endothelial functions. Low vitamin D levels are reported in hypogonadism, while there is no data...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0009
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content. MATERIAL AND METHODS:We studied two age-, we...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0013
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seld...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.a2018.0010
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. MATERIAL AND METHODS:Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 year...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2017.0046
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Despite the known importance of somatostatin analogues (SSAs) in the treatment of acromegaly, patient satisfaction leading to preferences for specific SSAs have received little attention so far. MATERIAL AND METHODS:This open, prospective, observational, multicentre patient-reported outcome study included...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,多中心研究
doi：10.5603/EP.2016.0066
更新日期：2016-01-01 00:00:00
abstract：:The effect of cholecystokinin octapeptide (CCK-8) on basal and TRH-stimulated secretion of TSH was investigated in 67 male Sprague-Dawley rats. Blood for TSH determinations was sampled by cannulation of right heart auricle in urethane narcosis before and four times during 60 minutes following CCK-8 administration. It ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Obesity and thyroid function are closely related. Thyroid hormones are involved in the regulation of metabolism, thermogenesis, food intake, and fat oxidation. In obese children the most frequent hormonal abnormalities are slight hyperthyrotropinaemia and moderate increases in total T3 and/or fT3 concentrations. Those...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2017.0007
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to evaluate the influence of body mass changes on plasma concentrations of proinflammatory cytokines in obese women after the initially obtained weight reduction in a five-year follow-up period. MATERIAL AND METHODS:Thirty out of 42 women with simple obesity (age 41.8 ± 11.9 year...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Autoimmune polyglandular syndromes (APS) consist of a variety of endocrine and non-endocrine disorders. The syndromes are complex and their occurrence in life does not follow any pattern. Early detection of such disorders may prevent many serious clinical consequences which are usually a result of delayed diagnosis. W...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0070
更新日期：2014-01-01 00:00:00
abstract：:There is a growing number of diseases which prevalence can be associated with vitamin D deficiency. The link between low cholecalciferol concentration and bone diseases is well established, however there is also data suggesting that it may influence development and progression of different cancers and autoimmune disea...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2007-03-01 00:00:00
abstract：INTRODUCTION:Meteorin-like (Metrnl), also known as subfatin, is a recently discovered adipokine with a favourable effect on insulin sensitivity. Studies have shown lower Metrnl levels in obese patients. However, data on its circulating levels in type 2 diabetes mellitus (T2DM) patients are contradictory. This study aim...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0038
更新日期：2020-01-01 00:00:00
abstract：:According to the socio-sexological reports approximately 40-45% of women and up to 30% of males may suffer from different sexual dysfunctions. The prevalence of those disorders is gradually increasing with age. Multiply numbers of endocrinopathies may influence the human sexual life. In diabetic patients all phases of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-11-01 00:00:00
abstract：:The World Health Organization (WHO) issued a recommendation (Technical Consultation: Paris 2006, Luxembourg 2007) that salt consumption, as a risk factor for hypertension, atherosclerosis, myocardial infarction, stroke, and select cancers, should be restricted. The European Commission looked to adhere to this recommen...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:The paper presents actual data concerning osteoporotic fractures (definitions, causes, epidemiologic and clinical data, consequences, treatment) particulary data about the most common fractures (distal forearm, vertebral and proximal hip fractures). ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2009-11-01 00:00:00
abstract：:The clinical manifestation of oncogenic osteomalacia includes bone pain, pathological fractures, general fatigue and muscle weakness. Such unspecific symptoms hinder the establishment of a proper diagnosis which very often requires long-lasting investigations with many diagnostic imaging methods. Here, we discuss di...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Oxytocin might be used therapeutically as an ally to rescue osteopathy resulting from diabetes. However, the in vivo effects of oxytocin on marrow adipogenesis in diabetes remain unknown. In this longitudinal study, we aimed to investigate the protective ef-fects of oxytocin on diabetes-induced marrow adip...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2018.0040
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:Thyroid dysgenesis (TD) is the main cause of congenital hypothyroidism (CH), affecting nearly 1 in 2000-3000 newborns worldwide, as the most common neonatal endocrine disorder. Paired box gene 8 (PAX8), expressed during all stages of thyroid follicular cell, plays a key role in thyroid morphogenesis by a c...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0004
更新日期：2020-01-01 00:00:00
