Abstract:
:Autoimmune polyglandular syndromes (APS) consist of a variety of endocrine and non-endocrine disorders. The syndromes are complex and their occurrence in life does not follow any pattern. Early detection of such disorders may prevent many serious clinical consequences which are usually a result of delayed diagnosis. We present the case of a female patient whose clinical symptoms very strongly suggested APS, however neither autoimmune background except elevated anti-thyroid peroxidase and anti-thyroglobulin antibodies of multiglandular deficiency, nor critical mutations in the AIRE gene have been confirmed or detected, yet we identified five polymorphisms and two mutations in exon1 of gene AIRE during 12 years of observation and treatment.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Barg E,Skarżynska M,Pollak A,Ślęzak R,Głąb E,Petriczko E,Józwa A,Sąsiadek MMdoi
10.5603/EP.2014.0070subject
Has Abstractpub_date
2014-01-01 00:00:00pages
514-8issue
6eissn
0423-104Xissn
2299-8306pii
VM/OJS/J/40645journal_volume
65pub_type
杂志文章abstract::There is a growing number of diseases which prevalence can be associated with vitamin D deficiency. The link between low cholecalciferol concentration and bone diseases is well established, however there is also data suggesting that it may influence development and progression of different cancers and autoimmune disea...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2007-03-01 00:00:00
abstract:INTRODUCTION:Generally, squamous cell carcinoma carries a poor prognosis because of its tendency to local invasion and subsequent metastasis, which is mediated by multiple factors and angiogenesis. Hepatocyte growth factor (HGF) is a potent mitogen for epithelial cells and regulates cell proliferation and migration and...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::The basic data on hyperprolactinemia (i.e. an excess of PRL above a reference laboratory's upper limits), the most common endocrine disorder of the hypothalamic-pituitary axis are given in this review. The following issues are discussed: regulation of prolactin (Prl) secretion, definition of hyperprolactinemia, its et...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Tumor induced osteomalacia (TIO) are extremely rare paraneoplastic syndrome with less than 300 reported cases. This report highlights the pitfalls and challenges in diagnosing and localizing TIO in patients with refractory and resistant osteomalacia. PATIENT AND METHODS:41- year gentleman with 4-year histor...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2018.0016
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Over the last decade, average life expectancy has continuously increased. There has been no data on normal sex hormone (SH) levels in a Polish elderly population. In this study, we assessed SH in the PolSenior cohort to determine normal reference ranges in relation to gender, age, and cardiovascular diseas...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The introduction of the DICOM format in all diagnostic imaging devices allowed co-registering SPECT, CT, MR and other types of biomedical imaging. Fusion can be performed by dedicated hybrid devices or by means of software. The fusion algorithm consists of two steps: coregistration and simultaneous visuali...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:An increased risk of mortality in patients with uncontrolled acromegaly has been reported in several studies. We aimed to assess the impact of co-morbidities on the survival of patients with acromegaly after long-term treatment and follow-up. MATERIAL AND METHODS:A retrospective analysis was performed for...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2016.0031
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Calcitonin gene-related peptide is an important vasodilator. It plays an important role in the metabolism of chewing muscles. The aim of the study was to evaluate the plasma level of CGRP in patients with myofascial pain (RDC/TMD Ia) and myofascial pain with limited opening (RDC/TMD Ib) before and after oc...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,随机对照试验
doi:10.5603/EP.2017.0025
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Thyroid dysgenesis (TD) is the main cause of congenital hypothyroidism (CH), affecting nearly 1 in 2000-3000 newborns worldwide, as the most common neonatal endocrine disorder. Paired box gene 8 (PAX8), expressed during all stages of thyroid follicular cell, plays a key role in thyroid morphogenesis by a c...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0004
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Childhood obesity has been associated with the development of insulin resistance, potentially leading to several metabolic disorders. Osteocalcin has been reported to contribute to the regulation of glucose tolerance and insulin sensitivity. The purpose of this study was to examine the relationship between...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2013.0016
更新日期:2013-01-01 00:00:00
abstract::A case of 55 years old woman with "hot" right lobe toxic thyroid nodule, presenting with paroxysmal atrial fibrillation, and therefore treated with 131I 666MBq (18 mCi) is described. After six years she became pyrexic and suffered of severe cough proxyisms. The fine needle biopsy of the above nodule showed the presenc...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content. MATERIAL AND METHODS:We studied two age-, we...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2019.0013
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Adrenal pheochromocytoma are diagnosed the most often in patients with arterial hypertension or with thyroid medullar cancer and suspicion of MEN II syndromes. The aim of the study is to analyse the morphology of pheochromocytomas on the basis of Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) in o...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract::A group of 153 patients with scintigraphically detected autonomic "hot" nodules of the thyroid has been subjected to clinical and histopathological analysis. Substantial part of these patients (30.1%) had hyperthyroidism, partly (in 19.9% of cases) in the form of the thyrocardiac syndrome. A most frequent histopatholo...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of the malignant neoplasms of the thyroid gland. ATC usually manifests itself with the local symptoms due to a rapidly enlarging thyroid mass, and as other thyroid cancers, has only seld...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:10.5603/EP.a2018.0010
更新日期:2018-01-01 00:00:00
abstract::Thyroid disorders are more frequently observed in diabetic patients. These conditions have been shown to be mainly of autoimmune origin and all of them may lead to hormonal imbalance. Especially strong links exist between autoimmune thyroid diseases (AITD) and type 1 diabetes. Importantly, both hypothyroidism and hype...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,实务指引
doi:
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Omentin-1, secreted by visceral adipose tissue, has been indicated in the regulation of bone metabolism in girls with anorexia nervosa (AN). The aim of the study was to evaluate the relationship between omentin-1 and bone metabolism in girls with AN as well as the potential involvement of OPG and RANKL in ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2015.0063
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Surgery remains the most effective treatment for primary hyperparathyroidism (PHPT). Minimally invasive radioguided parathyroidectomy (MIRP) is a common technique for detecting and excising abnormal parathyroid glands. The aim of this study was to compare injections of low-dose and high-dose (99m) Tc metho...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2017.0031
更新日期:2017-01-01 00:00:00
abstract::Acromegaly is usually caused by excess GH (growth hormone) secretion by pituitary adenoma. Extremely rare (< 1% of cases) acromegaly can be a result of ectopic GHRH (growth hormone releasing hormone) secretion by bronchial tubes, lung, pancreatic or intestinal tumor. The aim of this description is to present the case ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Follicular Lesion of Undetermined Significance (FLUS) belongs to the most controversial category of the Bethesda System. The aim of the study was to specify the risk of malignancy in patients with FLUS diagnosis in the material from the Institute of Oncology in Gliwice. This is the first Polish study speci...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.2016.0002
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS:mRNA expression of adipokines;...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2018.0091
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Estimation of malignancy in thyroid follicular neoplasms is a common diagnostic problem, thus revealing of differences in expression of some antigens in both benign and malignant lesions seems to be essential. The aim of this study is to evaluate the immunohistochemical expression of CD15, galectin-3 and H...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract:INTRODUCTION:Fine needle aspiration biopsy (FNAB) of the thyroid nodules generally allows to make the diagnosis and to choose the proper clinical management. In about 10% of cases cytopathologic features do not differentiate unequivocally benign and malignant lesions. In these cases the cytopathologic diagnosis of foll...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Bone disorders observed commonly after haematopoietic stem cells transplantation (HSCT) can be caused by several factors,but their detailed pathomechanism is still not well known, especially in childhood.The aim of this study was to evaluate: IGF-I, RANKL-OPG system, IL-6, and IL1β levels and their associa...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/ep.2013.0001
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The exact aetiology is unknown. However, genetic and environmental factors are suggested to be involved in the pathogenesis of MS. Improper diet, resulting in obesity and metabolic syndrome, can contribute to this disease. Adip...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2020.0008
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:In order to be effective, treatment for osteoporosis must be long-term. Unfortunately, according to clinical trials and clinical practice the most frequent cause of patient resignation from the treatment is adverse reactions to the medications. In the case of bisphosphonates they are most frequently connec...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The present study aims to evaluate the incidence, types, timing and risk factors in amiodarone (AMD)-induced thyroid dysfunction. MATERIAL AND METHODS:The study comprised 229 patients from an iodine-replete area (115 women, 114 men, mean age 63.8 ± 9.2 years), chronically treated with AMD. The cases were ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve breathing function in PWS, but the findings are not explicit. MATERIAL AND METHODS:Screening polysomnography- polygraphy (PSG...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:10.5603/EP.a2017.0057
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Patients with Addison's disease experience many somatic and psychic changes, which decrease their quality of life. The aim of the study was to evaluate the "psychological equipment" of these patients to cope with stress connected with this chronic disease and the challenge of constant treatment. MATERIAL ...
journal_title:Endokrynologia Polska
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Thyroid cancer in children is rare and accounts for 1-3% of all malignant tumours. Differentiated thyroid cancers (DTC) and particularly papillary thyroid carcinoma (PTC) (90% of cases) are the most prevalent. Surgery is the mainstay of treatment in patients with DTC. The current recommendations are based not on prosp...
journal_title:Endokrynologia Polska
pub_type: 杂志文章,评审
doi:10.5603/EP.a2019.0033
更新日期:2019-01-01 00:00:00