Abstract：
INTRODUCTION:In order to be effective, treatment for osteoporosis must be long-term. Unfortunately, according to clinical trials and clinical practice the most frequent cause of patient resignation from the treatment is adverse reactions to the medications. In the case of bisphosphonates they are most frequently connected with irritant impact of the drug on gastrointestinal mucosa. The aim of our study was to answer the question whether alendronate tablets coated with a thin neutral layer may protect gastrointestinal mucosa from the irritant effects of the active substance. MATERIAL AND METHODS:Three types of tablets were administered into the cheek pouches of 18 Syrian hamsters (divided into 3 experimental groups: I, II, III) i.e. regular alendronate tablets, coated alendronate tablets and placebo. The tablets were applied for 4 minutes a day on 4 consecutive days. 24 hours after the last application, the animals were sacrificed and segments of buccal tissue were taken for histopathological examination. Oral tissue reaction was assessed using the microscopic examination grading system developed by ISO. The following adverse changes of the tissue were recorded: epithelial lesions, leucocyte infiltration, vascular congestion and oedema. Later the irritation index was calculated. RESULTS:The irritation index was 11.0 (moderately irritant), 0.0 and 0.0 (none-irritant), in each group respectively. CONCLUSION:It appears that the administration of the coated alendronate tablets reduces the frequency and intensity of the local adverse events from the gastrointestinal tract.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Jastrzebski Z,Napiórkowska L,Pykało Rsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
11-7issue
1eissn
0423-104Xissn
2299-8306journal_volume
58pub_type
杂志文章abstract：:Increased interest in vitamin D measurements in clinical studies has contributed to the development in recent years of several new immunochemical assays (manual and for automatic analyzers). New methods, including HPLC (high performance liquid chromatography), and LC-MS/MS (liquid chromatography coupled with tandem ma...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：:Obesity and thyroid function are closely related. Thyroid hormones are involved in the regulation of metabolism, thermogenesis, food intake, and fat oxidation. In obese children the most frequent hormonal abnormalities are slight hyperthyrotropinaemia and moderate increases in total T3 and/or fT3 concentrations. Those...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2017.0007
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Hypolipidaemic agents were found to affect plasma adipokine levels, but no previous study has investigated whether this effect is sex-dependent. MATERIAL AND METHODS:We retrospectively analysed 61 patients participating in our previous studies, who because of isolated hypercholesterolaemia were treated wi...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0017
更新日期：2015-01-01 00:00:00
abstract：:We present a case of a woman with unique multisystem disorder--POEMS syndrome and endocrine abnormalities coexisting with it. The POEMS acronym comprises the dominant features: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M protein), skin changes. Association between plasma cell dyscrasia and poly...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：:The paper concerns osteonecrosis of the jaw (ONJ). It is a rare but serious clinical condition. It can develop in patients treated in oncologic doses with bisphosphonates but also with denosumab. In osteoporosis ONJ seems to be very rare. Definition, pathogenesis, risk factors, prevention and treatment, and the freque...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:The study was aimed at the assessment of frequency of occurrence of thyroid antimicrosomal and antithyreoglobuln autoantibodies in children with insulin-dependent diabetes and healthy control children. The occurrence of thyroid autoantibodies was analyzed with respect to the age and sex of children and the duration of...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The treatment of Graves' orbitopathy (GO) remains a diagnostic and therapeutic challenge for clinicians worldwide. The elimination of risk factors, such as encouraging smoking cessation and achieving euthyroidism, are the most important and usually sufficient treatment methods in most mild cases. A course of selenium ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/EP.2014.0054
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:Bone disorders observed commonly after haematopoietic stem cells transplantation (HSCT) can be caused by several factors,but their detailed pathomechanism is still not well known, especially in childhood.The aim of this study was to evaluate: IGF-I, RANKL-OPG system, IL-6, and IL1β levels and their associa...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/ep.2013.0001
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:The activity of androgen receptor (AR) is modulated by a polymorphic region located within exon 1 its gene and characterizing a variable number of trinucleotide CAG repeats. The length of polymorphic region is inversely correlated with the transactivation function of AR gene. It was showed an ethnic differen...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：INTRODUCTION:The present study aims to evaluate the incidence, types, timing and risk factors in amiodarone (AMD)-induced thyroid dysfunction. MATERIAL AND METHODS:The study comprised 229 patients from an iodine-replete area (115 women, 114 men, mean age 63.8 ± 9.2 years), chronically treated with AMD. The cases were ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Not required for Clinical Vignette. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0071
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Meteorin-like (Metrnl), also known as subfatin, is a recently discovered adipokine with a favourable effect on insulin sensitivity. Studies have shown lower Metrnl levels in obese patients. However, data on its circulating levels in type 2 diabetes mellitus (T2DM) patients are contradictory. This study aim...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0038
更新日期：2020-01-01 00:00:00
abstract：:A group of 153 patients with scintigraphically detected autonomic "hot" nodules of the thyroid has been subjected to clinical and histopathological analysis. Substantial part of these patients (30.1%) had hyperthyroidism, partly (in 19.9% of cases) in the form of the thyrocardiac syndrome. A most frequent histopatholo...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:We describe a 37 year-old woman case of latent autoimmune diabetes in adults (LADA). She was presented with unfounded weight loss. The diagnosis of diabetes mellitus was established on twice plasma glucose measurements above 200 mg/dl. In other routine biochemical examinations we did not observe dehydratation, electro...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：INTRODUCTION:Fine needle aspiration biopsy (FNAB) is the main examination in diagnostics of thyroid nodules. Yet, it does not allow the differentiation of follicular lesions (FL). A new classification of thyroid biopsy results (newC) might improve pre-operative diagnostics mainly due to the introduction of a new subcat...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2014.0060
更新日期：2014-01-01 00:00:00
abstract：:Osteoporosis is a chronic disease of the osseous system characterised by decreased strength of bone tissue, which in turn leads to increased fracture risk. It has been demonstrated that osteoporosis affects more than 30% of women after the menopause (WHO, 1994). However, the disease is also observed in men. The primar...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Not required for Clinical Vignette. ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0045
更新日期：2020-01-01 00:00:00
abstract：:Primary aldosteronism is the commonest form of hormone-related hypertension, with an estimated prevalence of 6-13% in the generalpopulation of hypertensive patients. Among patients with resistant hypertension, the proportion of PA is even higher. Through intensiveresearch in the field of basic science and the creation...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：10.5603/ep.2013.0011
更新日期：2013-01-01 00:00:00
abstract：INTRODUCTION:Patients with Addison's disease experience many somatic and psychic changes, which decrease their quality of life. The aim of the study was to evaluate the "psychological equipment" of these patients to cope with stress connected with this chronic disease and the challenge of constant treatment. MATERIAL ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:The hormone leptin is secreted from white adipocytes, and serum levels of leptin correlate with adipose tissue mass. Leptin was first described as acting on the satiety centre in the hypothalamus through specific receptors (ob-R) to restrict food intake and enhance energy expenditure. Leptin plays a crucial role in th...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:Follicular Lesion of Undetermined Significance (FLUS) belongs to the most controversial category of the Bethesda System. The aim of the study was to specify the risk of malignancy in patients with FLUS diagnosis in the material from the Institute of Oncology in Gliwice. This is the first Polish study speci...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2016.0002
更新日期：2016-01-01 00:00:00
abstract：:Renalase is a recently identified flavoprotein oxidase, secreted mainly by the kidneys, which takes part in the degradation of catecholamines. The catecholamine inactivating effect results in the modulation of the sympathetic system tension and, consequently, in a decrease of blood pressure, myocardial contractility, ...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2020.0044
更新日期：2020-01-01 00:00:00
abstract：:One severe aplastic anaemia case who presented autoimmune thyroid disease after allogeneic bone marrow transplantation (alloBMT) is described. A 19 year old Polish girl developed Graves' hyperthyroidisms 19 months after allogeneic BMT for severe aplastic anaemia (SAA) donated from her brother. Her serum was positive f...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:The World Health Organization (WHO) issued a recommendation (Technical Consultation: Paris 2006, Luxembourg 2007) that salt consumption, as a risk factor for hypertension, atherosclerosis, myocardial infarction, stroke, and select cancers, should be restricted. The European Commission looked to adhere to this recommen...
journal_title：Endokrynologia Polska
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:We present the diagnostic and therapeutic difficulties encountered in a patient with a clinically advanced pancreatic neuroendocrine tumour. The report concerns a 60-year-old female patient with the diagnosis of non-functioning pancreatic neuroendocrine tumour (NET G1) with liver, peripancreatic lymph node and mediast...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:The study, supported by program MZ-XVII, was carried on 4567 inhabitants of the area of Szczecin (2350 females and 2217 males). The population was chosen randomly, according to a simple drawing scheme. All subjects were clinically examined using standardised questionnaires. In 3468 persons (including 1807 girls and wo...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:We evaluated the predictive value of IGF-1 against hGH in the treatment outcome. MATERIAL AND METHODS:A prospective study was undertaken of 47 patients (mean age 41.1 ± 12.9 years; 44 with macroadenoma and 3 with microadenoma), requiring treatment with octreotide LAR (SSLAR) following incomplete surgery. Co...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:Secondary hyperparathyroidism (sHPT) is one of the most common abnormalities found in patients with chronic kidney disease (CKD). Measurement of serum PTH concentrations is crucial in diagnosis and treatment of sHPT. Different methods of serum PTH measurement may provide diverse results. This may have a si...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.2015.0028
更新日期：2015-01-01 00:00:00
abstract：INTRODUCTION:The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content. MATERIAL AND METHODS:We studied two age-, we...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：10.5603/EP.a2019.0013
更新日期：2019-01-01 00:00:00
abstract：:Blood serum concentrations of thyrotropic hormone (TSH), triiodothyronine (T3), thyroxine (T4) and cortisol have been measured in 50 patients with duodenal ulcer. The determinations were repeated after a specific time of treatment with ranitidine: in 45 patients after 3 weeks and in 37 after additional 30 days of trea...
journal_title：Endokrynologia Polska
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
