Abstract：
INTRODUCTION:In Romania, there is no acromegaly national register and there are no nationwide data available. However, some studies have reported the control rates in the country's main referral centres. Our aim was to assess the overall control rate in our tertiary referral centre. Also, we assessed the control rate in the last three years, and we compared the results with our previous reports. MATERIAL AND METHODS:We reviewed the charts of 186 patients with acromegaly assessed in our department between January 1st, 2012 and May 31st, 2019. We also compared the control rates for patients treated between April 1st, 2016 and May 31st, 2019 with historical controls (assessed between January 1st, 2012 and March 31st, 2016). RESULTS:Primary analysis: There were 19 untreated and 167 treated patients, mean age 52.46 years, surgery being the most commonly used treatment. The surgical cure rate was 14.8%, and disease control with medical treatment was 35.3%. Secondary analysis: In the first group there were 45 patients, surgery also being the most commonly used treatment. The surgical cure rate was 26.9%, and disease control was 30.4%. In the second group (historical controls) there were 42 patients, surgery being the most commonly used treatment. The surgical cure rate was 9.7%, and disease control with medical treatment was 15.4%. Random GH and IGF-1 after surgery were lower in the first group (p < 0.05) CONCLUSIONS: Changes in the Romanian protocol and highly specialised pituitary centres has improved the cure rate and disease control in patients with acromegaly.
journal_name
Endokrynol Poljournal_title
Endokrynologia Polskaauthors
Marinescu MC,Baciu I,Baculescu N,Capatina CA,Dusceac R,Galoiu S,Niculescu DA,Radian S,Trifanescu RA,Baleanu MC,Caragheorgheopol A,Poiana Cdoi
10.5603/EP.a2020.0020subject
Has Abstractpub_date
2020-01-01 00:00:00pages
235-239issue
3eissn
0423-104Xissn
2299-8306pii
VM/OJS/J/67206journal_volume
71pub_type
杂志文章abstract：:Cushing's disease (CD) is caused by an adrenocorticotrophin (ACTH) secreting pituitary adenoma and it is the commonest cause of endogenous hypercortisolism. When high suspicion of Cushing's syndrome (CS) exists, recommended screening tests include the overnight dexamethasone suppression test, the low-dose dexamethason...
journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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更新日期：2013-01-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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更新日期：2005-09-01 00:00:00
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journal_title：Endokrynologia Polska
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journal_title：Endokrynologia Polska
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