In situ UV-crosslinking gelatin electrospun fibers for tissue engineering applications.

abstract：:Despite the widespread use as platforms for various biomedical applications, engineering hydrogels to impart multifunctionality and control physical properties, while closely mimicking the native cellular microenvironment, is still a significant challenge. Herein, nanofibers consisting of hydrophilic and photocrosslin...

journal_title：Biofabrication

authors： Kim S,Cha C

更新日期：2019-12-19 00:00:00

abstract：:An engineered three-dimensional scaffold with hierarchical porosity and multiple niche microenvironments is produced using a combined multi-nozzle deposition-freeze casting technique. In this paper we present a process to fabricate a scaffold with improved interconnectivity and hierarchical porosity. The scaffold is p...

journal_title：Biofabrication

authors： Snyder JE,Hunger PM,Wang C,Hamid Q,Wegst UG,Sun W

更新日期：2014-03-01 00:00:00

abstract：:Calcium alginate hydrogels are widely used as biocompatible materials in a substantial number of biomedical applications. This paper reports on a hybrid 3D printing and electrodeposition approach for forming 3D calcium alginate hydrogels in a controllable manner. Firstly, a specific 3D hydrogel printing system is deve...

journal_title：Biofabrication

authors： Shang W,Liu Y,Wan W,Hu C,Liu Z,Wong CT,Fukuda T,Shen Y

更新日期：2017-06-07 00:00:00

abstract：:The tumour microenvironment is heterogeneous and consists of multiple cell types, variable extracellular matrix (ECM) composition, and contains cell-defined gradients of small molecules, oxygen, nutrients and waste. Emerging in vitro cell culture systems that attempt to replicate these features often fail to incorpora...

journal_title：Biofabrication

authors： Rodenhizer D,Cojocari D,Wouters BG,McGuigan AP

更新日期：2016-10-18 00:00:00

abstract：:Cell cultures for tissue engineering are traditionally prepared on two-dimensional or three-dimensional scaffolds with simple pores; however, this limits mass transportation, which is necessary for cell viability and function. In this paper, an innovative method is proposed for fabricating porous scaffolds with design...

journal_title：Biofabrication

authors： Liu Y,Li X,Qu X,Zhu L,He J,Zhao Q,Wu W,Li D

更新日期：2012-03-01 00:00:00

abstract：:Plasma treatment is a method to modify the physicochemical properties of biomaterials, which consequently may affect interactions with cells. Based on the rationale that physical cues on the surface of culture substrates and implants, such as surface roughness, have proven to alter cell behaviour, we used electrospinn...

journal_title：Biofabrication

authors： Nandakumar A,Tahmasebi Birgani Z,Santos D,Mentink A,Auffermann N,van der Werf K,Bennink M,Moroni L,van Blitterswijk C,Habibovic P

更新日期：2013-03-01 00:00:00

abstract：:Omentum-based matrices fabricated by decellularization have the potential to serve as autologous scaffolds for tissue engineering. Transplantation of such scaffolds prepared from the patient's own biomaterial may reduce the immunogenic response after transplantation. Recently we reported on the potential of the decell...

journal_title：Biofabrication

authors： Soffer-Tsur N,Shevach M,Shapira A,Peer D,Dvir T

更新日期：2014-09-01 00:00:00

abstract：:The aim of this study was to comparatively evaluate the angiogenic capacity of cocultures using either human bone marrow- or human adipose tissue-derived mesenchymal stem cells (MSCs) (BM- or AT-MSCs) with human umbilical vein endothelial cells (HUVECs) both in vitro and in vivo at early time points (i.e. days 3 and 7...

journal_title：Biofabrication

authors： Ma J,Yang F,Both SK,Prins HJ,Helder MN,Pan J,Cui FZ,Jansen JA,van den Beucken JJ

更新日期：2014-03-01 00:00:00

abstract：:As an alternative to conventional cell culture and animal testing, an organ-on-a-chip is applied to study the biological phenomena of organ development and disease, as well as the interactions between human tissues and external stimuli such as chemicals, forces and electricity. The pattern design of a microfluidic cha...

journal_title：Biofabrication

authors： Mao M,He J,Lu Y,Li X,Li T,Zhou W,Li D

更新日期：2018-02-05 00:00:00

abstract：:This paper presents a novel continuous tool-path planning methodology for hollowed scaffold fabrication in tissue engineering. A new functionally gradient porous architecture is proposed with a continuous material deposition planning scheme. A controllable variational pore size and hence the porosity have been achieve...

journal_title：Biofabrication

authors： Khoda AK,Ozbolat IT,Koc B

更新日期：2011-09-01 00:00:00

abstract：:Tissue engineering based on building blocks is an emerging method to fabricate 3D tissue constructs. This method requires depositing and assembling building blocks (cell-laden microgels) at high throughput. The current technologies (e.g., molding and photolithography) to fabricate microgels have throughput challenges ...

journal_title：Biofabrication

authors： Xu F,Moon SJ,Emre AE,Turali ES,Song YS,Hacking SA,Nagatomi J,Demirci U

更新日期：2010-03-01 00:00:00

abstract：:In recent years, novel biofabrication technologies have enabled the rapid manufacture of hydrogel-cell suspensions into tissue-imitating constructs. The development of novel materials for biofabrication still remains a challenge due to a gap between contradicting requirements such as three-dimensional printability and...

journal_title：Biofabrication

authors： Köpf M,Campos DF,Blaeser A,Sen KS,Fischer H

更新日期：2016-05-20 00:00:00

abstract：:In the pharmaceutical industry, new drugs are tested to find appropriate compounds for therapeutic purposes for contemporary diseases. Unfortunately, novel compounds emerge at expensive prices and current target evaluation processes have limited throughput, thus leading to an increase of cost and time for drug develop...

journal_title：Biofabrication

authors： Rodríguez-Dévora JI,Zhang B,Reyna D,Shi ZD,Xu T

更新日期：2012-09-01 00:00:00

abstract：:In clinical islet transplantation, allogeneic islets of Langerhans are transplanted into the portal vein of patients with type 1 diabetes, enabling the restoration of normoglycemia. After intra-hepatic transplantation several factors are involved in the decay in islet mass and function mainly caused by an immediate bl...

journal_title：Biofabrication

authors： Marchioli G,van Gurp L,van Krieken PP,Stamatialis D,Engelse M,van Blitterswijk CA,Karperien MB,de Koning E,Alblas J,Moroni L,van Apeldoorn AA

更新日期：2015-05-28 00:00:00

abstract：:Native small intestine possesses distinct multi-scale structures (e.g., crypts, villi) not included in traditional 2D intestinal culture models for drug delivery and regenerative medicine. The known impact of structure on cell function motivates exploration of the influence of intestinal topography on the phenotype of...

journal_title：Biofabrication

authors： Koppes AN,Kamath M,Pfluger CA,Burkey DD,Dokmeci M,Wang L,Carrier RL

更新日期：2016-08-22 00:00:00

abstract：:A critical consideration in tissue engineering is to recapitulate the microstructural organization of native tissues that is essential to their function. Scaffold-based techniques have focused on achieving this via the contact guidance principle wherein topographical cues offered by scaffold fibers direct migration an...

journal_title：Biofabrication

authors： Chansoria P,Narayanan LK,Schuchard K,Shirwaiker R

更新日期：2019-04-26 00:00:00

abstract：:Advances in three-dimensional cell cultures offer new opportunities in biomedical research and drug development. However, there are still challenges to overcome, including the lack of reliability, repeatability and complexity of tissues obtained by these techniques. In this study, we describe a new bioprinting system ...

journal_title：Biofabrication

authors： da Conceicao Ribeiro R,Pal D,Ferreira AM,Gentile P,Benning M,Dalgarno K

更新日期：2018-12-27 00:00:00

abstract：:Silica-bonded calcite scaffolds have been successfully 3D-printed by direct ink writing, starting from a paste comprising a silicone polymer and calcite powders, calibrated in order to match a SiO2/CaCO3 weight balance of 35/65. The scaffolds, fabricated with two slightly different geometries, were first cross-linked ...

journal_title：Biofabrication

authors： Fiocco L,Elsayed H,Badocco D,Pastore P,Bellucci D,Cannillo V,Detsch R,Boccaccini AR,Bernardo E

更新日期：2017-05-11 00:00:00

abstract：:Cell mechanical microenvironment (CMM) significantly affects cell behaviors such as spreading, migration, proliferation and differentiation. However, most studies on cell response to mechanical stimulation are based on two-dimensional (2D) planar substrates, which cannot mimic native three-dimensional (3D) CMM. Accumu...

journal_title：Biofabrication

authors： Huang G,Wang L,Wang S,Han Y,Wu J,Zhang Q,Xu F,Lu TJ

更新日期：2012-12-01 00:00:00

abstract：:Calcified cartilage regeneration plays an important role in successful osteochondral repair, since it provides a biological and mechanical transition from the unmineralized cartilage at the articulating surface to the underlying mineralized bone. To biomimic native calcified cartilage in engineered constructs, here we...

journal_title：Biofabrication

authors： You F,Chen X,Cooper DML,Chang T,Eames BF

更新日期：2018-12-27 00:00:00

abstract：:We have developed cell sheet technology as a modern method for the fabrication of functional tissue-like and organ-like structures. This technology allows for a sheet of interconnected cells and cells in full contact with their natural extracellular environment to be obtained. A cell sheet can be patterned and compose...

journal_title：Biofabrication

authors： Hannachi IE,Yamato M,Okano T

更新日期：2009-06-01 00:00:00

abstract：:Four-dimensional (4D) bioprinting, encompassing a wide range of disciplines including bioengineering, materials science, chemistry, and computer sciences, is emerging as the next-generation biofabrication technology. By utilizing stimuli-responsive materials and advanced three-dimensional (3D) bioprinting strategies, ...

journal_title：Biofabrication

authors： Li YC,Zhang YS,Akpek A,Shin SR,Khademhosseini A

更新日期：2016-12-02 00:00:00

abstract：:Cell therapy represents a promising option for revascularization of ischemic tissues. However, injection of dispersed cells is not optimal to ensure precise homing into the recipient's vasculature. Implantation of cell-engineered scaffolds around the occluded artery may obviate these limitations. Here, we employed the...

journal_title：Biofabrication

authors： Carrabba M,De Maria C,Oikawa A,Reni C,Rodriguez-Arabaolaza I,Spencer H,Slater S,Avolio E,Dang Z,Spinetti G,Madeddu P,Vozzi G

更新日期：2016-03-24 00:00:00

abstract：:In the body, cells are surrounded by an interconnected mesh of insoluble, bioactive protein fibres to which they adhere in a well-controlled manner, embedded in a hydrogel-like highly hydrated matrix. True morphological and biochemical mimicry of this so-called extracellular matrix (ECM) remains a challenge but appear...

journal_title：Biofabrication

authors： Schulte VA,Hahn K,Dhanasingh A,Heffels KH,Groll J

更新日期：2014-06-01 00:00:00

abstract：:An important unsolved challenge in tissue engineering has been the inability to replicate the geometry and function of vascular networks and blood vessels. Here, we engineer a user-defined 3D microfluidic vascular channel using 3D printing-enabled hydrogel casting. First, a hollow L-shaped channel is developed using a...

journal_title：Biofabrication

authors： Yang L,Shridhar SV,Gerwitz M,Soman P

更新日期：2016-08-26 00:00:00

abstract：:Cardiovascular diseases (CVDs) are considered the principal cause of worldwide death, being atherosclerosis the main etiology. Up to now, the predominant treatment for CVDs has been bypass surgery from autologous source. However, due to previous harvest or the type of disease, this is not always an option. For this re...

journal_title：Biofabrication

authors： Bosch Rué E,Delgado LM,Gil FJ,Perez RA

更新日期：2020-09-30 00:00:00

abstract：:Three-dimensional (3D) tissue models are invaluable tools that can closely reflect the in vivo physiological environment. However, they are usually difficult to develop, have a low throughput and are often costly; limiting their utility to most laboratories. The recent availability of inexpensive additive manufacturin...

journal_title：Biofabrication

authors： Flood P,Alvarez L,Reynaud EG

更新日期：2016-10-11 00:00:00

abstract：:Traditional drug discovery involves the screening of lead compounds from a chemical library by using cell-based high throughput screening (HTS) procedures. This has created a demand for the development of cell-based microarray chips for HTS of compounds. Although several cell-based microarray devices and procedures fo...

journal_title：Biofabrication

authors： Fujita S,Onuki-Nagasaki R,Ikuta K,Hara Y

更新日期：2016-12-05 00:00:00

abstract：:Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal disease burden. Tissue engineering has proposed several strategies comprising the use of biodegradable materials to prepare scaffolds that can present mechanical properties similar to those of native IVD tissues. However, this might...

journal_title：Biofabrication

authors： van Uden S,Silva-Correia J,Correlo VM,Oliveira JM,Reis RL

更新日期：2015-01-21 00:00:00

abstract：:We report on the fabrication of silicon-reinforced carbon (C:Si) structures by combinatorial pulsed laser deposition to search for the best design for a new generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbi...

journal_title：Biofabrication

authors： Mihailescu IN,Bociaga D,Popescu-Pelin G,Stan GE,Duta L,Socol G,Chifiriuc MC,Bleotu C,Lazar V,Husanu MA,Zgura I,Miculescu F,Negut I,Hapenciuc C

更新日期：2017-06-01 00:00:00