Abstract：
:The increasing prevalence of diabetes especially type 2 diabetes worldwide is indisputable. Diabetics suffer increased morbidity and mortality, compared to their non-diabetic counterparts, not only because of vascular complications, but also because of an increased fracture incidence. Both types 1 and 2 diabetes and some medications used to treat it are associated with osteoporotic fractures. The responsible mechanisms remain incompletely elucidated. In this review, we evaluate the role of glycemic control in bone health, and the effect of anti-diabetic medications such as thiazolidinediones, sulfonylureas, DPP-4 inhibitors, and GLP-1 agonists. In addition, we examine the possible role of insulin and metformin as anabolic agents for bone. Lastly, we identify the current and future screening tools that help evaluate bone health in diabetics and their limitations. In this way we can offer individualized treatment, to the at-risk diabetic population.
journal_name
Maturitasjournal_title
Maturitasauthors
Antonopoulou M,Bahtiyar G,Banerji MA,Sacerdote ASdoi
10.1016/j.maturitas.2013.04.004subject
Has Abstractpub_date
2013-11-01 00:00:00pages
253-9issue
3eissn
0378-5122issn
1873-4111pii
S0378-5122(13)00109-6journal_volume
76pub_type
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