Abstract:
OBJECTIVES:The purpose of this study was to investigate whether a previous fracture is a risk factor for fracture later in life and its association with tobacco smoking, menopausal age and the use of oral contraceptives. This is an epidemiological population study based on a questionnaire. A sample of 10000 women from seven birth cohorts between 1900-1940 was obtained at random from the population register. The overall response rate was 74.6%. The responders (n = 7459) represented 53% of the total population. METHODS:The women from all these birth cohorts were questioned regarding a possible history of fractures and the year in which they were sustained. The questionnaire also included questions about menopausal age, use of oral contraceptives, previous gynaecological operations and possible oestrogen medication. The women from the 1900-1920 birth cohorts were questioned in detail about urogenital disorders, while tobacco smoking data were recorded only for the 1930 and 1940 birth cohorts. RESULTS:The relative risk of sustaining a further fracture was significantly related to fracture premenopausally before 40 years of age and later fracture postmenopausally after 60 years of age (1.29; 0.97-1.70) compared to controls (0.78; 0.59-1.03)(P = 0.03). Both an early menopause and tobacco smoking were associated significantly with repeated fractures, while use of oral contraceptives had a protective effect against repeated fractures in the 1940 birth cohort. Logistic multiple regression showed that a fracture was a significant independent risk factor for further fracture in both cohorts 1900-1920 (P < 0.01) and 1930-1940 (P < 0.05). CONCLUSIONS:This study suggests poorer protective resources against new fractures among women with previous fractures, and that lack of oestrogen menopausally can partly explain the enhanced risk of fracture, not only during the menopause but also later in life when a hip fracture may have immense consequences. The results should draw our attention to emphasise the need for active treatment of patients with established osteoporosis because of the increased risk of new fractures later in life.
journal_name
Maturitasjournal_title
Maturitasauthors
Johansson C,Mellström Ddoi
10.1016/0378-5122(95)01024-6subject
Has Abstractpub_date
1996-05-01 00:00:00pages
97-106issue
1-2eissn
0378-5122issn
1873-4111pii
0378-5122(95)01024-6journal_volume
24pub_type
杂志文章相关文献
MATURITAS文献大全abstract:OBJECTIVE:In obese postmenopausal women with normal glucose metabolism (NGT) and impaired glucose tolerance (IGT) we assessed serum leptin, adiponectin, resistin, soluble leptin receptor (sOB-R) during oral glucose tolerance test (OGTT) in order to investigate their response to acute changes in glucose and insulin in t...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2008.03.012
更新日期:2008-04-20 00:00:00
abstract:OBJECTIVE:Ovarian cancer screening (OCS) for BRCA1/2 mutation carriers was stopped in our family cancer clinic in 2009 because of its ineffectiveness. The study objective was to investigate the effect of stopping OCS on the timing and uptake of risk-reducing salpingo-oophorectomy (RRSO) and on the percentage of occult ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2014.12.009
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:To determine the effects of a multicomponent physical exercise program on cognitive and affective functioning among nursing home residents and to clarify whether there are any changes in serum levels of brain-derived neurotrophic factor (BDNF) among participants. STUDY DESIGN:This was a single-blind randomi...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2019.10.014
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The present study was undertaken to assess the impact, effectiveness and safety of a monophasic hormone replacement treatment (HRT) for continuous use with regards to the clinical effects, bleeding patterns and lipid profile of menopausal women in four Latin American countries. DESIGN:Three hundred and six p...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.maturitas.2004.05.014
更新日期:2005-03-14 00:00:00
abstract::Premature ejaculation (PE) is the most common male sexual complaint, and may exert a profound negative impact on the man's life and partnership. Using currently available treatment alternatives (e.g., selective serotonin uptake inhibitor, agents acting locally on the penis), PE can be treated in most, but not all pati...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.06.007
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:The extent to which menopause influences wellbeing is unclear. We investigated the association between moderate-severely bothersome vasomotor symptoms (VMS) and psychological general wellbeing in women, aged 40-65 years, taking into account socio-demographic and lifestyle factors. STUDY DESIGN/MAIN OUTCOME ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.06.004
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement. METHODS:A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omni...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00124-9
更新日期:2000-06-30 00:00:00
abstract::The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5122(81)90003-7
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:Physical multimorbidity, defined as the presence of two or more chronic physical conditions, is widespread and reduces life expectancy and quality of life in older adults. Sedentary behavior (SB) is increasingly identified as a risk factor for a range of chronic physical conditions, independent of physical a...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.01.007
更新日期:2020-04-01 00:00:00
abstract::The present study had two objectives: (1) to register the prevalence of a number of climacteric complaints in a Danish general population cohort and (2) retrospectively to test the validity of an association between climacteric complaints, menopausal development, occurrence of life events and social background. A post...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(93)90043-h
更新日期:1993-11-01 00:00:00
abstract::There are few prospective data on temporal trends in overall sitting time for different domains of sitting. This study examined time trends over 6 years in total and domain-specific sitting time in mid-age Australian men and women. Self-report data from 5246 participants in four survey waves (2007, 2009, 2011, 2013) o...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.08.006
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it was hypothesized that the changes in blood pressure effected by ERT might ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0378-5122(03)00279-2
更新日期:2004-03-15 00:00:00
abstract:OBJECTIVES:To review the available information on the action of hormones on the mechanisms involved in thrombotic risk. RESULTS AND CONCLUSIONS:Thrombosis plays a crucial role in the genesis and progression of both coronary heart disease (CHD) and venous thromboembolic disease (VTED), the two main forms of cardiovascu...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/s0378-5122(01)00270-5
更新日期:2001-10-31 00:00:00
abstract::The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2017.04.014
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of hormone replacement therapy (HT) use by postmenopausal women doctors and doctors' wives in Italy and to explore the relationship between their personal characteristics and HT use. DESIGN:A total of 500 women doctors and 500 men doctors answering on behalf of their female partner...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.10.008
更新日期:2006-05-20 00:00:00
abstract:OBJECTIVE:We investigated, using color Doppler ultrasound, possible detectable blood changes of prolonged treatment with 17-beta-estradiol tablets on uterine artery blood flow, in a cohort of low risk postmenopausal women. METHODS:39 postmenopausal women, who were taking local estrogen therapy for at least 6 months, w...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2004.07.004
更新日期:2005-04-11 00:00:00
abstract::Ageing of human skin may result from both the passage of time (intrinsic ageing) and from cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation (UVR) which promote wrinkle formation and loss of tissue elasticity. Whilst both ageing processes are associated with phenotypic changes ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.04.011
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:mitral annular calcification (MAC) occurs mainly in middle-aged and elderly patients and can lead to serious clinical consequences. Male predominance in the prevalence of coronary disease is well-established. Paradoxically, the prevalence of MAC, which is theoretically based on the same etiological mechanism...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00120-1
更新日期:2000-07-31 00:00:00
abstract:OBJECTIVES:We conducted this study to examine premenopausal risk factors associated with premature ovarian failure (POF) and early menopause (EM) among Korean women. METHODS:A 73% of total women aged 30-69 at four districts in the KMCC (Korean Multi-center Cancer Cohort) was participated in this study during 2002-2003...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2007.04.001
更新日期:2007-09-20 00:00:00
abstract:OBJECTIVES:To characterise changes in nationwide fall-related mortality rates in Australia and the United Kingdom (UK) between 2006 and 2016 by age group and sex. STUDY DESIGN:Trend analysis of falls mortality data from World Health Organization (WHO) Mortality Database for the Australian and UK population. MAIN OUTC...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.07.008
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:To review some aspects in the recent literature related to the effects of postmenopausal estrogen and progestin use on major plasma lipoprotein risk factors for coronary heart disease (CHD). METHODS:Collection of relevant information from medical journals, and by the use of Medline and Current Contents. RE...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/0378-5122(96)01012-2
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Estetrol (E4) is a natural estrogen produced solely during human pregnancy. E4 is suitable for clinical use since it acts as a selective estrogen receptor modulator. In clinical trials E4 has been seen to have little or no effect on coagulation. Hence, it is interesting to investigate whether E4 alters endot...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.02.005
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:It has become popular to assert that Asian women in general have low midlife rates of reporting a wide variety of symptoms and that these rates are much lower than those found among women in western countries. Comparable data from mainland China remains sparse, however. This study aimed to uncover the sympto...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.12.010
更新日期:2006-08-20 00:00:00
abstract::Elderly subjects with cognitive disorders are at particularly high risk of adverse drug reactions (ADRs). The objectives of our systematic review were to describe the prevalence of ADRs in elderly patients with cognitive disorders, the different types of ADRs and the medications suspected of involvement; to describe w...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.12.013
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:To establish dose proportionality among four doses of a new estradiol transdermal system (ETS), Estradot, in healthy postmenopausal women and to evaluate the wear and irritation properties of the ETS. METHODS:In an open label, single-dose, randomized, four-period crossover study, healthy postmenopausal wome...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(03)00189-0
更新日期:2003-11-20 00:00:00
abstract:OBJECTIVE:The present study investigated bone turnover with exchange of hormone replacement therapy (HRT) by treatment with 1alpha-hydroxycholecalciferol in early postmenopausal women. METHODS:Subjects included a total of 75 postmenopausal women between 49 and 59 years of age who visited the Department of Obstetrics a...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(03)00130-0
更新日期:2003-06-30 00:00:00
abstract:INTRODUCTION:Loss of muscle strength is associated with falls, which, in turn, are the main cause of hip fractures in elderly people. The factors that most influence loss of strength in elderly people are a decrease in muscle mass, i.e. sarcopenia, and an increase in fat, i.e. obesity. METHODS:A prospective randomized...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2013.06.016
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:We analysed the risk factors for clinically diagnosed uterine fibroids in women attending menopause clinics in Italy. METHODS:Between 1997 and 2003 we conducted a large cross-sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in It...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.01.013
更新日期:2006-09-20 00:00:00
abstract:BACKGROUND:With the significant improvement of the cure rate and survival rate of cancer patients, the survivors face quality-of-life problems, such as a significant decline in reproductive system development, ovarian reserves and function, and even fertility loss and early menopause. These problems are often highly as...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.04.010
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:There is an assumption in menopause research that attitudes to menopause are influenced by a range of cultural, social and psychological variables, which may in turn affect menopausal experience and symptom reporting. However, many studies draw conclusions about this relationship without explicitly examining...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2009.10.016
更新日期:2010-01-01 00:00:00