Abstract：
:Premature ejaculation (PE) is the most common male sexual complaint, and may exert a profound negative impact on the man's life and partnership. Using currently available treatment alternatives (e.g., selective serotonin uptake inhibitor, agents acting locally on the penis), PE can be treated in most, but not all patients. However, since long term success rates have been disappointing, and the only approved treatment so far is the short-acting selective serotonin re-uptake inhibitor dapoxetine, there is currently an intensive search for new treatment modalities. Selection of the most promising therapeutic targets from a host of current and potential candidates depends heavily on their roles in the pathophysiology of PE. Possible central nervous targets that will be discussed are serotonin transporters, and CNS receptors for 5-HT(IA) and 5-HT(1B), dopamine, oxytocin, opioids, neurokinin-1, and glutamate. Putative peripheral targets include α(1)-adrenoceptors, phosphodiestrase enzymes, Rho kinases, purinergic (P2X) receptors, and penile sensory nerves. It is clear that exploiting the full therapeutic potential of these targets will require additional basic and clinical research.
journal_name
Maturitasjournal_title
Maturitasauthors
Andersson KE,Abdel-Hamid IAdoi
10.1016/j.maturitas.2011.06.007subject
Has Abstractpub_date
2011-09-01 00:00:00pages
26-33issue
1eissn
0378-5122issn
1873-4111pii
S0378-5122(11)00206-4journal_volume
70pub_type
杂志文章,评审相关文献
MATURITAS文献大全abstract：BACKGROUND:With the significant improvement of the cure rate and survival rate of cancer patients, the survivors face quality-of-life problems, such as a significant decline in reproductive system development, ovarian reserves and function, and even fertility loss and early menopause. These problems are often highly as...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2020.04.010
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:There is evidence that menopausal symptoms manifested at peri-menopause occur less frequently when compared to the symptoms experienced at post-menopause. The aim of this study was to investigate this and to test the hypothesis that depressive symptomatology mediates the relationship between menopausal stage...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.03.007
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Participation in regular physical activity is among the most promising and cost effective strategies to reduce physical and cognitive decline and premature death. However, confusion remains about the amount, frequency, and duration of physical activity that is likely to provide maximum benefit as well as the...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2014.06.010
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:We investigated the association of visceral fat with the metabolic syndrome (MetS) and its separate components; the associations of both physical activity and muscle strength with the MetS and its separate components independent of visceral fat. Furthermore, we studied these associations within participants w...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2013.06.015
更新日期：2013-10-01 00:00:00
abstract：:Peyronie's disease is an incurable, sexually debilitating fibrotic disease of the penis that results in penile curvature, coital failure, and significant psychological stress for patients and their partners. Appropriate treatment should be individualized and tailored to the patient's goals and expectations, disease hi...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2014.05.024
更新日期：2014-08-01 00:00:00
abstract：:The change in lumbar vertebral bone mineral density (BMD) during a 2-year study period was examined in 167 healthy middle-aged and elderly Japanese women with reference to age, menopausal status and bone turnover markers at baseline. The perimenopausal and postmenopausal groups of the subjects showed a significant los...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(96)01042-0
更新日期：1996-08-01 00:00:00
abstract：:Dementia is a major source of disability worldwide and there are currently no available disease-modifying treatments. Hearing loss may be associated with increased risk of dementia in later life and therefore could be a modifiable risk factor, given the availability of efficacious interventions. We investigated the as...
journal_title：Maturitas
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.maturitas.2018.03.004
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:Given the asymptomatic nature of osteoporosis, a fragility fracture provides an opportunity to make the issue of osteoporosis relevant to patients. Patients who link their fragility fracture with osteoporosis are more likely to initiate osteoporosis treatment, yet to date, we know little about who is likely t...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2013.07.014
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate the prevalence of depressive symptoms in peri- and post-menopausal Taiwanese women, and to investigate the relation between depressive symptoms and demographic variables, chronic disease status, health habits, stress management, menopausal symptoms, and attitudes towa...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2013.04.021
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:The physiological role of parathormone (PTH) in the maintenance of bone mass in humans has not been fully defined. The main objective of the present study was to evaluate basal and EDTA-stimulated PTH levels in young women (Group Y=30.9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2007.10.002
更新日期：2008-01-20 00:00:00
abstract：:Menopause marks a time of dramatic hormonal and often social change for women. Both risk factors and health needs are likely to change as women pass through menopause. This paper examines the demographic characteristics of the world population of menopausal and post-menopausal women, and also examines the implication ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/0378-5122(95)00968-x
更新日期：1996-03-01 00:00:00
abstract：OBJECTIVES:An internet survey was performed to obtain data on the current use in Belgium of hormone replacement therapy and alternative treatments for the alleviation of menopausal symptoms. A supplementary aim was to assess the use of opt-in internet opinion panels (TalkToChange, http://www.talktochange.com, and GMI, ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.04.018
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:To study long-term compliance with oral hormonal replacement therapy (HRT). METHODS:A total of 151 early postmenopausal women were initially randomly allocated to three groups in a double-blind, placebo controlled trial. Fifty women received continuous combined therapy, another 50 were placed on sequential t...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00921-7
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVES:This paper aims to report the methodology of a study of a cohort of middle-aged women in Taiwan, their age at menopause, and related factors and prevalence of menopausal symptoms, and to examine the relationships between symptoms and sociodemographic variables. METHODS:An epidemiological study of neuropsych...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(01)00193-1
更新日期：2001-08-25 00:00:00
abstract：:Combination therapy strategies for osteoporosis are reviewed in this article. Regimens including two antiresorptives agents increase BMD more than single therapy alone, but they have not proved to reduce fracture risk. The alternative of combining antiresorptives together with anabolics has gained more interest. There...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2005.08.011
更新日期：2006-04-20 00:00:00
abstract：:There are few prospective data on temporal trends in overall sitting time for different domains of sitting. This study examined time trends over 6 years in total and domain-specific sitting time in mid-age Australian men and women. Self-report data from 5246 participants in four survey waves (2007, 2009, 2011, 2013) o...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.08.006
更新日期：2018-10-01 00:00:00
abstract：:In a population-based prospective study it was shown that weight, height, overweight, total body size, age at first birth, parity and age at menopause are risk factors for the development of endometrial cancer. The finding that the patients had had a higher oestrogen excretion level than the controls some time before ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(85)90036-2
更新日期：1985-05-01 00:00:00
abstract：:Population health outcomes are shaped by complex interactions between individuals and the environments in which they live, work and play. Environments encompass streets and buildings (physical environment), attitudes, supports and relationships with others (social environment), as well as social and political systems ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2009.07.011
更新日期：2009-09-20 00:00:00
abstract：OBJECTIVES:To study whether dose adjustments in transdermal estradiol gel treatment would result in proportional changes in estradiol bioavailability and concentrations. METHODS:In an open study, 23 healthy postmenopausal women were treated consecutively with 0.5, 1.0 and 1.5 mg estradiol daily as a transdermal gel. E...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00101-8
更新日期：2000-04-28 00:00:00
abstract：OBJECTIVE:To investigate the relationship between hormone replacement therapy (HRT) and level of cognitive performance intra-individual variability, and interactions with statin use, progesterone therapy and type of menopause. METHODS:A representative sample of 60-64 year olds was recruited from the Canberra and Quean...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2005.09.001
更新日期：2006-04-20 00:00:00
abstract：OBJECTIVES:We studied the effect of hormonal treatment on skin ageing in menopausal women. METHODS:Twenty-four patients (45-68 years; mean age, 54.9 years) without hormone treatment for at least 6 months were included. Patients were assigned to three therapy groups: 1, oestrogen only (Estraderm TTS 50) (n=6); 2, trans...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(00)00225-5
更新日期：2001-07-25 00:00:00
abstract：OBJECTIVES:To compare the metabolic and endocrinological effects of estradiol valerate/cyproterone acetate (EV/CPA) to a regimen of conjugated estrogens/medroxyprogesterone acetate (CE/MPA) in postmenopausal women. METHODS:Lipid profile, endocrinological parameters, coagulation factors, renin and angiotensinogen were ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(97)00042-x
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2013.07.001
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to investigate whether a previous fracture is a risk factor for fracture later in life and its association with tobacco smoking, menopausal age and the use of oral contraceptives. This is an epidemiological population study based on a questionnaire. A sample of 10000 women from ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(95)01024-6
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:To compare the influence on lipid metabolism of two discontinuous, sequentially combined hormone replacement therapy (HRT) regimens. STUDY DESIGN:In an open, randomized study in 60 women, a full lipid profile including Lp(a) and liver function tests were assessed in a fasting state at the end of treatment cy...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00920-g
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:Studies assessing physical functionality with questions on ability to perform activities of daily living (ADLs) commonly make use of self- and informant-report measures. OBJECTIVES:Delineate the scenarios from which disagreement can arise and show evidence for the presence of disagreements when reporting on...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.06.012
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To determine the effects of oral sequential hormone replacement therapy (HRT) on lipid-profile in perimenopausal and early postmenopausal women. METHODS:We performed a single-center, randomized, placebo-controlled trial. The trial was double blind with respect to 17beta-estradiol/desogestrel (17beta-E-D) and...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(01)00224-9
更新日期：2001-09-28 00:00:00
abstract：OBJECTIVES:Vitamin D is involved in skeletal and brain health. Recently, serum 25-hydroxyvitamin D (25OHD) concentration was found to be inversely correlated with intracranial volume in younger adults. Since hypovitaminosis D is most common in older adults, our objective was to determine whether this inverse correlatio...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2014.12.011
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:The present study investigated bone turnover with exchange of hormone replacement therapy (HRT) by treatment with 1alpha-hydroxycholecalciferol in early postmenopausal women. METHODS:Subjects included a total of 75 postmenopausal women between 49 and 59 years of age who visited the Department of Obstetrics a...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(03)00130-0
更新日期：2003-06-30 00:00:00
abstract：:A group of 72 postmenopausal women were treated for 4 weeks with vaginal suppositories containing 0.5 or 1.0 mg of estriol. The two different doses achieved an identical significant improvement of urogenital symptoms, while a dose-related effect seen to be on climacteric complaints, according to a good absorption of e...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00943-f
更新日期：1995-11-01 00:00:00
