Abstract：
:The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the host's immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the host's immune system, leading to metastasis and/or recurrent disease.
journal_name
Maturitasjournal_title
Maturitasauthors
Kuol N,Stojanovska L,Nurgali K,Apostolopoulos Vdoi
10.1016/j.maturitas.2017.04.014subject
Has Abstractpub_date
2017-11-01 00:00:00pages
8-15eissn
0378-5122issn
1873-4111pii
S0378-5122(17)30531-5journal_volume
105pub_type
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