Abstract:
OBJECTIVE:The present study investigated bone turnover with exchange of hormone replacement therapy (HRT) by treatment with 1alpha-hydroxycholecalciferol in early postmenopausal women. METHODS:Subjects included a total of 75 postmenopausal women between 49 and 59 years of age who visited the Department of Obstetrics and Gynecology at Osaka Medical College Hospital for regular gynecological checkups and menopausal disorder, postmenopausal osteoporosis or hyperlipidemia, and were diagnosed with menopausal disorder or osteopenia. Changes in bone turnover and vertebral bone mineral density (BMD) in 28 patients who had undergone HRT; conjugated equine estrogen 0.625 mg daily and medroxyprogesterone acetate 2.5 mg daily) for at least 2 years and then switched to 1alpha-hydroxycholecalciferol (0.5 microg orally twice daily) and in 26 patients who were observed without drug administration after discontinuation of HRT were compared with those in 37 patients who continued HRT. BMD of the lumbar spine (L2-4) was determined using Dual Energy X-ray Absorptiometry. RESULTS:While we observed a significant decrease in vertebral bone mass in the HRT-no medication group at 12 months (P=0.049) and 18 months (P=0.013), there was no significant decrease in vertebral bone mass in either the continuous HRT group or the group with change of HRT to 1alpha-hydroxycholecalciferol. In the group with change of HRT to 1alpha-hydroxycholecalciferol, although urinary pyridinoline level increased significantly from the baseline level throughout the study period (P<0.05), serum propeptide of type-1 procollagen (P1CP) level also increased significantly from the baseline level throughout this period (P<0.001). Furthermore, significant increase from the baseline value (P<0.01) was observed in serum osteocalcin level at 6, 12 and 18 months. CONCLUSIONS:These results indicate that switching to 1alpha-hydroxycholecalciferol therapy after short-term HRT increased both bone resorption and bone formation, and permitted maintenance of increase in bone mass due to HRT for at least 18 months, though this switching accelerated bone turnover. This may have occurred because stimulation of bone formation induced by HRT was maintained by 1alpha-hydroxycholecalciferol, though bone turnover was slightly promoted because of withdrawal of HRT. This method was thus found to be very effective in preventing bone loss in patients who have discontinued HRT and are considered relatively contraindicated for use of estrogen.
journal_name
Maturitasjournal_title
Maturitasauthors
Ushiroyama T,Ikeda A,Sakai M,Higashiyama T,Ueki Mdoi
10.1016/s0378-5122(03)00130-0keywords:
subject
Has Abstractpub_date
2003-06-30 00:00:00pages
119-27issue
2eissn
0378-5122issn
1873-4111pii
S0378512203001300journal_volume
45pub_type
杂志文章相关文献
MATURITAS文献大全abstract:OBJECTIVE:To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience. METHODS: SUBJECTS:Women 2-7 years post-menopause with a uterus and not currently on hormone replacement therapy. Questionnaire development: A list of 106 meno...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(96)82006-8
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:A traditional asiatic phytoestrogen-rich diet is associated with a lower incidence of estrogen-dependent cancers and clinical consequences of postmenopausal estrogen deficiency. First Wilcox in 1990, showed an increase of the vaginal cell maturation with phytoestrogens on postmenopausal women, but this has n...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(03)00080-x
更新日期:2003-08-20 00:00:00
abstract:OBJECTIVES:Pilot study to compare the effects of a continuous combined hormone replacement therapy (HRT) regimen with an interrupted progestogen regimen administered transdermally, upon the endometrium of postmenopausal women, the incidence of amenorrhoea and relief of menopausal symptoms. METHODS:Fifty-nine postmenop...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2005.01.013
更新日期:2006-01-10 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the timing of withdrawal bleeding on hormone replacement therapy and the state of the endometrium. DESIGN:Double-blind, prospectively randomised dose-ranging study. SETTING:Menopause clinics in the UK and the Netherlands. SUBJECTS:Two hundred and seventy one postmeno...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(99)00101-2
更新日期:2000-02-15 00:00:00
abstract::Health care focuses on controlling symptoms and managing risk factors to improve survival by avoiding future complications. Diagnoses describe a group of signs and symptoms, often implying specific aetiologies and underlying pathophysiological disease processes. The diagnosis provides a tool for the health professiona...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2019.02.010
更新日期:2019-05-01 00:00:00
abstract::Hot flashes are a common complaint among women as they transition through menopause. This article reviews the evidence of lifestyle alterations for the amelioration of hot flashes including obesity, exercise, smoking, relaxation techniques, and acupuncture. Further randomized controlled trials regarding these lifestyl...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2011.12.006
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To determine whether individually tailored acupuncture is an effective treatment option for reducing postmenopausal hot flashes and improving quality of life. METHODS:In a randomized, placebo-controlled pilot study, 29 postmenopausal participants averaging at least seven moderate to severe hot flashes per 24...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2006.11.001
更新日期:2007-04-20 00:00:00
abstract:OBJECTIVES:Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this internation...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.maturitas.2003.12.012
更新日期:2004-07-15 00:00:00
abstract:OBJECTIVES:Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(03)00247-0
更新日期:2004-02-20 00:00:00
abstract:OBJECTIVE:Many observational studies suggest hormone therapy protects against coronary heart disease in contrast to findings from large randomised clinical trials and an observational Danish study. A potential bias in the observational literature concerning the cardiovascular risk and benefits associated with use of ho...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2004.05.011
更新日期:2005-07-16 00:00:00
abstract::Peyronie's disease is an incurable, sexually debilitating fibrotic disease of the penis that results in penile curvature, coital failure, and significant psychological stress for patients and their partners. Appropriate treatment should be individualized and tailored to the patient's goals and expectations, disease hi...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2014.05.024
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:To examine the potential of a new matrix system developed for estradiol delivery to cause microbial proliferation under the occluded site or to cause acute phototoxicity reactions. METHODS:Twenty healthy post-menopausal women participated in a microbial proliferation study and 11 in a phototoxicity study. B...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(96)01062-6
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Previously, the REDLINC VI study showed that the main reason for the low use of menopausal hormone therapy (MHT) was its low rate of prescription by doctors. OBJECTIVE:To determine the use of MHT and perceived related risks among gynecologists. METHODS:A self-administered and anonymous questionnaire was de...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.maturitas.2016.02.015
更新日期:2016-05-01 00:00:00
abstract::The aim of this chronobiological study was to investigate temporal correlations in the circadian patterns of 6 hormones, namely somatotrophic hormone (STH), prolactin (PRL), cortisol (F), aldosterone (ALD), insulin (IRI) and C-peptide (CP), assayed in systemic blood serum drawn at 07:00, 10:00, 13:00, 16:00, 19:00 and...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(85)90024-6
更新日期:1985-07-01 00:00:00
abstract:OBJECTIVES:It has become popular to assert that Asian women in general have low midlife rates of reporting a wide variety of symptoms and that these rates are much lower than those found among women in western countries. Comparable data from mainland China remains sparse, however. This study aimed to uncover the sympto...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.12.010
更新日期:2006-08-20 00:00:00
abstract:OBJECTIVE:Impaired vision and hearing are common among older adults and have been shown to reduce functional independence and to reduce quality of life. This cohort study investigated the cross-sectional and temporal associations between objectively measured dual sensory impairment (DSI) and retirement from employment....
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.03.318
更新日期:2017-06-01 00:00:00
abstract::Forty-five healthy postmenopausal women participated in a study designed to examine the effects on bone and mineral metabolism of SHD 386L, a new hormone replacement therapy (HRT) regime. This oral preparation delivers 2 mg estradiol valerate daily and 75 micrograms of levonorgestrel from days 17-28 inclusive of a 28-...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(92)90114-j
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). METHODS:187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(01)00259-6
更新日期:2002-02-26 00:00:00
abstract:BACKGROUND:With the significant improvement of the cure rate and survival rate of cancer patients, the survivors face quality-of-life problems, such as a significant decline in reproductive system development, ovarian reserves and function, and even fertility loss and early menopause. These problems are often highly as...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.04.010
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To evaluate individual characteristics of women with fibroids in relation to fibroid size and number. METHODS:This cross-sectional study involved 2302 women (black and white, age range 18-87) with image- or surgery-confirmed fibroids from the Synthetic Derivative, a database of de-identified demographic and ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2018.05.003
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:To describe the prevalence of hormone replacement therapy (HT) use by postmenopausal women doctors and doctors' wives in Italy and to explore the relationship between their personal characteristics and HT use. DESIGN:A total of 500 women doctors and 500 men doctors answering on behalf of their female partner...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2005.10.008
更新日期:2006-05-20 00:00:00
abstract::Epidemiological studies have shown that cigarette smoking is associated with an increased risk of midlife hot flashes; however, the effect of quitting smoking on this risk is unclear. The purpose of this study was to examine the effect of quitting smoking on hot flashes using data from 761 women aged 45 to 54 years of...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.06.029
更新日期:2015-09-01 00:00:00
abstract::It is widely recognised that women's sexuality can be particularly complex after breast cancer, with sexual changes often becoming the most problematic aspect of a woman's life. The impact of such changes can last for many years after successful treatment, and can be associated with serious physical and emotional side...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2010.03.027
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Traditionally, general practitioners (GPs) are not involved in cancer-related treatment decisions, despite their often long relationship with patients, and their unique position to explore patients' values, especially with older patients. Therefore, we designed a randomised controlled trial to study the effect,...
journal_title:Maturitas
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.maturitas.2016.11.014
更新日期:2017-02-01 00:00:00
abstract::The aim of this review was to systematically assess the effectiveness of aromatherapy for stress management. Seven databases were searched from their inception through April 2014. RCTs testing aromatherapy against any type of controls in healthy human person that assessed stress level and cortisol level were considere...
journal_title:Maturitas
pub_type: 杂志文章,meta分析
doi:10.1016/j.maturitas.2014.08.006
更新日期:2014-12-01 00:00:00
abstract::Recent findings in stem cell biology have presented new perspectives and opportunities for the treatment of reproductive disease. In a departure from the long held dogma of embryologically fixed numbers of oocytes, current literature suggests that human ovaries contain stem cells which form new oocytes even in adultho...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2013.08.012
更新日期:2013-11-01 00:00:00
abstract::The mean plasma anion gap (Na + K + Ca + Mg)--(Cl + HCO3(-) + HPO4(2-) + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/l). This change was due, in part, to an increase in the plasma lactate concentration and to smaller increases in cit...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(84)90049-5
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVES:The menopause rating scale (MRS) has been developed as a modern tool for the assessment of menopausal complaints. It combines in practice excellent applicability and a good reliability, and there are normal values for the population available. For further practical evaluation, the MRS was applied in order to...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(00)00177-8
更新日期:2000-12-29 00:00:00
abstract::S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptab...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/s0378-5122(00)00175-4
更新日期:2001-01-31 00:00:00
abstract:OBJECTIVES:C-telopeptide crosslaps (CTX) and bone-specific alkaline phosphatase (BAP) do not provide sufficient sensitivity and specificity for diagnosis of osteoporosis. Cathepsin K (CatK), osteoprotegerin (OPG), and receptor activator of nuclear factor κB ligand (total (t) and soluble (s) RANKL) play an important rol...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.01.005
更新日期:2013-04-01 00:00:00