Abstract：
:Serum cholesterol concentrations in lipoprotein fractions and subfractions were determined in 11 peri-menopausal women both before and after bilateral oophorectomy, as well as 60 days after commencement of oral oestradiol replacement therapy. Pre-operatively, all subjects were found to have normal lipid and lipoprotein concentrations. There was a post-operative increase in the total cholesterol level, which was attributed to a raised very-low-density lipoprotein (VLDL) cholesterol. Changes in high-density lipoprotein (HDL) subfractions HDL-2 and HDL-3 were noted but since these were compensatory little difference in total HDL cholesterol was observed. Following oral oestrogen replacement, the cholesterol level decreased as a result of a drop in both VLDL and low-density lipoprotein (LDL) cholesterol. The oestradiol-induced HDL cholesterol increment reflected an increase in the levels of both HDL subfractions.
journal_name
Maturitasjournal_title
Maturitasauthors
Blumenfeld Z,Aviram M,Brook GJ,Brandes JMdoi
10.1016/0378-5122(83)90002-6subject
Has Abstractpub_date
1983-08-01 00:00:00pages
77-83issue
2eissn
0378-5122issn
1873-4111pii
0378-5122(83)90002-6journal_volume
5pub_type
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