Abstract:
INTRODUCTION:Strategies in case of high risk of breast cancer in BRCA1/2 mutation carriers are either intensive breast cancer screening or risk-reducing mastectomy (RRM). Both options have a high physical and psychosexual impact. The aim of this study is to investigate who chooses when to undergo RRM. METHODS:BRCA1/2 mutation carriers have been prospectively registered at the family cancer clinic between 1994 and 2011. Analyses were performed to assess the relation between characteristics of the BRCA1/2 mutation carriers and an earlier decision for RRM. RESULTS:A cumulative percentage of 35.6% of all women chose to undergo RRM within the first five years after disclosure of DNA test results. Women needed less time to choose for RRM measured from the first visit, if they were younger than 50 years of age (hazard ratio (HR)=2.67, 95% confidence interval (CI)=1.30-5.48) or had a mother who had had breast cancer (HR=1.51 95% CI=1.04-2.18). Also, women needed less time to choose for RRM in case of a previous breast cancer (HR=2.25, 95% CI=1.55-3.27). After a previous unilateral therapeutic mastectomy as a treatment for breast cancer, women needed less time to choose for RRM of the contralateral breast (HR=2.69, 95% CI=1.29-5.62) compared to women who had had breast-conserving therapy. CONCLUSION:BRCA1/2 mutation carriers aged under 50, having a mother with breast cancer, who had previous unilateral breast cancer and previous unilateral therapeutic mastectomy chose more often and earlier for RRM.
journal_name
Maturitasjournal_title
Maturitasauthors
van Driel CM,Eltahir Y,de Vries J,Jaspers JP,Oosterwijk JC,Mourits MJ,de Bock GHdoi
10.1016/j.maturitas.2013.10.017subject
Has Abstractpub_date
2014-02-01 00:00:00pages
180-4issue
2eissn
0378-5122issn
1873-4111pii
S0378-5122(13)00328-9journal_volume
77pub_type
杂志文章相关文献
MATURITAS文献大全abstract::Unpaid, informal carers play a vital role in supporting people with long-term conditions. Being a carer can be challenging and carers may need support but they frequently fail to access it. Compared to research investigating the experiences of female carers, research with male carers is underdeveloped. The available e...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2015.07.013
更新日期:2015-10-01 00:00:00
abstract::This study investigated the effect of ageing and reduction in ovarian function on whole blood serotonin levels and the effect of the oestrogen replacement in postmenopausal women on blood serotonin levels. Amenorrheic, natural postmenopausal and ovariectomised women had lower blood serotonin levels than regularly mens...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(93)90120-7
更新日期:1993-07-01 00:00:00
abstract::We designed a randomized double-blind randomized trial to examine the short and long-term effects of alternative approaches commonly used to manage menopause symptoms. Women were randomly assigned to: (1) black cohosh 160 mg daily; (2) multibotanical (50 mg black cohosh, alfalfa, chaste tree, dong quai, false unicorn,...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2008.11.014
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the prevalence of depressive symptoms in peri- and post-menopausal Taiwanese women, and to investigate the relation between depressive symptoms and demographic variables, chronic disease status, health habits, stress management, menopausal symptoms, and attitudes towa...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.04.021
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To compare clinical characteristics and management of adnexal torsion in postmenopausal patients as compared to premenopausal ones. METHODS:A retrospective 22 year cohort of all cases of surgically verified adnexal torsion in postmenopausal and premenopausal patients, comparing presentation, imaging, surgica...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.02.261
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:To compare the metabolic and endocrinological effects of estradiol valerate/cyproterone acetate (EV/CPA) to a regimen of conjugated estrogens/medroxyprogesterone acetate (CE/MPA) in postmenopausal women. METHODS:Lipid profile, endocrinological parameters, coagulation factors, renin and angiotensinogen were ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(97)00042-x
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Estetrol (E4) is a natural estrogen produced solely during human pregnancy. E4 is suitable for clinical use since it acts as a selective estrogen receptor modulator. In clinical trials E4 has been seen to have little or no effect on coagulation. Hence, it is interesting to investigate whether E4 alters endot...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.02.005
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Menopausal status is a common covariate in epidemiologic studies. Still, there are no standard definitions for menopausal status using observational data. This study assesses distinctions between menopausal status definitions using commonly collected epidemiologic data, and explores their impact on study out...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2010.04.015
更新日期:2010-09-01 00:00:00
abstract::From an initial group of 39, 16 cycling peri-menopausal women completed a longitudinal study in which they recorded menstrual and sexual behavior daily and were interviewed at roughly 4-mth intervals until 1 yr or more without cycling. At each interview women gave 20-ml blood samples, completed sexuality questionnaire...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(85)90041-6
更新日期:1985-09-01 00:00:00
abstract::Dementia affects approximately 6.5% of people over the age of 65. Whilst cognitive impairment is central to the dementia concept, neuropsychiatric symptoms are invariably present at some stage of the illness. Neuropsychiatric symptoms result in a number of negative outcomes for the individual and their caregivers and ...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2014.04.005
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Previously, the REDLINC VI study showed that the main reason for the low use of menopausal hormone therapy (MHT) was its low rate of prescription by doctors. OBJECTIVE:To determine the use of MHT and perceived related risks among gynecologists. METHODS:A self-administered and anonymous questionnaire was de...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.maturitas.2016.02.015
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the timing of withdrawal bleeding on hormone replacement therapy and the state of the endometrium. DESIGN:Double-blind, prospectively randomised dose-ranging study. SETTING:Menopause clinics in the UK and the Netherlands. SUBJECTS:Two hundred and seventy one postmeno...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(99)00101-2
更新日期:2000-02-15 00:00:00
abstract::Peyronie's disease is an incurable, sexually debilitating fibrotic disease of the penis that results in penile curvature, coital failure, and significant psychological stress for patients and their partners. Appropriate treatment should be individualized and tailored to the patient's goals and expectations, disease hi...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2014.05.024
更新日期:2014-08-01 00:00:00
abstract::The possibility that the sudden discharge of thyrotropin-releasing hormone (TRH) in the brain triggers the climacteric hot flash was tested (double-blind) by an intra-venous, bolus injection of 500 microgram of TRH into 7 post-menopausal women and 1 menstruating control. Temperatures and sweating were recorded continu...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/0378-5122(81)90003-7
更新日期:1981-08-01 00:00:00
abstract::Epidemiological studies have shown that cigarette smoking is associated with an increased risk of midlife hot flashes; however, the effect of quitting smoking on this risk is unclear. The purpose of this study was to examine the effect of quitting smoking on hot flashes using data from 761 women aged 45 to 54 years of...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2015.06.029
更新日期:2015-09-01 00:00:00
abstract:RATIONALE:The association between early menarche and new onset of asthma warrants further investigation in those aged >30 years. OBJECTIVES:Using data from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), we investigated whether early menarche was associated with new onset of a...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.04.012
更新日期:2017-07-01 00:00:00
abstract::Two-thirds of patients with type 2 diabetes mellitus (T2DM) have arterial hypertension. Hypertension increases the incidence of both micro- and macrovascular complications in these patients, while the co-existence of these two major risk factors leads to a four-fold increased risk for cardiovascular disease (CVD) comp...
journal_title:Maturitas
pub_type: 杂志文章,评审
doi:10.1016/j.maturitas.2018.03.013
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:To investigate if women with a history of having experienced intimate partner violence (IPV) who undertook caregiving would experience worse mental and physical health compared to those without caregiving roles. STUDY DESIGN AND MAIN OUTCOME MEASURES:IPV, caregiving history and data on covariates were colle...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2017.05.001
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to observe hysterectomized postmenopausal women (without progestogen, which could interfere in the results), using oral-conjugated oestrogen 0.625 mg daily (n=13) or 17beta-estradiol transdermal patches delivering 50 microg daily (n=10) during 12 months, and to evaluate the treatmen...
journal_title:Maturitas
pub_type: 临床试验,杂志文章
doi:10.1016/s0378-5122(03)00159-2
更新日期:2003-09-25 00:00:00
abstract:OBJECTIVES:To examine the effect of Cimicifuga racemosa (CR BNO 1055) on hot flushes caused by tamoxifen adjuvant therapy in young premenopausal breast cancer survivors. This treatment presents an off-label use of CR BNO 1055. METHODS:Between May 1999 and December 2001, we accrued 136 breast cancer survivors aged 35-5...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0378-5122(02)00349-3
更新日期:2003-03-14 00:00:00
abstract:OBJECTIVE:We investigated, using color Doppler ultrasound, possible detectable blood changes of prolonged treatment with 17-beta-estradiol tablets on uterine artery blood flow, in a cohort of low risk postmenopausal women. METHODS:39 postmenopausal women, who were taking local estrogen therapy for at least 6 months, w...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2004.07.004
更新日期:2005-04-11 00:00:00
abstract:OBJECTIVE:Given the asymptomatic nature of osteoporosis, a fragility fracture provides an opportunity to make the issue of osteoporosis relevant to patients. Patients who link their fragility fracture with osteoporosis are more likely to initiate osteoporosis treatment, yet to date, we know little about who is likely t...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2013.07.014
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVES:To explore any feelings and symptoms surrounding menopause among Mayan women in three ethnolinguistic groups in highland Guatemala and compare these with previous reports from Mexico. METHODS:This was a qualitative exploratory study of the experiences around menopause of eight middle aged women and one loca...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(03)00036-7
更新日期:2003-04-25 00:00:00
abstract:OBJECTIVES:Cryostorage of ovarian cortical tissue, before devastating chemo- and/or radiotherapy for cancer, permits survival of primordial and early preantral follicles. This work aims for a system allowing the long-term maturation in vitro (IVM) of small immature oocytes up to fertilisable metaphase II oocytes. METH...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/s0378-5122(98)00071-1
更新日期:1998-10-12 00:00:00
abstract:OBJECTIVES:To investigate the influence and specificity of sociodemographic and psychological factors on the perception of symptoms associated with menopause. STUDY DESIGN:Data are based on a nationwide cross-sectional survey study in Germany. A representative sample of 1350 females aged 14-95 years was examined. Soci...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2020.03.004
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To describe the characteristics of women seeking treatment for symptoms of urinary incontinence (UI) in European countries. DESIGN:Prospective urinary incontinence research (PURE) was a 6-month, observational, pan-European study, primarily aimed at determining the direct costs of urinary incontinence treatme...
journal_title:Maturitas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.maturitas.2005.09.003
更新日期:2005-11-30 00:00:00
abstract::The secretory endometrial protein PP14 was measured in serum from 49 healthy, early post-menopausal women receiving continuous combined oestradiol valerate/cyproterone acetate (2 mg E2V + 1 mg CPA daily) or placebo over a period of 2 years. In the hormone group, serum PP14 increased from 2.1 micrograms/l to a maximum ...
journal_title:Maturitas
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0378-5122(92)90060-h
更新日期:1992-08-01 00:00:00
abstract::Examining such terms as climacteric or menopause and utilizing supportive historical data, an attempt is made to trace the development of these concepts, their time of inception and their spread. It is suggested that the persistence of popular terminology of the climacteric, especially in England, until late in the la...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(81)90013-x
更新日期:1981-03-01 00:00:00
abstract::The maturation value (MV), cervical mucus parameters (ferning, Spinnbarkeit), oestrone (E1), oestradiol (E2), oestriol (E3), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), thyrotropin (TSH), growth hormone (GH), sex hormone binding globulin (SHBG), corticosteroid binding globulin (CBG) ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/0378-5122(81)90041-4
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate gynecologists' knowledge of the WHI study, and its repercussions on their attitudes and practice 3 years after publication. DESIGN:A self-administered, anonymous questionnaire containing 19 questions was sent to 6000 gynecologists, members of the São Paulo Society ...
journal_title:Maturitas
pub_type: 杂志文章
doi:10.1016/j.maturitas.2006.06.022
更新日期:2007-02-20 00:00:00