Blood serotonin levels in postmenopausal women: effects of age and serum oestradiol levels.

Abstract:

:This study investigated the effect of ageing and reduction in ovarian function on whole blood serotonin levels and the effect of the oestrogen replacement in postmenopausal women on blood serotonin levels. Amenorrheic, natural postmenopausal and ovariectomised women had lower blood serotonin levels than regularly menstruating women. Blood serotonin levels increased after oestrogen replacement in postmenopausal women to values similar to those observed in regularly menstruating women. In ovariectomised women, the blood serotonin levels were inversely correlated with age (P < 0.01). In women with different serum oestradiol levels ranging 30-1335 pg/ml, a direct relationship was observed between serum oestradiol levels and whole blood serotonin levels (P < 0.001). It was concluded that whole blood serotonin concentration is reduced during menopause by suppression of ovarian function but may also be an effect of ageing.

journal_name

Maturitas

journal_title

Maturitas

authors

Gonzales GF,Carrillo C

doi

10.1016/0378-5122(93)90120-7

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

23-9

issue

1

eissn

0378-5122

issn

1873-4111

pii

0378-5122(93)90120-7

journal_volume

17

pub_type

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