Abstract:
:Most therapy for osteoporosis has been aimed at decreasing bone resorption and is capable of preventing further bone loss. Recently, anabolic steroids have been claimed to cause increased bone mass in osteoporosis, but the mechanism for this effect is not understood. In this study calcium, and calcium with calcitriol, caused a slowing of forearm bone mineral loss. Calcium and ovarian hormones, with or without calcitriol, caused a small non-significant rise in forearm mineral density, and nandrolone decanoate 50 mg intramuscularly, every 2 or 3 weeks caused a significant rise in forearm mineral density (+15.9 +/- 2.4 mg/ml/yr and +13.7 +/- 3.4 mg/ml/yr, respectively). The 3-weekly regime caused few side effects and is considered the optimal dose. The striking rise in bone density in patients in whom bone resorption was controlled before therapy, suggests that anabolic steroids can increase the bone formation rate.
journal_name
Maturitasjournal_title
Maturitasauthors
Need AG,Chatterton BE,Walker CJ,Steurer TA,Horowitz M,Nordin BEdoi
10.1016/0378-5122(86)90035-6subject
Has Abstractpub_date
1986-12-01 00:00:00pages
275-80issue
4eissn
0378-5122issn
1873-4111pii
0378-5122(86)90035-6journal_volume
8pub_type
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