Comparison of calcium, calcitriol, ovarian hormones and nandrolone in the treatment of osteoporosis.

Abstract:

:Most therapy for osteoporosis has been aimed at decreasing bone resorption and is capable of preventing further bone loss. Recently, anabolic steroids have been claimed to cause increased bone mass in osteoporosis, but the mechanism for this effect is not understood. In this study calcium, and calcium with calcitriol, caused a slowing of forearm bone mineral loss. Calcium and ovarian hormones, with or without calcitriol, caused a small non-significant rise in forearm mineral density, and nandrolone decanoate 50 mg intramuscularly, every 2 or 3 weeks caused a significant rise in forearm mineral density (+15.9 +/- 2.4 mg/ml/yr and +13.7 +/- 3.4 mg/ml/yr, respectively). The 3-weekly regime caused few side effects and is considered the optimal dose. The striking rise in bone density in patients in whom bone resorption was controlled before therapy, suggests that anabolic steroids can increase the bone formation rate.

journal_name

Maturitas

journal_title

Maturitas

authors

Need AG,Chatterton BE,Walker CJ,Steurer TA,Horowitz M,Nordin BE

doi

10.1016/0378-5122(86)90035-6

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

275-80

issue

4

eissn

0378-5122

issn

1873-4111

pii

0378-5122(86)90035-6

journal_volume

8

pub_type

杂志文章
  • Assessing predictors of sexual function in mid-aged sexually active women.

    abstract:OBJECTIVE:To assess predictors of sexual function in mid-aged women. METHODS:We analyzed data of 262 healthy sexually active women (40-59 years) who filled out the Female Sexual Functioning Index (FSFI), the Menopause Rating Scale (MRS) and a general questionnaire containing female/partner data. Correlations between t...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2010.12.004

    authors: Chedraui P,Pérez-López FR,Mezones-Holguin E,San Miguel G,Avila C,Collaborative Group for Research of the Climacteric in Latin America (REDLINC).

    更新日期:2011-04-01 00:00:00

  • Long-term effects of percutaneous estradiol on bone loss and bone metabolism in postmenopausal hysterectomized women.

    abstract:OBJECTIVE:To determine whether percutaneous estradiol (pE2) (1.5 mg/day) is able to counteract the postmenopausal bone loss in postmenopausal hysterectomized women, in a double-blind study versus oral estriol (E3) (2 mg/day). METHODS:The bone mineral density of the lumbar spine (LS) and of the proximal femur (PF) was ...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(97)00081-9

    authors: Devogelaer JP,Lecart C,Dupret P,De Nayer P,Nagant De Deuxchaisnes C

    更新日期:1998-01-12 00:00:00

  • The effects of hormone replacement therapy on plasma lipids in type II diabetes.

    abstract:OBJECTIVES:The effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women with non-insulin dependent diabetes mellitus (type II diabetes) is uncertain. METHODS:The effects of estrogen replacement therapy (ERT, conjugated equine estrogen0.625mg orally daily), combined estrogen and con...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(99)00112-7

    authors: Manwaring P,Morfis L,Diamond T,Howes LG

    更新日期:2000-03-31 00:00:00

  • Clinical evaluation, dose-finding and acceptability of AERODIOL, the pulsed estrogen therapy for treatment of climacteric symptoms.

    abstract::S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptab...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/s0378-5122(00)00175-4

    authors: Pelissier C,de Kervasdoue A,Chuong VT,Maugis EL,de Mouillac F,Breil MH,Moniot G,Zeitoun-Lepvrier G,Robin M,Rime B

    更新日期:2001-01-31 00:00:00

  • Ultra low-dose hormone replacement therapy and bone protection in postmenopausal women.

    abstract:OBJECTIVES:The aim of the present study was to evaluate the effects of low doses of hormone replacement therapy (HRT) in normal young postmenopausal women. METHODS:In an open trial healthy, non-obese postmenopausal women received for 2 years a low-dose continuous combined HRT (LD-HRT) containing 1mg estradiol+0.5 mg n...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2007.10.007

    authors: Gambacciani M,Cappagli B,Ciaponi M,Pepe A,Vacca F,Genazzani AR

    更新日期:2008-01-20 00:00:00

  • Bone metabolism regulators and arterial stiffness in postmenopausal women.

    abstract:BACKGROUND:Osteoprotegerin (OPG), osteopontin (OPN) and matrix Gla protein (MGP) are markers of bone metabolism but they are also involved in vascular calcification. However, their precise role is not completely understood. Arterial stiffness is considered an independent predictor of cardiovascular events and it may be...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.07.001

    authors: Albu A,Fodor D,Bondor C,Crăciun AM

    更新日期:2013-10-01 00:00:00

  • Risk factors for clinically diagnosed uterine fibroids in women around menopause.

    abstract:OBJECTIVE:We analysed the risk factors for clinically diagnosed uterine fibroids in women attending menopause clinics in Italy. METHODS:Between 1997 and 2003 we conducted a large cross-sectional study on the characteristics of women around menopause attending a network of first-level outpatient menopause clinics in It...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2006.01.013

    authors: Parazzini F

    更新日期:2006-09-20 00:00:00

  • Climacteric symptoms in a postmenopausal Czech population.

    abstract:OBJECTIVES:To assess the prevalence of climacteric symptoms and the use of hormone replacement therapy in a former eastern European country. All 55-, 57-, 59- and 61-year-old women in Kladno in the Czech Republic were asked to participate in the study. METHOD:In 1993, 1505 women in Kladno of the Czech Republic were se...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(95)00965-5

    authors: Nedstrand E,Pertl J,Hammar M

    更新日期:1996-02-01 00:00:00

  • Andropause and quality of life: findings from patient focus groups and clinical experts.

    abstract:OBJECTIVES:To develop a condition-specific quality of life (QoL) questionnaire to assess the symptoms of the decline in testosterone that occurs as men age, otherwise known as the andropause. METHODS:Two focus groups of patients with low testosterone levels and an expert panel of physicians in the treatment of male te...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(02)00274-8

    authors: Novák A,Brod M,Elbers J

    更新日期:2002-12-10 00:00:00

  • Monitoring of oestrogen replacement therapy by vaginosonography of the endometrium.

    abstract::To prevent hyperplasia and carcinoma of the endometrium during oestrogen replacement therapy (ORT), the addition of progestogens once a month is considered mandatory. However, there is no sound scientific basis for this assumption. As the addition of progestogens has several disadvantages, it is important to minimize ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(92)90059-d

    authors: Meuwissen JH,van Langen H,Moret E,Navarro-Morquecho I

    更新日期:1992-08-01 00:00:00

  • Uterine myoma in postmenopause: a comparison between two therapeutic schedules of HRT.

    abstract:OBJECTIVES:It is still controversial whether hormone replacement therapy (HRT) can affect the onset of uterine myomas or their growth in postmenopause. It is likely that some therapeutic schedules can influence the myometrial growth differently, due to a more potent stimulation of the uterine receptors. The aim of the ...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(00)00159-6

    authors: Polatti F,Viazzo F,Colleoni R,Nappi RE

    更新日期:2000-11-30 00:00:00

  • Menopausal hormone therapy use in relation to breast cancer incidence in 11 European countries.

    abstract:INTRODUCTION:The use of menopausal hormone therapy (MHT) has decreased in many countries in the past 10 years. This is a consequence of the initial publication of the results of the Women's Health Initiative (WHI) randomized trial of estrogen plus progestin. In various countries, further studies then analyzed the incid...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.11.010

    authors: Antoine C,Ameye L,Paesmans M,de Azambuja E,Rozenberg S

    更新日期:2016-02-01 00:00:00

  • Comparative effect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women.

    abstract:BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic ac...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0378-5122(95)00983-3

    authors: Piérard GE,Henry F,Piérard-Franchimont C

    更新日期:1996-04-01 00:00:00

  • Trajectories of the healthy ageing phenotype among middle-aged and older Britons, 2004-2013.

    abstract:OBJECTIVES:Since the ageing population demands a response to ensure older people remain healthy and active, we studied the dynamics of a recently proposed healthy ageing phenotype. We drew the phenotype's trajectories and tested whether their levels and rates of change are influenced by health behaviours, comorbidities...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2016.03.002

    authors: Tampubolon G

    更新日期:2016-06-01 00:00:00

  • Blood serotonin levels in postmenopausal women: effects of age and serum oestradiol levels.

    abstract::This study investigated the effect of ageing and reduction in ovarian function on whole blood serotonin levels and the effect of the oestrogen replacement in postmenopausal women on blood serotonin levels. Amenorrheic, natural postmenopausal and ovariectomised women had lower blood serotonin levels than regularly mens...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(93)90120-7

    authors: Gonzales GF,Carrillo C

    更新日期:1993-07-01 00:00:00

  • Personal use of hormone therapy by postmenopausal women doctors and male doctors' wives in Italy after the publication of WHI trial.

    abstract:OBJECTIVE:To describe the prevalence of hormone replacement therapy (HT) use by postmenopausal women doctors and doctors' wives in Italy and to explore the relationship between their personal characteristics and HT use. DESIGN:A total of 500 women doctors and 500 men doctors answering on behalf of their female partner...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2005.10.008

    authors: Biglia N,Ujcic E,Kubatzki F,Sgandurra P,Robba C,Ponzone R,Sismondi P

    更新日期:2006-05-20 00:00:00

  • The climacteric among South-American women, who immigrated to Sweden and age-matched Swedish women.

    abstract::Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(94)00855-2

    authors: Nedstrand E,Ekseth U,Lindgren R,Hammar M

    更新日期:1995-01-01 00:00:00

  • Cardiovascular disease prevention in women: Impact of dietary interventions.

    abstract::In Western countries, cardiovascular disease is the leading cause of death in women. Prevalence of risk factors and clinical presentation are different in men and women and it is important to take these differences into account in both prevention and treatment. A healthy diet can substantially reduce cardiovascular ri...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2009.02.003

    authors: Hoekstra T,Beulens JW,van der Schouw YT

    更新日期:2009-05-20 00:00:00

  • Classical and newly recognised non-contraceptive benefits of combined hormonal contraceptive use in women over 40.

    abstract::Although age is the most crucial predictor of a woman's reproductive capacity, it is assumed that there is still a risk of pregnancy in menopause transition, as occasional spontaneous ovulation is possible. Moreover, age alone is not sufficient to contraindicate the use of any contraceptive method, whether hormonal or...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2014.02.017

    authors: Mendoza N,Sanchez-Borrego R

    更新日期:2014-05-01 00:00:00

  • The impact of attitudes towards the menopause on women's symptom experience: a systematic review.

    abstract:OBJECTIVES:There is an assumption in menopause research that attitudes to menopause are influenced by a range of cultural, social and psychological variables, which may in turn affect menopausal experience and symptom reporting. However, many studies draw conclusions about this relationship without explicitly examining...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2009.10.016

    authors: Ayers B,Forshaw M,Hunter MS

    更新日期:2010-01-01 00:00:00

  • Physical activity and mammographic parenchymal patterns among Greek postmenopausal women.

    abstract:OBJECTIVE:To examine whether physical activity during the last five years is related to later breast mammographic density in postmenopausal Greek women. METHODS:We designed a cross-sectional study in 724 women, of ages 45-67 years. An interview-administered questionnaire was used to obtain information on duration and ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2011.02.003

    authors: Marmara EA,Papacharalambous XN,Kouloulias VE,Maridaki DM,Baltopoulos JP

    更新日期:2011-05-01 00:00:00

  • Tibolone: a review.

    abstract::Tibolone appears to be at least as efficacious as other forms of hormonal replacement therapy (HRT) on climacteric symptoms. It does not cause withdrawal bleeding when used in women with at least 1 year of amenorrhea. It is, therefore, not indicated in perimenopause because it may cause irregular bleeding. The androge...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/s0378-5122(98)00059-0

    authors: Albertazzi P,Di Micco R,Zanardi E

    更新日期:1998-11-16 00:00:00

  • Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemia.

    abstract:OBJECTIVE:The physiological role of parathormone (PTH) in the maintenance of bone mass in humans has not been fully defined. The main objective of the present study was to evaluate basal and EDTA-stimulated PTH levels in young women (Group Y=30.9 years, N=7) and in women in late menopause (Group M=64.7 years, N=7) and ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2007.10.002

    authors: Pereira LC,Pereira FA,Sá MF,Foss MC,de Paula FJ

    更新日期:2008-01-20 00:00:00

  • Coronary heart disease in menopausal women: implications of primary and secondary prevention trials of hormones.

    abstract::In direct contrast to the observational studies, both primary and secondary prevention trials of female reproductive hormones have found no benefit for coronary heart disease (CHD). Basic science studies have elucidated several mechanisms by which estrogen may improve coronary arterial physiology and prevent pathology...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2005.02.015

    authors: Rossouw JE

    更新日期:2005-05-16 00:00:00

  • Moderate-severely bothersome vasomotor symptoms are associated with lowered psychological general wellbeing in women at midlife.

    abstract:OBJECTIVES:The extent to which menopause influences wellbeing is unclear. We investigated the association between moderate-severely bothersome vasomotor symptoms (VMS) and psychological general wellbeing in women, aged 40-65 years, taking into account socio-demographic and lifestyle factors. STUDY DESIGN/MAIN OUTCOME ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.06.004

    authors: Gartoulla P,Bell RJ,Worsley R,Davis SR

    更新日期:2015-08-01 00:00:00

  • EMAS position statement: The management of postmenopausal women with vertebral osteoporotic fracture.

    abstract:INTRODUCTION:Osteoporotic vertebral fractures are associated with significant morbidity, excess mortality as well as health and social service expenditure. Additionally, women with a prevalent osteoporotic vertebral fracture have a high risk of experiencing a further one within one year. It is therefore important for t...

    journal_title:Maturitas

    pub_type: 杂志文章,实务指引,评审

    doi:10.1016/j.maturitas.2014.03.002

    authors: Triantafyllopoulos IK,Lambropoulou-Adamidou K,Nacopoulos CC,Papaioannou NA,Ceausu I,Depypere H,Erel CT,Pérez-López FR,Schenck-Gustafsson K,van der Schouw YT,Simoncini T,Tremollieres F,Rees M,Lambrinoudaki I,European Menopause

    更新日期:2014-06-01 00:00:00

  • The role of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women.

    abstract::At least 16 million women over the age of 50 currently experience low sexual desire, with approximately 4 million women exhibiting hypoactive sexual desire disorder (HSDD). Although early research established that testosterone therapy improves sexual desire in postmenopausal women, safer and more efficacious administr...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2009.04.008

    authors: Krapf JM,Simon JA

    更新日期:2009-07-20 00:00:00

  • Bone metabolism during the perimenopausal transition: a prospective study.

    abstract:OBJECTIVE:Changes in biochemical markers of bone formation and resorption were followed over the course of 1 year in premenopausal, perimenopausal and early postmenopausal women. METHODS:Sixty-four subjects were analyzed, grouped according to their menstrual pattern, menopausal complaints and endocrinological paramete...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(01)00248-1

    authors: Seifert-Klauss V,Mueller JE,Luppa P,Probst R,Wilker J,Höss C,Treumann T,Kastner C,Ulm K

    更新日期:2002-01-30 00:00:00

  • Impact of seafood and fruit consumption on bone mineral density.

    abstract:OBJECTIVES:Over the past decade, dietary choices and nutrition have proven to be major modulators of bone mineral density (BMD) in men and women. We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population. METHODS:BMDs were measured...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2006.05.001

    authors: Zalloua PA,Hsu YH,Terwedow H,Zang T,Wu D,Tang G,Li Z,Hong X,Azar ST,Wang B,Bouxsein ML,Brain J,Cummings SR,Rosen CJ,Xu X

    更新日期:2007-01-20 00:00:00

  • Determinants of future cardiovascular health in women with a history of preeclampsia.

    abstract::Women who develop preeclampsia have an increased risk of cardiovascular disease (CVD) later in life. However, current guidelines on cardiovascular risk assessment and prevention are unclear on how and when to screen these women postpartum, and about the role of a positive history of preeclampsia in later-life CVD risk...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2015.07.004

    authors: Zoet GA,Koster MP,Velthuis BK,de Groot CJ,Maas AH,Fauser BC,Franx A,van Rijn BB

    更新日期:2015-10-01 00:00:00