Abstract：
OBJECTIVES:Since the ageing population demands a response to ensure older people remain healthy and active, we studied the dynamics of a recently proposed healthy ageing phenotype. We drew the phenotype's trajectories and tested whether their levels and rates of change are influenced by health behaviours, comorbidities and socioeconomic positions earlier in the life course. DESIGN AND OUTCOMES:The English Longitudinal Ageing Study, a prospective, nationally representative sample of people aged ≥50 years, measured a set of eight biomarkers which make up the outcome of the healthy ageing phenotype three times over nearly a decade (N2004=5009, N2008=5301, N2013=4455). A cluster of health behaviours, comorbidities and socioeconomic positions were also measured repeatedly. We assessed the phenotype's distribution non-parametrically, then fitted linear mixed models to phenotypic change and further examined time interactions with gender and socioeconomic position. We ran additional analyses to test robustness. RESULTS:Women had a wider distribution of the healthy ageing phenotype than men had. The phenotype declined annually by -0.242 (95% confidence interval [CI]: -0.352, -0.131). However, there was considerable heterogeneity in the levels and rates of phenotypic change. Women started at higher levels, then declined more steeply by -0.293 (CI: -0.403, -0.183) annually, leading to crossover in the trajectories. Smoking and physical activity assessed on the Allied Dunbar scale were strongly associated with the trajectories. CONCLUSION:Though marked by secular decline, the trajectories of the healthy ageing phenotype showed distinct socioeconomic gradients. The trajectories were also susceptible to variations in health behaviours, strengthening the case for serial interventions to attain healthy and active ageing.
journal_name
Maturitasjournal_title
Maturitasauthors
Tampubolon Gdoi
10.1016/j.maturitas.2016.03.002subject
Has Abstractpub_date
2016-06-01 00:00:00pages
9-15eissn
0378-5122issn
1873-4111pii
S0378-5122(16)30033-0journal_volume
88pub_type
杂志文章相关文献
MATURITAS文献大全abstract：:By establishing a statistical profile of the average sexual behaviour of women during the climacteric period, an attempt was made to determine what influence the climacteric had on female sexual activity. With the advancement of age, the sexual activity of women tends to decline. The menopause itself tends to further ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(82)90016-0
更新日期：1982-04-01 00:00:00
abstract：:An open prospective multicentric trial has been conducted over 6 months in 241 postmenopausal volunteers. One-hundred forty-one women had an intact uterus. All patients received a fixed peroral combination of conjugated estrogens CE (1.25 mg per day from day 1 to day 21) and medrogestone (5 mg per day from day 12 to d...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/0378-5122(93)90055-m
更新日期：1993-03-01 00:00:00
abstract：OBJECTIVES:The extent to which menopause influences wellbeing is unclear. We investigated the association between moderate-severely bothersome vasomotor symptoms (VMS) and psychological general wellbeing in women, aged 40-65 years, taking into account socio-demographic and lifestyle factors. STUDY DESIGN/MAIN OUTCOME ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.06.004
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVES:In one of the earlier hypotheses of the etiology of breast cancer (Korenman's 'oestrogen window' hypothesis (1981)), it was assumed that women with a later age at menopause have a longer period with irregular cycles preceding menopause than women with an early menopause. This assumption was tested in a prosp...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(98)00013-9
更新日期：1998-06-03 00:00:00
abstract：OBJECTIVE:To assess the risk of onset of menopausal symptoms at different periods surrounding menopause, and variations in this risk according to age at menopause and type of menopause. METHODS:We analyzed the 27,897 women participating in the French E3N cohort study who reached menopause during a 10-year follow-up pe...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2007.09.012
更新日期：2007-12-20 00:00:00
abstract：OBJECTIVES:Despite their public health importance, little is known about associations between modifiable lifestyles, quality of life (QOL), and psychiatric symptoms in men. We investigated relationships between QOL, obesity, mobility and lifestyle in Australian men, including whether associations were mediated by anxie...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2017.06.024
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:To develop a condition-specific quality of life questionnaire for the menopause with documented psychometric properties, based on women's experience. METHODS: SUBJECTS:Women 2-7 years post-menopause with a uterus and not currently on hormone replacement therapy. Questionnaire development: A list of 106 meno...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(96)82006-8
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVES:Pilot study to compare the effects of a continuous combined hormone replacement therapy (HRT) regimen with an interrupted progestogen regimen administered transdermally, upon the endometrium of postmenopausal women, the incidence of amenorrhoea and relief of menopausal symptoms. METHODS:Fifty-nine postmenop...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2005.01.013
更新日期：2006-01-10 00:00:00
abstract：:Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(94)00855-2
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of hormone therapy (HT) administered to postmenopausal women on pulmonary function tests (PFT). METHODS:Eighty-two postmenopausal women who were having natural or surgically initiated menopause and had no risk factor that could affect the respiratory system were included into this ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.maturitas.2004.01.009
更新日期：2004-11-15 00:00:00
abstract：OBJECTIVES:Studies focusing on lifestyle and health factors and stress urinary incontinence (SUI) are scarce in Japan. The aim of this study is to examine the association of lifestyle and health factors in SUI. METHODS:Study subjects were retrieved from Japanese women participating in a health checkup program provided...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2010.04.002
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVES:Once weekly dosing of alendronate has been shown to provide equivalent efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women. Whether patients will prefer weekly dosing to daily dosing for a chronic condition such as osteoporosis has not been studied. The aim of this internation...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.maturitas.2003.12.012
更新日期：2004-07-15 00:00:00
abstract：OBJECTIVES:To examine the effect of Cimicifuga racemosa (CR BNO 1055) on hot flushes caused by tamoxifen adjuvant therapy in young premenopausal breast cancer survivors. This treatment presents an off-label use of CR BNO 1055. METHODS:Between May 1999 and December 2001, we accrued 136 breast cancer survivors aged 35-5...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(02)00349-3
更新日期：2003-03-14 00:00:00
abstract：OBJECTIVES:To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement. METHODS:A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omni...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00124-9
更新日期：2000-06-30 00:00:00
abstract：OBJECTIVE:To compare the influence on lipid metabolism of two discontinuous, sequentially combined hormone replacement therapy (HRT) regimens. STUDY DESIGN:In an open, randomized study in 60 women, a full lipid profile including Lp(a) and liver function tests were assessed in a fasting state at the end of treatment cy...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00920-g
更新日期：1995-09-01 00:00:00
abstract：:Five men and 8 women, 60-69 yr of age, and 4 men and 5 women, 17-37 yr of age, volunteered for this exploration of possible age-related changes in circadian-rhythm (CR) characteristics of radioimmunoassayable plasma renin (PRA) and aldosterone (PA). Blood was drawn at 06.00, 08.00, 12.00, 18.00, 20.00 and 24.00 from r...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(81)90009-8
更新日期：1981-08-01 00:00:00
abstract：:Continuous (Kliogest) and sequential (Trisequens) oestrogen-progestogen treatment were compared in a randomized, parallel, group study in women suffering from climacteric symptoms. The subjects were treated with Trisequens for 4 mth prior to randomized assignment to 1 of 2 treatment groups, and with either Trisequens ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(89)90122-9
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:To correlate circulating hormone levels with the clinical and biological features of the tumors in menopausal breast cancer patients. DESIGN:Circulating hormone levels were measured in 161 previously untreated menopausal breast cancer patients within 72 h of their planned surgery. The obtained hormone levels...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2009.07.001
更新日期：2009-09-20 00:00:00
abstract：:It is hypothesized that chronic systemic inflammation contributes to the age-related decline in cardiovascular function. The aim of the present study was to combine an assessment of the relationship between the serum level of C-reactive protein (CRP) and systolic and diastolic blood pressure in 108 elderly women (65 a...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.04.016
更新日期：2016-07-01 00:00:00
abstract：:Worldwide, the number of menopausal women is increasing. They present with complex medical issues that lie beyond the traditional scope of gynaecologists and general practitioners (GPs). The European Menopause and Andropause Society (EMAS) therefore provides a holistic model of care for healthy menopause (HM). The HM ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.06.018
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Previously, the REDLINC VI study showed that the main reason for the low use of menopausal hormone therapy (MHT) was its low rate of prescription by doctors. OBJECTIVE:To determine the use of MHT and perceived related risks among gynecologists. METHODS:A self-administered and anonymous questionnaire was de...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/j.maturitas.2016.02.015
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the expression of oestrogen regulated genes in premenopausal and postmenopausal normal and malignant endometrial specimens. The molecular mechanisms and the role of these genes in endometrial carcinogenesis are poorly understood. METHODS:Normal and malignant endometrial ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.07.009
更新日期：2005-06-16 00:00:00
abstract：:The increasing prevalence of diabetes especially type 2 diabetes worldwide is indisputable. Diabetics suffer increased morbidity and mortality, compared to their non-diabetic counterparts, not only because of vascular complications, but also because of an increased fracture incidence. Both types 1 and 2 diabetes and s...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2013.04.004
更新日期：2013-11-01 00:00:00
abstract：:The effect of estradiol valerate (Progynova, 2 mg daily) on the renin--aldosterone system was studied in nine women after bilateral oophorectomy. Plasma renin activity (PRA) and the daily urinary excretion of aldosterone (dU-Ald) were determined 4 mth after the operation -- during which no estrogen was given -- and af...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(80)90041-9
更新日期：1980-07-01 00:00:00
abstract：:Dementia is a major source of disability worldwide and there are currently no available disease-modifying treatments. Hearing loss may be associated with increased risk of dementia in later life and therefore could be a modifiable risk factor, given the availability of efficacious interventions. We investigated the as...
journal_title：Maturitas
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.maturitas.2018.03.004
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To determine whether individually tailored acupuncture is an effective treatment option for reducing postmenopausal hot flashes and improving quality of life. METHODS:In a randomized, placebo-controlled pilot study, 29 postmenopausal participants averaging at least seven moderate to severe hot flashes per 24...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2006.11.001
更新日期：2007-04-20 00:00:00
abstract：:To prevent hyperplasia and carcinoma of the endometrium during oestrogen replacement therapy (ORT), the addition of progestogens once a month is considered mandatory. However, there is no sound scientific basis for this assumption. As the addition of progestogens has several disadvantages, it is important to minimize ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(92)90059-d
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVES:To evaluate the efficacy of Vitamin D for relieving vaginal atrophy. METHODS:In our cross-sectional study, 60 eligible women were consecutively identified among patients who were followed in physical medicine and rehabilitation's outpatient clinic, during the period March June 2001. The sample consisted of ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.02.008
更新日期：2004-12-10 00:00:00
abstract：AIM:The aim was to investigate bone mineral density (BMD) in breast cancer patients with positive estrogen receptor (ER) tumor status. METHODS:The participants were 110 postmenopausal breast cancer patients with positive estrogen receptor (ER+) tumor status. Two hundred and sixty-one age-matched, healthy postmenopausa...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.11.012
更新日期：2007-07-20 00:00:00
abstract：OBJECTIVE:To assess the symptomatology of menopause and the use of hormone therapy among women in Spain. METHODS:A survey conducted on a representative sample of 300 women aged 45-55 in Madrid. The instrument included closed- and open-ended questions about demographic and socio-economic information, health and reprodu...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2005.01.011
更新日期：2005-11-01 00:00:00
