Abstract：
OBJECTIVES:In one of the earlier hypotheses of the etiology of breast cancer (Korenman's 'oestrogen window' hypothesis (1981)), it was assumed that women with a later age at menopause have a longer period with irregular cycles preceding menopause than women with an early menopause. This assumption was tested in a prospective study. METHODS:Subjects were 628 women, born between 1932 and 1941, who had participated in a breast cancer screening project in Utrecht, The Netherlands (the DOM-project) in 1982-1985, and who were still menstruating at that time. The women had filled out a questionnaire and a menstrual calendar every 2 years to determine their age at menopause prospectively. The women had not used oral contraceptives or medicines for menopausal complaints and had reached natural menopause by 1992. The median of the mean menstrual cycle length per woman and the median of the standard deviation of the mean menstrual cycle length per woman were plotted against number of years prior to menopause in three categories of age at menopause (44-49; 50-54; 55-59). RESULTS:During the 9 years prior to menopause, women with a late age at menopause have a somewhat higher mean menstrual cycle length than women with a younger age at menopause (P = 0.0008). Cycle length variability in the 9 years prior to menopause is not statistically significantly different between the three categories of age at menopause (P = 0.16). CONCLUSIONS:The assumption that women with a late age at menopause have a longer period with irregular cycles than women with an earlier age at menopause was not corroborated by our results.
journal_name
Maturitasjournal_title
Maturitasauthors
den Tonkelaar I,te Velde ER,Looman CWdoi
10.1016/s0378-5122(98)00013-9subject
Has Abstractpub_date
1998-06-03 00:00:00pages
115-23issue
2eissn
0378-5122issn
1873-4111pii
S0378-5122(98)00013-9journal_volume
29pub_type
杂志文章相关文献
MATURITAS文献大全abstract：:Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/s0378-5122(98)00056-5
更新日期：1998-09-20 00:00:00
abstract：:The secretory endometrial protein PP14 was measured in serum from 49 healthy, early post-menopausal women receiving continuous combined oestradiol valerate/cyproterone acetate (2 mg E2V + 1 mg CPA daily) or placebo over a period of 2 years. In the hormone group, serum PP14 increased from 2.1 micrograms/l to a maximum ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(92)90060-h
更新日期：1992-08-01 00:00:00
abstract：OBJECTIVES:An internet survey was performed to obtain data on the current use in Belgium of hormone replacement therapy and alternative treatments for the alleviation of menopausal symptoms. A supplementary aim was to assess the use of opt-in internet opinion panels (TalkToChange, http://www.talktochange.com, and GMI, ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.04.018
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:To compare clinical characteristics and management of adnexal torsion in postmenopausal patients as compared to premenopausal ones. METHODS:A retrospective 22 year cohort of all cases of surgically verified adnexal torsion in postmenopausal and premenopausal patients, comparing presentation, imaging, surgica...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2015.02.261
更新日期：2015-05-01 00:00:00
abstract：:We audited the files of 114 postmenopausal women who had been treated with subcutaneous Estrapel (50mg oestradiol implants). Of the 92 women who received more than one implant, the median number of days between implants was 223.5 (range 49-875), with an estimated median time to return to baseline of 311days (range 108...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2016.09.008
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVES:To link the Menopause Rating Scale (MRS-II) to the International Classification of Functioning, Disability and Health (ICF) and present a clinical application of an ICF-based tool. STUDY DESIGN:The MRS-II was linked to the corresponding ICF category. The linked items were used to generate an ICF Categorical...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.10.003
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the expression of oestrogen regulated genes in premenopausal and postmenopausal normal and malignant endometrial specimens. The molecular mechanisms and the role of these genes in endometrial carcinogenesis are poorly understood. METHODS:Normal and malignant endometrial ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2004.07.009
更新日期：2005-06-16 00:00:00
abstract：:Gonadotropin levels were determined in 17 postmenopausal women before and after administering a single depot-dose of the GnRH agonist triptorelin. E2 levels of all samples were in the normal (low) postmenopausal range and no differences were found when the patients were grouped according to chronological age, or time ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章
doi：10.1016/0378-5122(94)90100-7
更新日期：1994-11-01 00:00:00
abstract：:Hot flashes are a common complaint among women as they transition through menopause. This article reviews the evidence of lifestyle alterations for the amelioration of hot flashes including obesity, exercise, smoking, relaxation techniques, and acupuncture. Further randomized controlled trials regarding these lifestyl...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.12.006
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:In this study we aimed to pilot test the hypothesis that in women who are severely bothered by their menopausal complaints, improvement of menopausal symptoms is associated with an improvement in self-perceived work ability. STUDY DESIGN:This retrospective cohort study assessed the work ability of first-time...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2018.10.015
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Quality of life decreases after the menopause as it has been assessed by several designed tools. Despite this, few studies have reported correlations between quality of life and the metabolic syndrome and its determinants. OBJECTIVE:Evaluate quality of life and determine factors related to its impairment am...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.05.008
更新日期：2007-01-20 00:00:00
abstract：OBJECTIVES:The study purpose was to evaluate the longitudinal effects, after 3 months and 1-year, of a perimenopausal health education intervention for mid-life women in Taiwan. METHODS:This study was conducted at two hospitals and their neighborhood communities (each included three subgroups, traditional Chinese, gyn...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究
doi：10.1016/j.maturitas.2007.01.013
更新日期：2007-07-20 00:00:00
abstract：OBJECTIVES:To estimate the prevalence of disability and its association with morbidity and other social and health-related factors among Spain's non-institutionalized elderly population. METHODS:Cross-sectional survey, by home-based personal interview, covering a sample of 4000 subjects representative of the non-insti...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2003.10.004
更新日期：2004-08-20 00:00:00
abstract：OBJECTIVE:To study the effects of different types of continuous hormone replacement therapy on carbohydrate metabolism. METHOD:Postmenopausal women were treated with conjugated estrogens, 0.625 mg/medroxyprogesterone acetate, 2.5 or 5 mg (CEE/MPA) or tibolone 2.5 mg daily for 13 28-day cycles. Serum glucose and insuli...
journal_title：Maturitas
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.maturitas.2005.03.003
更新日期：2006-01-10 00:00:00
abstract：:Stroke represents one of the most important menaces to public health. A number of modifiable and non-modifiable risk factors have been identified and studied in detail; among those, obesity, the new world epidemic, seems to be one of the most important in terms of prevention. The discovery of the secretory role of the...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.09.002
更新日期：2011-12-01 00:00:00
abstract：:Cardiovascular disease is the leading determinant of mortality and morbidity in women. Functional foods are attracting interest as potential regulators of the susceptibility to disease. Supported by epidemiological evidence, chocolate has emerged as a possible modulator of cardiovascular risk. Chocolate, or cocoa as t...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.05.011
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study is to determine if the depression in perimenopausal women is symptomatologically different than depression in premenopausal women, and if these depressive women are under more risk for depression when factors like premenstrual dysphoric syndrome, socio-economical status, vasomotor sympt...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2006.02.001
更新日期：2006-09-20 00:00:00
abstract：:As increasing numbers of individuals reach very advanced age, it is important to understand the influence of modifiable lifestyle factors such as diet and nutrition on both the achievement of exceptional longevity as well as the maintenance of optimal functional capacity. This includes determining the most appropriate...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.12.002
更新日期：2012-03-01 00:00:00
abstract：:Perimenopause is an imprecise period in woman over 40 years of age, which comprises the time between the moment that the first changes in the menstrual cycle appear and the year following the definitive cessation of the menses. Besides irregular bleeding, many women also complain of hot flashes and other characteristi...
journal_title：Maturitas
pub_type： 杂志文章,实务指引
doi：10.1016/j.maturitas.2012.12.010
更新日期：2013-03-01 00:00:00
abstract：:The occurrence of uterine bleeding usually associated with hormonal replacement therapy is not acceptable for many women. Our objective was to review data on compliance and bleeding patterns in 70 postmenopausal women on oral replacement with estradiol 2 mg, estriol 1 mg, and norethisterone acetate 1 mg daily administ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(96)01048-1
更新日期：1996-10-01 00:00:00
abstract：:By establishing a statistical profile of the average sexual behaviour of women during the climacteric period, an attempt was made to determine what influence the climacteric had on female sexual activity. With the advancement of age, the sexual activity of women tends to decline. The menopause itself tends to further ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(82)90016-0
更新日期：1982-04-01 00:00:00
abstract：OBJECTIVE:To investigate the potential impact of aromatase inhibitors, given after stopping tamoxifen treatment, on the endometrium of postmenopausal breast cancer patients. METHODS:Review of all available literature of studies on aromatase inhibitor therapy in postmenopausal breast cancer patients previously treated ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2008.03.001
更新日期：2008-04-20 00:00:00
abstract：OBJECTIVE:To determine the changes in levels of urinary NTx at the end of the 6th month of oral and transdermal hormone replacement therapy (HRT) and the effects of additional alendronate therapy for osteoporotic women. METHOD:Of 66 postmenopausal women 23 were treated with oral estradiol+norethisterone acetate (E+P),...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00156-1
更新日期：2002-08-30 00:00:00
abstract：OBJECTIVE:To determine whether percutaneous estradiol (pE2) (1.5 mg/day) is able to counteract the postmenopausal bone loss in postmenopausal hysterectomized women, in a double-blind study versus oral estriol (E3) (2 mg/day). METHODS:The bone mineral density of the lumbar spine (LS) and of the proximal femur (PF) was ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(97)00081-9
更新日期：1998-01-12 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic ac...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(95)00983-3
更新日期：1996-04-01 00:00:00
abstract：:A crossover randomized comparison between two different transdermal oestradiol delivery systems has been performed in post-menopausal women of the Bangkok area. Clinical benefits were identical with the use of either a gel, applied once/day on 800 cm2 of skin and which totally evaporated within 3 min, or a patch appli...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(91)90098-b
更新日期：1991-06-01 00:00:00
abstract：:Burning mouth syndrome associated to vulvodynia (Vulvostomatodynia) is a rare condition and is often difficult to diagnose and treat. Tongue, lips, vestibule and others mucosal sites may be affected by a tiresome burning sensation, especially in menopausal and postmenopausal women. Patients seldom report genital sympt...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2007.05.003
更新日期：2007-09-20 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate endothelium-dependent flow-mediated dilation (FMD) in the brachial artery and the plasma levels of endothelin-1 in postmenopausal women at risk for coronary artery disease before and after treatment with both estradiol and estradiol plus dydrogesterone. METHODS:Sixt...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(02)00184-6
更新日期：2002-10-25 00:00:00
abstract：OBJECTIVE:The present study was undertaken to assess the impact, effectiveness and safety of a monophasic hormone replacement treatment (HRT) for continuous use with regards to the clinical effects, bleeding patterns and lipid profile of menopausal women in four Latin American countries. DESIGN:Three hundred and six p...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.maturitas.2004.05.014
更新日期：2005-03-14 00:00:00
abstract：OBJECTIVE:Early onset of menopause results in the premature exposure to low estrogen levels and is associated with a number of postmenopausal health problems and higher risk of mortality. The aim of this study was to determine genetic and environmental factors associated with age at natural and surgical menopause. MET...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2005.08.005
更新日期：2006-04-20 00:00:00
