Hormone replacement therapy in postmenopausal women with specific risk factors for coronary artery disease.

Abstract:

:Hormone replacement therapy (HRT) in postmenopausal women is associated with a reduction in the risk of developing coronary artery disease (CAD) of about 50%. Women with an elevated risk for CAD appear to benefit most by HRT. The HRT-associated cardiovascular protection may be related to favourable changes in several important cardiovascular risk estimators, such as circulating blood concentrations of cholesterol, lipoprotein(a) (Lp(a)) and homocysteine. This paper reviews the literature presently available on the effects of HRT on cholesterol, Lp(a) and homocysteine concentrations, and special attention will be given to the effects on their elevated concentrations. The effect of HRT in women with hypertension is reviewed as well. From this overview it can be concluded that risk factors such as cholesterol, Lp(a), and homocysteine can be favourably modulated by HRT, and especially, that the strongest reductions can be achieved in those women with the highest concentrations. Although clinical trials still need to demonstrate the impact of lowering concentrations of Lp(a) and homocysteine, HRT appears to be a promising risk reduction strategy in this respect.

journal_name

Maturitas

journal_title

Maturitas

authors

van der Mooren MJ,Mijatovic V,van Baal WM,Stehouwer CD

doi

10.1016/s0378-5122(98)00056-5

subject

Has Abstract

pub_date

1998-09-20 00:00:00

pages

27-36

issue

1

eissn

0378-5122

issn

1873-4111

pii

S0378512298000565

journal_volume

30

pub_type

杂志文章,评审
  • The effect of a soy rich diet on the vaginal epithelium in postmenopause: a randomized double blind trial.

    abstract:BACKGROUND:A traditional asiatic phytoestrogen-rich diet is associated with a lower incidence of estrogen-dependent cancers and clinical consequences of postmenopausal estrogen deficiency. First Wilcox in 1990, showed an increase of the vaginal cell maturation with phytoestrogens on postmenopausal women, but this has n...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(03)00080-x

    authors: Chiechi LM,Putignano G,Guerra V,Schiavelli MP,Cisternino AM,Carriero C

    更新日期:2003-08-20 00:00:00

  • Urogenital ageing: an old problem newly recognized.

    abstract::Urogenital symptoms associated with estrogen loss can occur episodically throughout a woman's life (e.g. during lactation, during treatment with GnRH agonists, etc.) but it is most common and chronic in duration in postmenopausal women. More than 50% of postmenopausal women experience lack of vaginal lubrication and f...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(95)00956-6

    authors: Bachmann G

    更新日期:1995-12-01 00:00:00

  • Neuroendocrine effects of different estradiol-progestin regimens in postmenopausal women.

    abstract:OBJECTIVE:New regimens and routes of administration of hormonal replacement therapy (HRT) in climateric women are becoming available. Since there is no information on the neuroendocrine effects of sequential combined treatment with 17 beta-estradiol and a progestin, the present study evaluated the neuroendocrine, clini...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(97)00073-x

    authors: Stomati M,Bersi C,Rubino S,Palumbo M,Comitini G,Genazzani AD,Santuz M,Petraglia F,Genazzani AR

    更新日期:1997-12-15 00:00:00

  • The climacteric among South-American women, who immigrated to Sweden and age-matched Swedish women.

    abstract::Forty-nine immigrated South-American (SA) and 48 Swedish women, aged 42-67 years, were studied in a comparative semi-structured interview survey, concerning the climacteric and its treatment. The mean age at natural menopause was 47 for the South-American women and 50 for the Swedish women. The prevalence of moderate ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(94)00855-2

    authors: Nedstrand E,Ekseth U,Lindgren R,Hammar M

    更新日期:1995-01-01 00:00:00

  • Can physical activity prevent physical and cognitive decline in postmenopausal women? A systematic review of the literature.

    abstract:BACKGROUND:Participation in regular physical activity is among the most promising and cost effective strategies to reduce physical and cognitive decline and premature death. However, confusion remains about the amount, frequency, and duration of physical activity that is likely to provide maximum benefit as well as the...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2014.06.010

    authors: Anderson D,Seib C,Rasmussen L

    更新日期:2014-09-01 00:00:00

  • Paradoxical effects of hormone replacement therapy on breast tenderness in postmenopausal women.

    abstract::We have studied the effect of HRT on breast tenderness in 61 postmenopausal women randomised to oral or transdermal sequential HRT. An untreated reference group of 29 postmenopausal women was studied concurrently. A questionnaire concerning breast tenderness was administered before and after 10, 12 and 24 weeks of tre...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0378-5122(94)90059-0

    authors: Marsh MS,Whitcroft S,Whitehead MI

    更新日期:1994-08-01 00:00:00

  • Neuropsychiatric aspects of dementia.

    abstract::Dementia affects approximately 6.5% of people over the age of 65. Whilst cognitive impairment is central to the dementia concept, neuropsychiatric symptoms are invariably present at some stage of the illness. Neuropsychiatric symptoms result in a number of negative outcomes for the individual and their caregivers and ...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2014.04.005

    authors: Ford AH

    更新日期:2014-10-01 00:00:00

  • Morphometric evaluation of effects of two sex steroids on mammary gland of female rats.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of two sex hormones on normal mammary gland of female rats. METHODS:Forty 250-day-old female rats, 20 of them with offspring and 20 not, were ovariectomized and, divided into 4 subgroups in order to receive one of the following subcutaneous treatment: est...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2004.09.007

    authors: Pompei LM,Carvalho FM,Ortiz SC,Motta MC,Cruz RJ,Melo NR

    更新日期:2005-08-16 00:00:00

  • Role of progestogens in the prevention of breast cancer.

    abstract::The incidence of breast cancer has continued to decrease each year at Wilford Hall United States Air Force Medical Center with the ever-increasing use of combined progestogen-oestrogen replacement therapy over the past 12 yr. By 1983, the overall incidence of breast cancer had fallen to 53.9:100 000. The lowest rate f...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(86)90023-x

    authors: Gambrell RD Jr

    更新日期:1986-07-01 00:00:00

  • Associations between aspects of pain and cognitive performance and the contribution of depressive symptoms in mid-life women: a cross-sectional analysis.

    abstract::Pain has been associated with cognitive problems in pain patients. This study evaluated the extent to which experiences of pain are associated with cognitive performance in a community sample of mid-life women, and the contribution of depressive symptoms to this association. A cross-sectional analysis was used with da...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2014.10.013

    authors: Tomey K,Greendale GA,Kravitz HM,Bromberger JT,Burns JW,Dugan SA,de Leon CF

    更新日期:2015-01-01 00:00:00

  • Body composition, visceral fat distribution and fat oxidation in postmenopausal women using oral or transdermal oestrogen.

    abstract:OBJECTIVES:The aim of this study was to observe hysterectomized postmenopausal women (without progestogen, which could interfere in the results), using oral-conjugated oestrogen 0.625 mg daily (n=13) or 17beta-estradiol transdermal patches delivering 50 microg daily (n=10) during 12 months, and to evaluate the treatmen...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0378-5122(03)00159-2

    authors: dos Reis CM,de Melo NR,Meirelles ES,Vezozzo DP,Halpern A

    更新日期:2003-09-25 00:00:00

  • The effects of hormone replacement therapy on plasma lipids in type II diabetes.

    abstract:OBJECTIVES:The effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women with non-insulin dependent diabetes mellitus (type II diabetes) is uncertain. METHODS:The effects of estrogen replacement therapy (ERT, conjugated equine estrogen0.625mg orally daily), combined estrogen and con...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(99)00112-7

    authors: Manwaring P,Morfis L,Diamond T,Howes LG

    更新日期:2000-03-31 00:00:00

  • Uterine myoma in postmenopause: a comparison between two therapeutic schedules of HRT.

    abstract:OBJECTIVES:It is still controversial whether hormone replacement therapy (HRT) can affect the onset of uterine myomas or their growth in postmenopause. It is likely that some therapeutic schedules can influence the myometrial growth differently, due to a more potent stimulation of the uterine receptors. The aim of the ...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(00)00159-6

    authors: Polatti F,Viazzo F,Colleoni R,Nappi RE

    更新日期:2000-11-30 00:00:00

  • Physical activity and mammographic parenchymal patterns among Greek postmenopausal women.

    abstract:OBJECTIVE:To examine whether physical activity during the last five years is related to later breast mammographic density in postmenopausal Greek women. METHODS:We designed a cross-sectional study in 724 women, of ages 45-67 years. An interview-administered questionnaire was used to obtain information on duration and ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2011.02.003

    authors: Marmara EA,Papacharalambous XN,Kouloulias VE,Maridaki DM,Baltopoulos JP

    更新日期:2011-05-01 00:00:00

  • The association between fear of falling and motor imagery abilities in older community-dwelling individuals.

    abstract::We investigated the association between fear of falling (FoF) and motor imagery (MI) abilities in older people. Cross-sectional data from 3552 French older adults were used to conduct a multiple linear regression analysis looking at the association between FoF and MI abilities after controlling for several factors (e....

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2018.01.001

    authors: Grenier S,Richard-Devantoy S,Nadeau A,Payette MC,Benyebdri F,Duhaime MB,Gunther B,Beauchet O

    更新日期:2018-04-01 00:00:00

  • Risk-reducing mastectomy in BRCA1/2 mutation carriers: factors influencing uptake and timing.

    abstract:INTRODUCTION:Strategies in case of high risk of breast cancer in BRCA1/2 mutation carriers are either intensive breast cancer screening or risk-reducing mastectomy (RRM). Both options have a high physical and psychosexual impact. The aim of this study is to investigate who chooses when to undergo RRM. METHODS:BRCA1/2 ...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2013.10.017

    authors: van Driel CM,Eltahir Y,de Vries J,Jaspers JP,Oosterwijk JC,Mourits MJ,de Bock GH

    更新日期:2014-02-01 00:00:00

  • Grand-parenting for healthy ageing in women: Fact or fiction?

    abstract::Globally our populations are ageing and with this trend, there is a rise in chronic disease. We know that lifestyle and environment are significant contributors to risk for disease, quality of life and function. Despite this representing an opportunity to improve health and quality of life in ageing, there is a paucit...

    journal_title:Maturitas

    pub_type: 社论

    doi:10.1016/j.maturitas.2016.07.004

    authors: Campbell S,Burn K,Szoeke C

    更新日期:2016-10-01 00:00:00

  • Andropause and quality of life: findings from patient focus groups and clinical experts.

    abstract:OBJECTIVES:To develop a condition-specific quality of life (QoL) questionnaire to assess the symptoms of the decline in testosterone that occurs as men age, otherwise known as the andropause. METHODS:Two focus groups of patients with low testosterone levels and an expert panel of physicians in the treatment of male te...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(02)00274-8

    authors: Novák A,Brod M,Elbers J

    更新日期:2002-12-10 00:00:00

  • Deprescribing in older people.

    abstract::Older people with chronic disease have great potential to benefit from their medications but are also at high risk of harm from their medications. The use of medications is particularly important for symptom control and disease progression in older people. Under-treatment means older people can miss out on the potenti...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2016.06.006

    authors: Page AT,Potter K,Clifford R,Etherton-Beer C

    更新日期:2016-09-01 00:00:00

  • Bone metabolism during the perimenopausal transition: a prospective study.

    abstract:OBJECTIVE:Changes in biochemical markers of bone formation and resorption were followed over the course of 1 year in premenopausal, perimenopausal and early postmenopausal women. METHODS:Sixty-four subjects were analyzed, grouped according to their menstrual pattern, menopausal complaints and endocrinological paramete...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(01)00248-1

    authors: Seifert-Klauss V,Mueller JE,Luppa P,Probst R,Wilker J,Höss C,Treumann T,Kastner C,Ulm K

    更新日期:2002-01-30 00:00:00

  • Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders.

    abstract::Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the lit...

    journal_title:Maturitas

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.maturitas.2019.08.006

    authors: Silvestri R,Aricò I,Bonanni E,Bonsignore M,Caretto M,Caruso D,Di Perri MC,Galletta S,Lecca RM,Lombardi C,Maestri M,Miccoli M,Palagini L,Provini F,Puligheddu M,Savarese M,Spaggiari MC,Simoncini T

    更新日期:2019-11-01 00:00:00

  • Shared decision-making in the context of menopausal health: where do we stand?

    abstract::Most health decisions occur in contexts of scientific uncertainty, the "grey zone" of decision-making and many decisions faced by menopausal women are no exception. These contexts are characterized either by scientific evidence that points to a balance between harms and benefits within or between options, or by the ab...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2009.01.013

    authors: Légaré F,Brouillette MH

    更新日期:2009-07-20 00:00:00

  • Breast cancer molecular subtypes--modern therapeutic concepts for targeted therapy of a heterogeneous entity.

    abstract::Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits fr...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2012.08.006

    authors: Liedtke C,Kiesel L

    更新日期:2012-12-01 00:00:00

  • Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review.

    abstract::The identification of early biochemical predictors of osteoarthritis (OA) has been the focus of much research over the past few years. However, it still is unclear whether current biochemical markers can be used in prognostic risk assessment of OA. The aim of this systematic review is to evaluate the possible prognost...

    journal_title:Maturitas

    pub_type: 杂志文章,评审

    doi:10.1016/j.maturitas.2015.04.004

    authors: Hosnijeh FS,Runhaar J,van Meurs JB,Bierma-Zeinstra SM

    更新日期:2015-09-01 00:00:00

  • EMAS position statement: Managing the menopause in women with a past history of endometriosis.

    abstract:INTRODUCTION:Endometriosis is a common disease in women of reproductive age. The symptoms usually disappear after a natural or a surgical menopause. Estrogen-based hormone therapy is required in women with premature or early menopause until the average age of the natural menopause and should be considered in older wome...

    journal_title:Maturitas

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1016/j.maturitas.2010.04.018

    authors: Moen MH,Rees M,Brincat M,Erel T,Gambacciani M,Lambrinoudaki I,Schenck-Gustafsson K,Tremollieres F,Vujovic S,Rozenberg S,European Menopause and Andropause Society.

    更新日期:2010-09-01 00:00:00

  • Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project.

    abstract:UNLABELLED:Social engagement provides dynamic stimulation for older individuals that influences cognition. Grandparenting is an increasingly popular form of childcare that provides social activity for older adults. OBJECTIVE:To investigate the relationship between grandparenting, as a form of social engagement, and co...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/j.maturitas.2015.03.013

    authors: Burn K,Szoeke C

    更新日期:2015-06-01 00:00:00

  • Climacteric symptoms in a Tanzanian community.

    abstract::Climacteric symptoms were investigated among healthy women living in and around a small town in Tanzania. The incidence of symptoms was high and similar to that recorded in Western societies. Statistically significant associations were observed between some symptoms and the number of years since menopause. More attent...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/0378-5122(91)90197-x

    authors: Moore B,Kombe H

    更新日期:1991-09-01 00:00:00

  • Does apolipoprotein E genotype relate to BMD and bone markers in postmenopausal women?

    abstract:OBJECTIVES:Bone mineral density (BMD) and development of osteoporosis are partly determined by genetic factors. The associations between one of suggested candidate, apolipoprotein E (apo E) genotype to bone mineral density (BMD) and bone biochemical markers was studied in 464 subjects recruited from a population-based ...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(99)00084-5

    authors: Heikkinen AM,Kröger H,Niskanen L,Komulainen MH,Ryynänen M,Parviainen MT,Tuppurainen MT,Honkanen R,Saarikoski S

    更新日期:2000-01-15 00:00:00

  • The effects of a soy rich diet on serum lipids: the Menfis randomized trial.

    abstract:OBJECTIVE:To assess beneficial effects of a soy rich diet on the main biomarkers of cardiovascular health in menopause, compared with the effects of the hormone replacement therapy (HRT). METHODS:187 healthy asymptomatic postmenopausal women, aged 39-60, were recruited and randomized into three groups: a soy rich diet...

    journal_title:Maturitas

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0378-5122(01)00259-6

    authors: Chiechi LM,Secreto G,Vimercati A,Greco P,Venturelli E,Pansini F,Fanelli M,Loizzi P,Selvaggi L

    更新日期:2002-02-26 00:00:00

  • The age and symptomatology of natural menopause among United Arab Emirates women.

    abstract:OBJECTIVES:To determine the median age of natural menopause in United Arab Emirates women, the factors affecting that age and the prevalence of climacteric symptoms amongst those women. METHODS:A population-based survey was conducted on a community sample of United Arab Emirates women who had had natural menopause def...

    journal_title:Maturitas

    pub_type: 杂志文章

    doi:10.1016/s0378-5122(98)00010-3

    authors: Rizk DE,Bener A,Ezimokhai M,Hassan MY,Micallef R

    更新日期:1998-06-17 00:00:00