Abstract：
OBJECTIVE:Changes in biochemical markers of bone formation and resorption were followed over the course of 1 year in premenopausal, perimenopausal and early postmenopausal women. METHODS:Sixty-four subjects were analyzed, grouped according to their menstrual pattern, menopausal complaints and endocrinological parameters to be premenopausal (n=20), perimenopausal (n=24) or early postmenopausal (n=20). The parameters studied at four visits during the 12-month study period were the urinary pyridinium cross-links pyridinoline (PYD) and deoxypyridinoline (DPD), and N-terminal telopeptide (NTX) as bone resorption markers, as well as osteocalcin (OC) and bone-specific alkaline phosphatase (BAP) in serum, representing bone formation. The longitudinal changes over time as well as intergroup differences were analyzed using generalized estimating equations (GEE) in connection with Wald statistics. RESULTS:Over the course of 1 year BAP levels decreased in the late premenopausal group (P<0.05). The perimenopausal group exhibited significant changes of PYD, DPD and OC (P<0.01), NTX levels were higher than in premenopause. Postmenopausal subjects had elevated NTX values, while PYD and DPD levels remained close to the perimenopausal range. Only for OC a time effect was seen during postmenopause. CONCLUSIONS:Changes in bone turnover already begin in late premenopause, when decreased bone formation may precede increased bone resorption. The rise of NTX from late premenopause through early postmenopause indicates diagnostic sensitivity of this parameter to changes in bone metabolism induced by estrogen withdrawal. PYD and DPD do not follow this pattern, but change significantly with time during perimenopause to then remain largely unchanged in early postmenopause.
journal_name
Maturitasjournal_title
Maturitasauthors
Seifert-Klauss V,Mueller JE,Luppa P,Probst R,Wilker J,Höss C,Treumann T,Kastner C,Ulm Kdoi
10.1016/s0378-5122(01)00248-1keywords:
subject
Has Abstractpub_date
2002-01-30 00:00:00pages
23-33issue
1eissn
0378-5122issn
1873-4111pii
S0378512201002481journal_volume
41pub_type
杂志文章相关文献
MATURITAS文献大全abstract：:A crossover randomized comparison between two different transdermal oestradiol delivery systems has been performed in post-menopausal women of the Bangkok area. Clinical benefits were identical with the use of either a gel, applied once/day on 800 cm2 of skin and which totally evaporated within 3 min, or a patch appli...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0378-5122(91)90098-b
更新日期：1991-06-01 00:00:00
abstract：:Thirty-four post-menopausal women with climacteric complaints were given conjugated equine oestrogens (1.25 mg/day) for 21 days followed by 2 days without hormones and then 5 mg medroxyprogesteroneacetate daily for 5 days. The present trial was designed to study effects on vasomotor symptoms, bleeding patterns and end...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(84)90065-3
更新日期：1984-07-01 00:00:00
abstract：OBJECTIVES:To evaluate the effect of estrogen replacement therapy (ERT) on postmenopausal bone loss by multi-site ultrasound measurement. METHODS:A cross-sectional comparison of postmenopausal women, ERT users and non-users. The two study groups were enrolled for the reference database collection for the Sunlight Omni...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00124-9
更新日期：2000-06-30 00:00:00
abstract：:Age-related changes in the concentrations of the main plasma electrolytes and in the urinary excretion of some of these ions have been examined in 436 pre-menopausal and 117 post-menopausal women. The main changes up to the menopause were decreases in the mean plasma potassium, calcium and total protein concentrations...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/0378-5122(82)90055-x
更新日期：1982-12-01 00:00:00
abstract：OBJECTIVES:Frailty and cognitive impairment in late life increase the risk of mortality. Physical frailty is closely associated with cognitive impairment. The aim of the study was to examine the independent and interaction effects of frailty and cognitive impairment in predicting mortality. STUDY DESIGN:A nationally r...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2017.10.006
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:Pilot study to compare the effects of a continuous combined hormone replacement therapy (HRT) regimen with an interrupted progestogen regimen administered transdermally, upon the endometrium of postmenopausal women, the incidence of amenorrhoea and relief of menopausal symptoms. METHODS:Fifty-nine postmenop...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2005.01.013
更新日期：2006-01-10 00:00:00
abstract：OBJECTIVE:To measure climacteric symptoms in a population-based survey as assessed by the Greene Climacteric Scale and to obtain normative data for the total score and subscales (psychological, somatic, vasomotor, and sexual) of the Greene Climacteric Scale. METHODS:A sample representative of the Dutch female populati...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00212-7
更新日期：2001-04-20 00:00:00
abstract：:This is a scoping review of the notions of authenticity and citizenship in the context of understanding dementia. Authenticity suggests being true to yourself. Social citizenship suggests engagement, relationships and rights. The literature which links authenticity to dementia is scanty, albeit the notion suggests num...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2019.04.001
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVES:To design a valid and reliable questionnaire, the Malaysian Osteoporosis Knowledge Tool (MOKT), to assess the knowledge of postmenopausal osteoporotic women in Malaysia, on osteoporosis and its treatment. METHODS:A 40-item instrument was designed and tested in this study. The scores ranged from 1 to 40, whi...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2008.04.006
更新日期：2008-06-20 00:00:00
abstract：OBJECTIVES:We studied the effect of hormonal treatment on skin ageing in menopausal women. METHODS:Twenty-four patients (45-68 years; mean age, 54.9 years) without hormone treatment for at least 6 months were included. Patients were assigned to three therapy groups: 1, oestrogen only (Estraderm TTS 50) (n=6); 2, trans...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(00)00225-5
更新日期：2001-07-25 00:00:00
abstract：OBJECTIVE:Estrogen replacement therapy (ERT) has been reported to affect blood pressure. Since natriuretic peptides have natriuretic and vasodilatory activity and also inhibit the renin-angiotensin-aldosterone system and lower blood pressure, it was hypothesized that the changes in blood pressure effected by ERT might ...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0378-5122(03)00279-2
更新日期：2004-03-15 00:00:00
abstract：:With ageing populations a major challenge is to maintain physical and cognitive function, quality of life and independence. The literature does not only indicate important gender differences in lifestyle behaviours, but also how these behaviours might affect health outcomes. The current review has a male perspective w...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2013.02.011
更新日期：2013-06-01 00:00:00
abstract：:The synthetic progestins used so far for contraception and menopausal hormone therapy are derived either from testosterone (19-nortestosterone derivatives) or from progesterone (17-OH progesterone derivatives and 19-norprogesterone derivatives). Among the 19-nortestosterone derivatives, the estrane group include noret...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2004.01.001
更新日期：2004-04-15 00:00:00
abstract：OBJECTIVES:Estrogens modulate lipid metabolism and the increased risk of atherosclerosis in postmenopausal women is at least partly due to the reduction of estrogen production after menopause. We studied the effect of menopause on the contents of long-chain fatty acids, free cholesterol (FC) and cholesterol ester (CE) ...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(03)00247-0
更新日期：2004-02-20 00:00:00
abstract：OBJECTIVES:To examine the potential of a new matrix system developed for estradiol delivery to cause microbial proliferation under the occluded site or to cause acute phototoxicity reactions. METHODS:Twenty healthy post-menopausal women participated in a microbial proliferation study and 11 in a phototoxicity study. B...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(96)01062-6
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate endothelium-dependent flow-mediated dilation (FMD) in the brachial artery and the plasma levels of endothelin-1 in postmenopausal women at risk for coronary artery disease before and after treatment with both estradiol and estradiol plus dydrogesterone. METHODS:Sixt...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(02)00184-6
更新日期：2002-10-25 00:00:00
abstract：:For over a century it has been well documented that bacteria in the vagina maintain vaginal homeostasis, and that an imbalance or dysbiosis may be associated with poor reproductive and gynecologic health outcomes. Vaginal microbiota are of particular significance to postmenopausal women and may have a profound effect ...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.05.015
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:Many women have turned to complementary and alternative medicines for relief from their perimenopausal symptoms. The prevalence of plant-based medicine use among perimenopausal women highlights the need for investigation into these interventions. The aim of this study was to evaluate the benefit of soy prepa...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/s0378-5122(03)00221-4
更新日期：2004-01-20 00:00:00
abstract：OBJECTIVES:To determine the median age of natural menopause in United Arab Emirates women, the factors affecting that age and the prevalence of climacteric symptoms amongst those women. METHODS:A population-based survey was conducted on a community sample of United Arab Emirates women who had had natural menopause def...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(98)00010-3
更新日期：1998-06-17 00:00:00
abstract：PURPOSE:Traditionally, general practitioners (GPs) are not involved in cancer-related treatment decisions, despite their often long relationship with patients, and their unique position to explore patients' values, especially with older patients. Therefore, we designed a randomised controlled trial to study the effect,...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2016.11.014
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVES:To assess the expression of estrogen receptor (ER) in oral mucosa and salivary glands, buccal mucosal biopsies from ten postmenopausal women (taken before and during the hormone replacement therapy), as well as, single biopsies from 20 healthy 19-year-old women were analyzed for ER expression. Salivary gland...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(00)00138-9
更新日期：2000-08-31 00:00:00
abstract：OBJECTIVE:To investigate the relationship between the timing of withdrawal bleeding on hormone replacement therapy and the state of the endometrium. DESIGN:Double-blind, prospectively randomised dose-ranging study. SETTING:Menopause clinics in the UK and the Netherlands. SUBJECTS:Two hundred and seventy one postmeno...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(99)00101-2
更新日期：2000-02-15 00:00:00
abstract：:Stroke represents one of the most important menaces to public health. A number of modifiable and non-modifiable risk factors have been identified and studied in detail; among those, obesity, the new world epidemic, seems to be one of the most important in terms of prevention. The discovery of the secretory role of the...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2011.09.002
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVES:To establish dose proportionality among four doses of a new estradiol transdermal system (ETS), Estradot, in healthy postmenopausal women and to evaluate the wear and irritation properties of the ETS. METHODS:In an open label, single-dose, randomized, four-period crossover study, healthy postmenopausal wome...
journal_title：Maturitas
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0378-5122(03)00189-0
更新日期：2003-11-20 00:00:00
abstract：OBJECTIVES:To describe the characteristics, metabolic control and health-related quality of life (HRQL) of type 2 diabetes mellitus (T2DM) geriatric patients. STUDY DESIGN:Cross-sectional descriptive study of consecutive patients attended at a geriatric outpatient clinic in a tertiary hospital over three months. Socio...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2011.05.001
更新日期：2011-08-01 00:00:00
abstract：:The extension of life expectancy is a global phenomenon. The growth in the ageing population has created a new health scenario in which there is a higher prevalence of frailty and multimorbidity. The attention received by both conditions derives from their strong association with disability, hospitalization, and death...
journal_title：Maturitas
pub_type： 杂志文章,评审
doi：10.1016/j.maturitas.2016.10.008
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:The goal of this study was to search the effects of two different doses of tibolone on endometrial IGF-1 and IGFBP-1 levels in ovariectomized rats. METHODS:Eighteen adult, female, 80-90-days-old, Wistar rats with an average weight of 250 g underwent bilateral ovariectomy under general anesthesia. After waiti...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00068-3
更新日期：2002-07-25 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effects of different types of hormone replacement therapy (HRT) on mammographic density. MATERIALS AND METHODS:In a prospective 1-year study, 103 postmenopausal women were randomized to receive tibolone 2.5 mg/die, continuous conjugated equine estrogens 0.625 mg/die ...
journal_title：Maturitas
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.maturitas.2005.02.010
更新日期：2006-01-10 00:00:00
abstract：BACKGROUND:Studies assessing physical functioning with the Physical Activity Scale for the Elderly (PASE) should be aware that the instrument may be age and culture insensitive. OBJECTIVES:To asses "classical" PASE scoring in a sample of aged (mean age 74) Mexican origin Latinos in the Southwestern United States and p...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/j.maturitas.2012.05.009
更新日期：2012-08-01 00:00:00
abstract：:In the present study, we report on an additive evaluation of mental well-being in an established program of preventive medicine including general and gynecologic examination, and screening mammography. An easy-to-use questionnaire including 19 questions was completed by 5247 women. Answers were grouped into mental wel...
journal_title：Maturitas
pub_type： 杂志文章
doi：10.1016/s0378-5122(02)00010-5
更新日期：2002-04-15 00:00:00
