Comparative effect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women.

Abstract:

BACKGROUND AND OBJECTIVES:Cutaneous intrinsic ageing has been shown to be improved by hormone replacement therapy (HRT). Photoageing is, however, unresponsive to such treatment. The present double-blind study was undertaken to compare the beneficial effect of a 1-month topical treatment with 0.05% all-trans-retinoic acid or 6% glycolic acid. METHOD:Biomechanical properties were measured on facial skin of HRT-treated menopausal women using both topical products on the hemifaces for 1 month. RESULTS:Skin elasticity proved to be significantly higher at the tretinoin-treated site than at the glycolic acid-treated site. CONCLUSION:Objective non-invasive measurements of the biomechanical properties of facial skin show the superiority of retinoic acid over glycolic acid in improving a deleterious effect of ageing.

journal_name

Maturitas

journal_title

Maturitas

authors

Piérard GE,Henry F,Piérard-Franchimont C

doi

10.1016/0378-5122(95)00983-3

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

273-7

issue

3

eissn

0378-5122

issn

1873-4111

pii

0378512295009833

journal_volume

23

pub_type

临床试验,杂志文章,随机对照试验
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