Abstract:
OBJECTIVES:To examine the association between the principal lifetime occupation and the incidence of Alzheimer's disease (AD) in men and women in a southern European population aged 55 years or more. STUDY DESIGN:A community-dwelling sample of 3883 dementia-free individuals aged 55 years or over was classified according the Spanish National Classification of Occupations (CNO-11) and the International Standard Classification of Occupations (ISCO-08) in a four-wave epidemiological study. Medical and psychiatric histories were collected using standardized instruments, including the Mini-Mental Status Examination (MMSE), the History and Aetiology Schedule (HAS), the Geriatric Mental State-AGECAT, and a risk factor Questionnaire. Cases of AD were diagnosed according to DSM-IV criteria. Cox regression models were performed, stratified by sex. MAIN OUTCOME MEASURES:Cases of AD according to the main occupation and sex. RESULTS:In men, compared with the "white collar" category, the risk of AD in "farmers" was 66% times lower, after controlling for potential confounding factors (HR: 0.34; 95% CI: 0.08-1.33). It did not reach statistical significance but the magnitude was large (Cohen's d = 0.84). In women, "farmers" had almost 50% less risk of AD after controlling for all potential confounding factors (HR: 0.55; 95% CI: 0.17-1.78), compared with homemakers, but with a medium effect size (Cohen's d = 0.46). CONCLUSIONS:Men and women farmers had a lower risk of AD, reinforcing the importance of lifetime occupation in the risk of AD at older ages. These results could suggest some environmental hypotheses.
journal_name
Maturitasjournal_title
Maturitasauthors
Santabárbara J,Gracía-Rebled AC,López-Antón R,Tomás C,Lobo E,Marcos G,Lobo Adoi
10.1016/j.maturitas.2019.05.008subject
Has Abstractpub_date
2019-08-01 00:00:00pages
61-68eissn
0378-5122issn
1873-4111pii
S0378-5122(18)30673-Xjournal_volume
126pub_type
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